| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Snakes on a Plane | $2,011,676 | - | 354 | - | $5,682 | $2,011,676 | 1 | Entertainment Film Distributors | true | false |
| 2 | 1 | Cars | $1,774,266 | -29.9% | 497 | -1 | $3,569 | $24,112,424 | 4 | Buena Vista International | false | false |
| 3 | 2 | Pirates of the Caribbean: Dead Man's Chest | $1,705,543 | -31.6% | 450 | -22 | $3,790 | $91,039,400 | 7 | Buena Vista International | false | false |
| 4 | 4 | Monster House | $1,609,218 | -17.3% | 425 | +1 | $3,786 | $5,834,995 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | John Tucker Must Die | $1,590,433 | - | 270 | - | $5,890 | $1,590,433 | 1 | 20th Century Fox International | true | false |
| 6 | 5 | Nacho Libre | $1,150,446 | -38.7% | 366 | - | $3,143 | $4,625,358 | 2 | United International Pictures | false | false |
| 7 | 3 | Miami Vice | $1,136,808 | -49.3% | 409 | -3 | $2,779 | $11,530,852 | 3 | United International Pictures | false | false |
| 8 | 6 | Kabhi Alvida Naa Kehna | $576,285 | -59.3% | 61 | +1 | $9,447 | $2,708,087 | 2 | Yash Raj Films | false | false |
| 9 | 11 | Garfield: A Tail of Two Kitties | $557,683 | -7.2% | 343 | - | $1,625 | $8,919,635 | 5 | 20th Century Fox International | false | false |
| 10 | 7 | The Break-Up | $536,682 | -48.8% | 295 | +259 | $1,819 | $18,147,171 | 5 | United International Pictures | false | false |
| 11 | - | Harsh Times | $529,639 | - | 217 | - | $2,440 | $529,639 | 1 | Pathé | true | false |
| 12 | - | A Scanner Darkly | $457,006 | - | 104 | - | $4,394 | $457,006 | 1 | Warner Bros. | true | false |
| 13 | 10 | Superman Returns | $380,028 | -50.6% | 193 | -83 | $1,969 | $29,013,220 | 6 | Warner Bros. | false | false |
| 14 | 8 | My Super Ex-Girlfriend | $371,666 | -59.5% | 255 | -36 | $1,457 | $4,792,296 | 3 | 20th Century Fox International | false | false |
| 15 | 12 | Stormbreaker | $365,027 | -30.4% | 291 | -35 | $1,254 | $11,055,202 | 5 | Entertainment Film Distributors | false | false |
| 16 | 9 | Lady in the Water | $250,500 | -70.7% | 271 | -16 | $924 | $1,771,668 | 2 | Warner Bros. | false | false |
| 17 | 13 | The Ant Bully | $245,212 | -38% | 308 | -62 | $796 | $2,700,436 | 3 | Warner Bros. | false | false |
| 18 | 14 | Over the Hedge | $239,906 | -17.1% | 238 | -36 | $1,008 | $23,356,509 | 8 | United International Pictures | false | false |
| 19 | 15 | The Wind that Shakes the Barley | $137,331 | -17.5% | 89 | +13 | $1,543 | $6,323,807 | 9 | Pathé | false | false |
| 20 | 16 | The Notorious Bettie Page | $36,491 | -9.6% | 16 | +1 | $2,280 | $202,688 | 3 | Icon Film Distribution | false | false |
| 21 | - | Deep Sea | $36,391 | - | 1 | - | $36,391 | $1,856,993 | 25 | IMAX | false | false |
| 22 | - | Three Times | $18,364 | - | 4 | - | $4,591 | $100,243 | 3 | Artificial Eye | false | false |
| 23 | - | Akeelah and the Bee | $15,712 | - | 106 | - | $148 | $15,712 | 1 | Lionsgate Films | true | false |
| 24 | 19 | Omkara | $14,486 | -51.1% | 18 | -8 | $804 | $501,441 | 4 | Eros Worldwide | false | false |
| 25 | - | Thank You for Smoking | $14,450 | - | 10 | - | $1,445 | $2,040,109 | 10 | 20th Century Fox International | false | false |
| 26 | 17 | Little Fish | $13,630 | -59.6% | 7 | -11 | $1,947 | $396,079 | 5 | Tartan | false | false |
| 27 | - | United 93 | $12,338 | - | 17 | - | $725 | $5,272,238 | 12 | United International Pictures | false | false |
| 28 | - | The Third Man 2006 Re-release | $10,372 | - | 1 | - | $10,372 | $41,365 | 2 | Optimum Releasing | false | false |
| 29 | 20 | Angel-A | $10,013 | -65.2% | 13 | -10 | $770 | $322,947 | 4 | Optimum Releasing | false | false |
| 30 | - | Curious George | $9,498 | - | 64 | - | $148 | $2,752,505 | 13 | United International Pictures | false | false |
| 31 | - | The Da Vinci Code | $7,993 | - | 4 | - | $1,998 | $57,132,236 | 14 | Sony Pictures Releasing | false | false |
| 32 | - | Friends with Money | $7,959 | - | 2 | - | $3,979 | $880,308 | 13 | Sony Pictures Releasing | false | false |
| 33 | - | Innocent Voices | $7,679 | - | 5 | - | $1,535 | $38,614 | 2 | The Works UK Distribution | false | false |
| 34 | - | Stray Dogs 2006 Re-release | $6,822 | - | 2 | - | $3,411 | $6,822 | 1 | Artificial Eye | true | false |
| 35 | - | The Cave of the Yellow Dog | $6,603 | - | 11 | - | $600 | $206,443 | 8 | Tartan | false | false |
| 36 | - | Just My Luck | $5,748 | - | 5 | - | $1,149 | $3,882,562 | 8 | 20th Century Fox International | false | false |
| 37 | - | Heading South | $5,317 | - | 8 | - | $664 | $296,825 | 7 | Soda Pictures | false | false |
| 38 | - | Shaadi Karke Phas Gaya Yaar | $5,210 | - | 10 | - | $521 | $109,216 | 3 | Eros Worldwide | false | false |
| 39 | - | Atomised | $5,095 | - | 11 | - | $463 | $183,921 | 6 | Momentum Pictures | false | false |
| 40 | - | Renaissance | $4,747 | - | 5 | - | $949 | $92,439 | 4 | Pathé | false | false |
| 41 | - | Paper Clips 2006 Re-release | $4,651 | - | 2 | - | $2,325 | $24,003 | 3 | Lionsgate Films | false | false |
| 42 | - | Alpha Male | $4,533 | - | 4 | - | $1,133 | $33,699 | 2 | Verve Pictures | false | false |
| 43 | - | The Death of Mr. Lazarescu | $4,427 | - | 4 | - | $1,106 | $68,264 | 6 | Tartan | false | false |
| 44 | - | X-Men: The Last Stand | $4,299 | - | 2 | - | $2,149 | $35,973,156 | 13 | 20th Century Fox International | false | false |
| 45 | - | Wah-Wah | $3,871 | - | 3 | - | $1,290 | $356,015 | 12 | Lionsgate Films | false | false |
| 46 | - | Wilderness | $3,765 | - | 8 | - | $470 | $39,535 | 2 | Momentum Pictures | false | false |
| 47 | - | Stay Alive | $3,739 | - | 8 | - | $467 | $763,551 | 4 | United International Pictures | false | false |
| 48 | - | The Protector | $2,817 | - | 5 | - | $563 | $174,576 | 4 | Contender Entertainment Group | false | false |
| 49 | - | Rebecca 2006 Re-release | $2,799 | - | 2 | - | $1,399 | $50,700 | 8 | British Film Institute (BFI) | false | false |
| 50 | - | The Lake House | $2,125 | - | 3 | - | $708 | $5,278,471 | 9 | Warner Bros. | false | false |
