| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: Eclipse | - | - | - | $216,646 | 1 | $216,646 | Jul 2 | - | false |
| 2 | Salt | - | - | - | $49,723 | 1 | $49,723 | Aug 13 | Sony Pictures Releasing | false |
| 3 | Clash of the Titans | - | - | - | $49,473 | 1 | $49,473 | Apr 2 | Warner Bros. | false |
| 4 | Inception | - | - | - | $37,578 | 1 | $37,578 | Jul 30 | Warner Bros. | false |
| 5 | Prince of Persia: The Sands of Time | - | - | - | $37,529 | 1 | $37,529 | May 28 | Walt Disney Pictures | false |
| 6 | Avatar | - | - | - | $37,335 | 1 | $59,590 | Dec 18 | Warner Bros. | false |
| 7 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $36,655 | 1 | $36,655 | Nov 26 | Warner Bros. | false |
| 8 | Sherlock Holmes | - | - | - | $32,109 | 1 | $32,109 | Dec 31 | Warner Bros. | false |
| 9 | Takers 2010 Re-release | - | - | - | $30,229 | 1 | $30,229 | Oct 22 | Sony Pictures Releasing | false |
| 10 | The Bounty Hunter | - | - | - | $26,254 | 1 | $26,254 | Apr 16 | Sony Pictures Releasing | false |
| 11 | Date Night | - | - | - | $24,284 | 1 | $24,284 | Apr 9 | - | false |
| 12 | Eat Pray Love | - | - | - | $22,446 | 1 | $22,446 | Oct 1 | Sony Pictures Releasing | false |
| 13 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $21,681 | 1 | $21,681 | Feb 19 | 20th Century Fox International | false |
| 14 | Couples Retreat | - | - | - | $20,932 | 1 | $31,252 | Dec 18 | Universal Pictures International (UPI) | false |
| 15 | Unstoppable | - | - | - | $20,742 | 1 | $20,742 | Nov 19 | - | false |
| 16 | Alice in Wonderland | - | - | - | $20,391 | 1 | $20,391 | Mar 5 | Walt Disney Pictures | false |
| 17 | The Other Guys | - | - | - | $18,255 | 1 | $18,255 | Sep 24 | Sony Pictures Releasing | false |
| 18 | The Sorcerer's Apprentice | - | - | - | $17,797 | 1 | $17,797 | Jul 16 | 20th Century Fox International | false |
| 19 | Faster | - | - | - | $17,706 | 1 | $21,720 | Dec 24 | Sony Pictures Releasing | false |
| 20 | Knight and Day 2010 Re-release | - | - | - | $17,522 | 1 | $17,522 | Jul 23 | Paramount Pictures International | false |
| 21 | How to Train Your Dragon | - | - | - | $17,382 | 1 | $17,382 | Apr 2 | Warner Bros. | false |
| 22 | Step Up 3D | - | - | - | $16,882 | 1 | $16,882 | Sep 3 | Walt Disney Pictures | false |
| 23 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $15,519 | 1 | $15,519 | Aug 13 | Warner Bros. | false |
| 24 | Sex and the City 2 | - | - | - | $15,378 | 1 | $15,378 | May 28 | Warner Bros. | false |
| 25 | The Back-up Plan | - | - | - | $14,332 | 1 | $14,332 | May 14 | Sony Pictures Releasing | false |
| 26 | Grown Ups | - | - | - | $14,073 | 1 | $14,073 | Aug 27 | Sony Pictures Releasing | false |
| 27 | When in Rome | - | - | - | $13,927 | 1 | $13,927 | Jan 29 | - | false |
| 28 | Wall Street: Money Never Sleeps | - | - | - | $13,663 | 1 | $13,663 | Oct 8 | Warner Bros. | false |
| 29 | Shrek Forever After | - | - | - | $13,522 | 1 | $13,522 | Jul 23 | Universal Pictures International (UPI) | false |
| 30 | Despicable Me | - | - | - | $13,242 | 1 | $13,242 | Oct 8 | Universal Pictures International (UPI) | false |
| 31 | Robin Hood | - | - | - | $13,082 | 1 | $13,082 | May 21 | Universal Pictures International (UPI) | false |
| 32 | Toy Story 3 | - | - | - | $12,774 | 1 | $12,774 | Jun 18 | Walt Disney Pictures | false |
| 33 | The Karate Kid | - | - | - | $12,225 | 1 | $12,225 | Sep 10 | Sony Pictures Releasing | false |
| 34 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $12,007 | 1 | $16,019 | Dec 23 | 20th Century Fox International | false |
| 35 | Law Abiding Citizen | - | - | - | $11,528 | 1 | $11,528 | Jan 22 | - | false |
| 36 | Did You Hear About the Morgans? | - | - | - | $11,189 | 1 | $11,189 | Feb 19 | Sony Pictures Releasing | false |
| 37 | It's Complicated | - | - | - | $11,022 | 1 | $11,022 | Mar 5 | Universal Pictures International (UPI) | false |
| 38 | Shutter Island | - | - | - | $11,005 | 1 | $11,005 | Mar 19 | Universal Pictures International (UPI) | false |
| 39 | Tangled | - | - | - | $10,727 | 1 | $10,727 | Dec 3 | Walt Disney Pictures | false |
| 40 | Cop Out | - | - | - | $10,719 | 1 | $10,719 | Mar 26 | 20th Century Fox International | false |
| 41 | My Name Is Khan | - | - | - | $10,136 | 1 | $10,136 | Feb 19 | 20th Century Fox International | false |
| 42 | Tooth Fairy | - | - | - | $10,082 | 1 | $10,082 | Mar 19 | 20th Century Fox International | false |
| 43 | The Wolfman | - | - | - | $9,772 | 1 | $9,772 | Feb 19 | Universal Pictures International (UPI) | false |
| 44 | Our Family Wedding | - | - | - | $9,065 | 1 | $9,065 | Aug 6 | 20th Century Fox International | false |
| 45 | Housefull | - | - | - | $8,965 | 1 | $8,965 | Apr 30 | - | false |
| 46 | Iron Man 2 | - | - | - | $8,290 | 1 | $8,290 | Jun 11 | Universal Pictures International (UPI) | false |
| 47 | The Last Airbender | - | - | - | $8,003 | 1 | $8,003 | Sep 17 | Universal Pictures International (UPI) | false |
| 48 | Due Date | - | - | - | $7,328 | 1 | $12,055 | Dec 10 | Warner Bros. | false |
| 49 | Armored | - | - | - | $7,310 | 1 | $7,310 | Mar 26 | Sony Pictures Releasing | false |
| 50 | Predators | - | - | - | $7,296 | 1 | $7,296 | Aug 13 | 20th Century Fox International | false |
| 51 | The Social Network | - | - | - | $7,082 | 1 | $7,082 | Nov 19 | Sony Pictures Releasing | false |
| 52 | Death at a Funeral | - | - | - | $7,062 | 1 | $7,062 | Jun 4 | Sony Pictures Releasing | false |
| 53 | The Blind Side | - | - | - | $6,945 | 2 | $6,945 | Mar 12 | 20th Century Fox International | false |
| 54 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $6,630 | 1 | $6,630 | Dec 10 | Walt Disney Pictures | false |
| 55 | Green Zone 2010 Re-release | - | - | - | $6,530 | 1 | $6,530 | Jun 11 | Universal Pictures International (UPI) | false |
| 56 | Raajneeti | - | - | - | $6,473 | 1 | $6,473 | Jun 4 | - | false |
| 57 | Tron: Legacy | - | - | - | $5,654 | 1 | $12,111 | Dec 17 | - | false |
| 58 | Kites | - | - | - | $5,545 | 1 | $5,545 | May 21 | - | false |
| 59 | Anjaana Anjaani | - | - | - | $5,423 | 1 | $5,423 | Oct 1 | - | false |
| 60 | Legion | - | - | - | $5,375 | 1 | $5,375 | May 21 | Sony Pictures Releasing | false |
| 61 | Marmaduke | - | - | - | $3,729 | 1 | $3,729 | Jun 11 | 20th Century Fox International | false |
| 62 | The Losers | - | - | - | $3,237 | 1 | $3,237 | Jul 16 | 20th Century Fox International | false |
| 63 | The Princess and the Frog | - | - | - | $3,089 | 1 | $8,196 | Dec 11 | Walt Disney Pictures | false |
| 64 | Brooklyn's Finest 2010 Re-release | - | - | - | $2,735 | 1 | $2,735 | Sep 17 | - | false |
| 65 | Machete | - | - | - | $2,568 | 1 | $2,568 | Nov 5 | Sony Pictures Releasing | false |
| 66 | Old Dogs | - | - | - | $1,922 | 1 | $1,922 | Feb 26 | Walt Disney Pictures | false |
| 67 | I Love You Phillip Morris | - | - | - | $1,620 | 1 | $1,620 | Jul 16 | Universal Pictures International (UPI) | false |
