| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: The Meltdown | $2,263,221 | -28.5% | 374 | -16 | $6,051 | $13,407,877 | 3 | 20th Century Fox International | false | false |
| 2 | 2 | Scary Movie 4 | $1,150,621 | -48.7% | 246 | - | $4,677 | $4,587,179 | 2 | Buena Vista International | false | false |
| 3 | - | Eight Below | $786,798 | - | 254 | - | $3,097 | $865,662 | 1 | Buena Vista International | true | false |
| 4 | 3 | Failure to Launch | $728,545 | -34.3% | 215 | -5 | $3,388 | $2,458,481 | 2 | United International Pictures | false | false |
| 5 | 5 | She's the Man | $596,736 | -9.2% | 140 | +2 | $4,262 | $3,108,874 | 3 | Roadshow Films | false | false |
| 6 | 9 | The Shaggy Dog | $556,809 | +33.2% | 230 | -16 | $2,420 | $3,692,758 | 5 | Buena Vista International | false | false |
| 7 | 6 | The World's Fastest Indian | $446,726 | -31.8% | 189 | -3 | $2,363 | $2,632,593 | 3 | Becker Film Group | false | false |
| 8 | 4 | Inside Man | $414,655 | -42.1% | 184 | -22 | $2,253 | $5,078,220 | 4 | United International Pictures | false | false |
| 9 | - | Kokoda: 39th Battalion | $399,411 | - | 94 | - | $4,249 | $441,996 | 1 | Palace Films | true | false |
| 10 | 8 | March of the Penguins | $338,102 | -30.6% | 123 | - | $2,748 | $1,826,207 | 4 | Roadshow Films | false | false |
| 11 | - | The Hills Have Eyes | $322,412 | - | 101 | - | $3,192 | $329,800 | 1 | 20th Century Fox International | true | false |
| 12 | 7 | V for Vendetta | $266,668 | -53.7% | 159 | -16 | $1,677 | $3,729,544 | 4 | Warner Bros. | false | false |
| 13 | 10 | Yours, Mine & Ours | $196,473 | +16% | 146 | -12 | $1,345 | $1,312,269 | 6 | Sony Pictures Releasing | false | false |
| 14 | 11 | Zathura: A Space Adventure | $100,304 | -8.1% | 143 | -19 | $701 | $2,138,419 | 4 | Sony Pictures Releasing | false | false |
| 15 | 12 | Water Canadian Release | $86,675 | -12.1% | 16 | - | $5,417 | $321,956 | 2 | Dendy Films | false | false |
| 16 | 14 | The Squid and the Whale | $67,608 | -15.9% | 14 | - | $4,829 | $209,083 | 2 | Sony Pictures Releasing | false | false |
| 17 | 16 | Tsotsi | $64,817 | -9.9% | 22 | - | $2,946 | $203,635 | 2 | Rialto Distribution | false | false |
| 18 | 17 | How Much Do You Love Me? | $44,734 | -15.4% | 7 | - | $6,390 | $198,044 | 2 | Palace Films | false | false |
| 19 | 13 | Walk the Line | $41,991 | -51.1% | 62 | -33 | $677 | $11,092,976 | 12 | 20th Century Fox International | false | false |
| 20 | 15 | Match Point | $39,222 | -50.3% | 36 | -9 | $1,089 | $2,892,107 | 8 | Icon Film Distribution | false | false |
