| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $1,189,886 | 18 | $1,917,323 | Dec 17 | 20th Century Fox International | false |
| 2 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $562,573 | 13 | $576,300 | Jan 28 | 20th Century Fox International | false |
| 3 | Eat Pray Love | - | - | - | $386,410 | 8 | $386,410 | Sep 23 | Sony Pictures Releasing | false |
| 4 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $362,148 | 16 | $416,863 | Nov 18 | Warner Bros. | false |
| 5 | Despicable Me | - | - | - | $357,217 | 18 | $362,636 | Oct 14 | United International Pictures | false |
| 6 | Shrek Forever After | - | - | - | $335,598 | 26 | $358,751 | May 27 | United International Pictures | false |
| 7 | Inception | - | - | - | $309,783 | 10 | $358,652 | Jul 22 | Warner Bros. | false |
| 8 | Robin Hood | - | - | - | $299,583 | 15 | $327,167 | May 13 | United International Pictures | false |
| 9 | How to Train Your Dragon | - | - | - | $298,334 | 14 | $347,028 | Apr 1 | United International Pictures | false |
| 10 | Saw 3D | - | - | - | $292,455 | 11 | $313,423 | Oct 28 | - | false |
| 11 | Sherlock Holmes | - | - | - | $242,984 | 9 | $261,903 | Jan 7 | Warner Bros. | false |
| 12 | Toy Story 3 | - | - | - | $224,940 | 13 | $234,447 | Aug 12 | Walt Disney Pictures | false |
| 13 | The Bounty Hunter | - | - | - | $217,357 | 9 | $217,357 | Apr 1 | Sony Pictures Releasing | false |
| 14 | Step Up 3D | - | - | - | $216,066 | 6 | $227,845 | Sep 23 | - | false |
| 15 | Valentine's Day | - | - | - | $204,801 | 9 | $246,792 | Feb 18 | Warner Bros. | false |
| 16 | Clash of the Titans | - | - | - | $204,423 | 15 | $220,122 | Apr 22 | Warner Bros. | false |
| 17 | Little Fockers | - | - | - | $204,150 | 13 | $518,587 | Dec 23 | United International Pictures | false |
| 18 | Knight and Day 2010 Re-release | - | - | - | $202,606 | 12 | $230,562 | Jul 29 | 20th Century Fox International | false |
| 19 | Grown Ups | - | - | - | $186,483 | 7 | $251,066 | Jul 15 | Sony Pictures Releasing | false |
| 20 | It's Complicated | - | - | - | $185,533 | 8 | $299,517 | Dec 24 | United International Pictures | false |
| 21 | Shutter Island | - | - | - | $182,034 | 5 | $190,246 | Mar 11 | United International Pictures | false |
| 22 | Salt | - | - | - | $181,929 | 10 | $181,929 | Aug 19 | Sony Pictures Releasing | false |
| 23 | Sex and the City 2 | - | - | - | $171,882 | 17 | $206,549 | Jun 3 | Warner Bros. | false |
| 24 | Dinner for Schmucks | - | - | - | $169,770 | 8 | $173,663 | Sep 16 | United International Pictures | false |
| 25 | Alice in Wonderland | - | - | - | $169,622 | 8 | $171,221 | Mar 4 | Walt Disney Pictures | false |
| 26 | Leap Year | - | - | - | $155,506 | 8 | $163,068 | Mar 4 | United International Pictures | false |
| 27 | The Back-up Plan | - | - | - | $151,577 | 7 | $151,577 | May 6 | Sony Pictures Releasing | false |
| 28 | Due Date | - | - | - | $150,883 | 8 | $230,944 | Dec 2 | Warner Bros. | false |
| 29 | The Sorcerer's Apprentice | - | - | - | $142,069 | 10 | $147,564 | Sep 16 | Walt Disney Pictures | false |
| 30 | She's Out of My League | - | - | - | $138,583 | 8 | $145,145 | Apr 15 | United International Pictures | false |
| 31 | Megamind | - | - | - | $138,336 | 18 | $177,852 | Dec 2 | United International Pictures | false |
| 32 | Get Him to the Greek | - | - | - | $134,427 | 9 | $140,899 | Aug 5 | United International Pictures | false |
| 33 | Planet 51 | - | - | - | $126,160 | 10 | $179,710 | Dec 31 | - | false |
| 34 | The Last Airbender | - | - | - | $121,307 | 17 | $179,326 | Aug 5 | United International Pictures | false |
| 35 | Prince of Persia: The Sands of Time | - | - | - | $120,934 | 12 | $129,612 | May 20 | Walt Disney Pictures | false |
| 36 | Marmaduke | - | - | - | $120,078 | 8 | $125,528 | Aug 19 | 20th Century Fox International | false |
| 37 | The Wolfman | - | - | - | $118,849 | 7 | $127,464 | Feb 18 | United International Pictures | false |
| 38 | The Social Network | - | - | - | $118,803 | 7 | $153,204 | Oct 28 | Sony Pictures Releasing | false |
| 39 | Up in the Air | - | - | - | $118,140 | 5 | $125,379 | Jan 14 | United International Pictures | false |
| 40 | Did You Hear About the Morgans? | - | - | - | $117,342 | 8 | $117,342 | Feb 4 | Sony Pictures Releasing | false |
| 41 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $116,856 | 18 | $161,059 | Dec 9 | 20th Century Fox International | false |
| 42 | The Karate Kid | - | - | - | $114,944 | 12 | $120,832 | Sep 2 | Sony Pictures Releasing | false |
| 43 | The Expendables | - | - | - | $114,270 | 6 | $128,090 | Aug 19 | - | false |
| 44 | Iron Man 2 | - | - | - | $111,680 | 6 | $122,290 | Apr 29 | United International Pictures | false |
| 45 | The Princess and the Frog | - | - | - | $111,379 | 9 | $115,260 | Jan 21 | Walt Disney Pictures | false |
| 46 | The Other Guys | - | - | - | $110,987 | 7 | $110,987 | Oct 21 | Sony Pictures Releasing | false |
| 47 | Resident Evil: Afterlife | - | - | - | $90,699 | 17 | $90,699 | Sep 10 | Sony Pictures Releasing | false |
| 48 | Life as We Know It | - | - | - | $89,034 | 7 | $189,457 | Dec 16 | Warner Bros. | false |
| 49 | When in Rome | - | - | - | $88,764 | 6 | $92,940 | Apr 22 | Walt Disney Pictures | false |
| 50 | Going the Distance | - | - | - | $86,828 | 7 | $88,262 | Sep 9 | Warner Bros. | false |
| 51 | The Book of Eli | - | - | - | $84,748 | 6 | $90,552 | Jan 21 | - | false |
| 52 | Easy A | - | - | - | $80,862 | 7 | $80,862 | Nov 11 | Sony Pictures Releasing | false |
| 53 | You Again | - | - | - | $80,668 | 6 | $91,973 | Oct 28 | Walt Disney Pictures | false |
| 54 | Cloudy with a Chance of Meatballs | - | - | - | $73,067 | 13 | $73,067 | Feb 11 | Sony Pictures Releasing | false |
| 55 | The Twilight Saga: Eclipse | - | - | - | $72,605 | 13 | $329,475 | Jul 1 | - | false |
| 56 | Paranormal Activity 2 | - | - | - | $69,242 | 8 | $87,515 | Dec 9 | United International Pictures | false |
| 57 | The Men Who Stare at Goats | - | - | - | $66,499 | 4 | $74,580 | Jan 28 | - | false |
| 58 | The Flight Before Christmas | - | - | - | $64,109 | 8 | $451,221 | Dec 3 | - | false |
| 59 | Tron: Legacy | - | - | - | $61,590 | 14 | $102,880 | Dec 16 | Walt Disney Pictures | false |
| 60 | Devil | - | - | - | $61,549 | 7 | $70,951 | Oct 28 | United International Pictures | false |
| 61 | Remember Me | - | - | - | $61,010 | 6 | $65,975 | Apr 15 | - | false |
| 62 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $58,825 | 11 | $64,045 | Aug 26 | Warner Bros. | false |
| 63 | Green Zone | - | - | - | $55,873 | 6 | $58,433 | Mar 18 | United International Pictures | false |
| 64 | The A-Team | - | - | - | $55,086 | 7 | $58,921 | Aug 12 | 20th Century Fox International | false |
| 65 | Old Dogs | - | - | - | $53,276 | 6 | $157,569 | Dec 10 | Walt Disney Pictures | false |
| 66 | Wall Street: Money Never Sleeps | - | - | - | $49,816 | 4 | $51,037 | Nov 4 | 20th Century Fox International | false |
| 67 | The Switch | - | - | - | $49,540 | 3 | $51,404 | Oct 7 | - | false |
| 68 | Machete | - | - | - | $48,099 | 4 | $49,648 | Sep 2 | - | false |
| 69 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $46,724 | 8 | $47,562 | Mar 11 | 20th Century Fox International | false |
| 70 | Nine | - | - | - | $46,375 | 4 | $48,920 | Mar 4 | - | false |
| 71 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $43,944 | 11 | $46,889 | Sep 30 | Warner Bros. | false |
| 72 | Invictus | - | - | - | $38,318 | 5 | $44,070 | Feb 25 | Warner Bros. | false |
| 73 | The Hurt Locker | - | - | - | $34,123 | 2 | $39,408 | Feb 18 | - | false |
| 74 | The Kings of Mykonos | - | - | - | $30,340 | 3 | $32,023 | Aug 26 | - | false |
| 75 | Triage | - | - | - | $29,558 | 7 | $31,456 | Apr 8 | - | false |
| 76 | Legion | - | - | - | $29,471 | 5 | $29,471 | Feb 25 | Sony Pictures Releasing | false |
| 77 | Edge of Darkness | - | - | - | $25,948 | 4 | $27,536 | Feb 11 | - | false |
| 78 | Charlie St. Cloud | - | - | - | $24,054 | 8 | $26,102 | Sep 9 | United International Pictures | false |
| 79 | Love Happens | - | - | - | $23,885 | 5 | $81,650 | Dec 10 | - | false |
| 80 | Predators | - | - | - | $22,471 | 7 | $63,918 | Jul 8 | 20th Century Fox International | false |
| 81 | The American | - | - | - | $20,778 | 5 | $24,725 | Dec 9 | - | false |
| 82 | Heartbreaker | - | - | - | $19,985 | 4 | $21,679 | Nov 25 | - | false |
| 83 | The Other Man | - | - | - | $19,289 | 6 | $23,191 | Feb 4 | - | false |
| 84 | Chatroom | - | - | - | $19,266 | 6 | $21,019 | Oct 21 | - | false |
| 85 | Paranormal Activity | - | - | - | $19,082 | 6 | $124,623 | Dec 10 | - | false |
| 86 | Daybreakers | - | - | - | $18,937 | 4 | $20,803 | Jan 14 | - | false |
| 87 | Scott Pilgrim vs. the World | - | - | - | $18,586 | 6 | $20,495 | Sep 30 | United International Pictures | false |
| 88 | Killers | - | - | - | $18,490 | 6 | $96,781 | Jun 24 | - | false |
| 89 | The Crazies | - | - | - | $16,867 | 2 | $17,928 | Sep 23 | - | false |
| 90 | Tamara Drewe | - | - | - | $16,860 | 6 | $18,652 | Nov 18 | - | false |
| 91 | Gamer | - | - | - | $15,873 | 6 | $19,952 | Feb 4 | - | false |
| 92 | The Romantics | - | - | - | $15,548 | 3 | $16,453 | Nov 25 | - | false |
| 93 | A Nightmare on Elm Street | - | - | - | $13,407 | 6 | $63,170 | Jun 24 | Warner Bros. | false |
| 94 | Mother and Child | - | - | - | $13,222 | 5 | $18,531 | Aug 26 | United International Pictures | false |
| 95 | RED | - | - | - | $12,257 | 3 | $14,336 | Dec 9 | - | false |
| 96 | Splice 2010 Re-release | - | - | - | $11,307 | 2 | $12,923 | Aug 5 | - | false |
| 97 | The Lovely Bones | - | - | - | $11,058 | 5 | $13,243 | Feb 25 | United International Pictures | false |
| 98 | Capitalism: A Love Story | - | - | - | $10,903 | 1 | $17,906 | Dec 31 | - | false |
| 99 | Coco Chanel & Igor Stravinsky | - | - | - | $10,860 | 1 | $16,790 | Dec 31 | - | false |
| 100 | Letters to Juliet | - | - | - | $10,301 | 5 | $24,811 | Jul 8 | - | false |
| 101 | The Twilight Saga: New Moon | - | - | - | $8,652 | 12 | $386,761 | Nov 26 | - | false |
| 102 | An Education | - | - | - | $8,221 | 2 | $9,492 | Feb 18 | - | false |
| 103 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $7,200 | 1 | $11,381 | Jan 14 | - | false |
| 104 | A Serious Man | - | - | - | $7,006 | 1 | $7,920 | Feb 4 | - | false |
| 105 | 2012 | - | - | - | $5,982 | 15 | $482,522 | Nov 12 | Sony Pictures Releasing | false |
| 106 | Whip It | - | - | - | $4,866 | 4 | $27,217 | Dec 3 | - | false |
| 107 | Everybody's Fine | - | - | - | $4,300 | 2 | $5,156 | Mar 11 | Walt Disney Pictures | false |
| 108 | Sin Nombre | - | - | - | $4,244 | 1 | $9,309 | Jan 14 | - | false |
| 109 | Broken Embraces | - | - | - | $2,223 | 2 | $57,298 | Nov 26 | - | false |
