| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Da Vinci Code | $1,530,600 | -71.6% | 645 | -102 | $2,373 | $33,639,311 | 4 | Sony Pictures Releasing | false | false |
| 2 | - | The Omen | $775,966 | - | 352 | - | $2,204 | $1,330,785 | 1 | 20th Century Fox International | true | false |
| 3 | 4 | Volver | $632,211 | -56.2% | 271 | +3 | $2,332 | $6,756,659 | 4 | Warner Bros. | false | false |
| 4 | 2 | Poseidon | $631,619 | -66.4% | 328 | -19 | $1,925 | $3,227,984 | 2 | Warner Bros. | false | false |
| 5 | 3 | X-Men: The Last Stand | $538,390 | -69.8% | 261 | -178 | $2,062 | $6,293,749 | 3 | 20th Century Fox International | false | false |
| 6 | 5 | Hoodwinked! | $285,465 | -60.5% | 168 | +5 | $1,699 | $1,245,476 | 2 | 01 Distribution | false | false |
| 7 | 6 | A Prairie Home Companion | $268,268 | -44.1% | 142 | +27 | $1,889 | $951,621 | 2 | Medusa Distribuzione | false | false |
| 8 | - | American Dreamz | $216,254 | - | 100 | - | $2,162 | $216,254 | 1 | United International Pictures | true | false |
| 9 | 14 | The Valet | $58,926 | -23.9% | 17 | -6 | $3,466 | $1,156,147 | 5 | Medusa Distribuzione | false | false |
| 10 | 9 | Ice Age: The Meltdown | $53,802 | -76.1% | 65 | -23 | $827 | $23,699,119 | 8 | 20th Century Fox International | false | false |
| 11 | 11 | L'estate del mio primo bacio | $46,688 | -66.2% | 40 | -3 | $1,167 | $230,563 | 2 | 01 Distribution | false | false |
| 12 | 13 | Libero (Along the Ridge) | $43,097 | -53.9% | 37 | -1 | $1,164 | $953,795 | 6 | 01 Distribution | false | false |
| 13 | 10 | RV | $42,768 | -79.9% | 74 | -18 | $577 | $324,182 | 2 | Sony Pictures Releasing | false | false |
| 14 | 7 | One Last Dance 2006 Re-release | $38,368 | -86.7% | 50 | -116 | $767 | $1,041,160 | 3 | Eagle Pictures | false | false |
| 15 | - | Shadows in the Sun | $35,443 | - | 53 | - | $668 | $35,443 | 1 | Istituto Luce | true | false |
| 16 | 16 | Midsummer Dream | $34,902 | -26.4% | 14 | -12 | $2,493 | $149,675 | 3 | Medusa Distribuzione | false | false |
| 17 | - | The Shaggy Dog | $32,941 | - | 39 | - | $844 | $32,941 | 1 | Buena Vista International | true | false |
| 18 | 8 | The Breed | $30,541 | -87.4% | 73 | -50 | $418 | $363,330 | 2 | Medusa Distribuzione | false | false |
| 19 | - | Anthony, Warrior of God | $26,721 | - | 25 | - | $1,068 | $26,721 | 1 | 01 Distribution | true | false |
| 20 | 15 | Romance & Cigarettes | $25,463 | -60.5% | 16 | -9 | $1,591 | $1,455,348 | 6 | Nexo | false | false |
