| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Star Wars: Episode III - Revenge of the Sith | $342,784 | -42.7% | 115 | - | $2,980 | $3,967,062 | 4 | 20th Century Fox International | false | false |
| 2 | 2 | Sin City | $223,367 | -22.2% | 83 | - | $2,691 | $659,246 | 2 | RCV Film Distribution | false | false |
| 3 | 3 | A Lot Like Love | $157,289 | -25.1% | 45 | - | $3,495 | $460,204 | 2 | Buena Vista International | false | false |
| 4 | - | Guess Who | $152,171 | - | 34 | - | $4,475 | $184,470 | 1 | 20th Century Fox International | true | false |
| 5 | 5 | Hostage | $106,559 | -25.4% | 63 | - | $1,691 | $508,009 | 3 | Independent Films | false | false |
| 6 | 4 | Kingdom of Heaven | $105,232 | -28.6% | 91 | -8 | $1,156 | $2,727,148 | 6 | 20th Century Fox International | false | false |
| 7 | 6 | House of Wax | $68,498 | -34.3% | 39 | -1 | $1,756 | $352,497 | 3 | Warner Bros. | false | false |
| 8 | 7 | The Pacifier | $65,929 | -28.3% | 67 | - | $984 | $2,109,186 | 7 | Buena Vista International | false | false |
| 9 | - | Saw | $64,995 | - | 21 | - | $3,095 | $82,239 | 1 | Inspire Pictures | true | false |
| 10 | 8 | The Wedding Date | $36,748 | -33% | 50 | - | $734 | $593,104 | 5 | N/A | false | false |
| 11 | 9 | Pooh's Heffalump Movie | $34,675 | -22.3% | 86 | - | $403 | $622,465 | 7 | Buena Vista International | false | false |
| 12 | 10 | Robots | $33,168 | -17.7% | 95 | -2 | $349 | $1,789,452 | 12 | 20th Century Fox International | false | false |
| 13 | 11 | The Interpreter | $21,176 | -38.8% | 26 | -11 | $814 | $1,389,367 | 9 | United International Pictures | false | false |
| 14 | 12 | A Love Song for Bobby Long | $13,458 | -40.3% | 20 | - | $672 | $64,127 | 2 | Moonlight Films | false | false |
| 15 | 14 | The Consequences of Love | $12,482 | -22.7% | 12 | - | $1,040 | $117,569 | 5 | Cinemien | false | false |
| 16 | - | Your Next Life 2005 Re-release | $11,843 | - | 8 | - | $1,480 | $13,131 | 1 | Cinemien | true | false |
| 17 | 15 | What the #$*! Do We (K)now!? 2005 Re-release | $10,287 | -7% | 8 | - | $1,285 | $100,527 | 5 | Cinemien | false | false |
| 18 | 13 | Hitch | $9,812 | -39.6% | 15 | -4 | $654 | $3,821,933 | 14 | United International Pictures | false | false |
| 19 | 17 | The Assassination of Richard Nixon | $8,445 | -12.4% | 12 | - | $703 | $108,948 | 5 | Independent Films | false | false |
| 20 | - | Son of the Mask | $7,938 | - | 52 | - | $152 | $348,974 | 8 | RCV Film Distribution | false | false |
