| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar | $300,218 | -33.5% | - | - | - | $3,228,063 | 5 | United International Pictures | false | false |
| 2 | 2 | Fantastic Four | $250,016 | -28.2% | - | - | - | $1,395,329 | 3 | 20th Century Fox International | false | false |
| 3 | - | The Island | $224,173 | - | - | - | - | $224,173 | 1 | Warner Bros. | true | false |
| 4 | 4 | The Longest Yard | $173,835 | -30.3% | - | - | - | $1,009,060 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | Herbie Fully Loaded | $172,960 | +6.4% | - | - | - | $831,835 | 4 | Buena Vista International | false | false |
| 6 | 3 | War of the Worlds | $161,976 | -46% | - | - | - | $2,259,532 | 4 | United International Pictures | false | false |
| 7 | 6 | Are We There Yet? | $112,860 | -27.9% | - | - | - | $383,902 | 2 | Sony Pictures Releasing | false | false |
| 8 | 10 | Pooh's Heffalump Movie | $67,964 | -7% | - | - | - | $317,258 | 3 | Buena Vista International | false | false |
| 9 | 7 | House of Wax | $63,224 | -40.6% | - | - | - | $219,913 | 2 | Roadshow Films | false | false |
| 10 | 8 | Mr. & Mrs. Smith | $50,266 | -38% | - | - | - | $2,350,948 | 7 | 20th Century Fox International | false | false |
| 11 | 11 | A Good Woman | $46,684 | -27.6% | - | - | - | $317,842 | 4 | Hopscotch Films | false | false |
| 12 | 9 | Batman Begins | $45,173 | -41.2% | - | - | - | $1,526,569 | 6 | Warner Bros. | false | false |
| 13 | 13 | Ladies in Lavender | $35,256 | -22.1% | - | - | - | $851,501 | 8 | Icon Film Distribution | false | false |
| 14 | - | The Machinist | $33,986 | - | - | - | - | $33,986 | 1 | Rialto Distribution | true | false |
| 15 | 14 | The Sisterhood of the Traveling Pants | $21,044 | -29.1% | - | - | - | $138,069 | 3 | Warner Bros. | false | false |
| 16 | 12 | Star Wars: Episode III - Revenge of the Sith | $14,645 | -70.8% | - | - | - | $3,944,651 | 10 | 20th Century Fox International | false | false |
| 17 | - | Luther | $14,038 | - | - | - | - | $23,833 | 1 | - | true | false |
| 18 | 16 | Five Children and It | $12,123 | -22.8% | - | - | - | $71,221 | 3 | Icon Film Distribution | false | false |
| 19 | 17 | Hotel Rwanda | $11,025 | -19.6% | - | - | - | $169,373 | 6 | Roadshow Films | false | false |
| 20 | 18 | What the #$*! Do We (K)now!? 2005 Re-release | $8,486 | -11.9% | - | - | - | $109,508 | 10 | Hopscotch Films | false | false |
