| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Mrs Palfrey at the Claremont | $117,894 | +29.2% | 39 | +6 | $3,022 | $556,196 | 4 | Rialto Distribution | false | false |
| 2 | 1 | Little Man | $99,684 | -41.4% | 43 | -1 | $2,318 | $294,548 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Lady in the Water | $68,743 | - | 44 | - | $1,562 | $68,743 | 1 | Warner Bros. | true | false |
| 4 | 3 | Silent Hill | $50,583 | -41.1% | 29 | +1 | $1,744 | $165,547 | 2 | United International Pictures | false | false |
| 5 | - | DOA: Dead or Alive | $44,858 | - | 20 | - | $2,242 | $44,858 | 1 | United International Pictures | true | false |
| 6 | - | Wah-Wah | $44,687 | - | 11 | - | $4,062 | $74,517 | 1 | Hopscotch Films | true | false |
| 7 | 4 | Snakes on a Plane | $40,886 | -40.9% | 41 | - | $997 | $281,126 | 3 | Roadshow Films | false | false |
| 8 | - | Clerks II | $37,715 | - | 26 | - | $1,450 | $37,715 | 1 | Roadshow Films | true | false |
| 9 | - | Monster House | $34,407 | - | 34 | - | $1,011 | $34,407 | - | Sony Pictures Releasing | - | false |
| 10 | 8 | Thank You for Smoking | $32,701 | -24% | 10 | - | $3,270 | $170,677 | 3 | 20th Century Fox International | false | false |
| 11 | 6 | Hoodwinked! | $32,424 | -30.5% | 45 | -5 | $720 | $612,611 | 6 | Roadshow Films | false | false |
| 12 | 7 | Pirates of the Caribbean: Dead Man's Chest | $31,753 | -28.4% | 44 | -10 | $721 | $4,374,343 | 10 | Buena Vista International | false | false |
| 13 | 5 | My Super Ex-Girlfriend | $25,912 | -46.7% | 34 | -6 | $762 | $355,870 | 4 | 20th Century Fox International | false | false |
| 14 | 9 | United 93 | $23,440 | -32.7% | 23 | -2 | $1,019 | $220,867 | 4 | United International Pictures | false | false |
| 15 | - | The Three Burials of Melquiades Estrada | $18,001 | - | 8 | - | $2,250 | $29,888 | 1 | Madman Entertainment | true | false |
| 16 | 14 | As It Is in Heaven | $17,240 | +25.7% | 14 | - | $1,231 | $411,148 | 37 | Rialto Distribution | false | false |
| 17 | 10 | Fearless | $17,047 | -51% | 19 | -1 | $897 | $151,467 | 3 | United International Pictures | false | false |
| 18 | 11 | Miami Vice | $13,090 | -56.5% | 27 | -9 | $484 | $582,564 | 5 | United International Pictures | false | false |
| 19 | 13 | Take the Lead | $12,738 | -30.9% | 31 | -7 | $410 | $1,180,086 | 11 | Roadshow Films | false | false |
| 20 | 12 | You, Me and Dupree | $10,121 | -55.4% | 25 | -10 | $404 | $726,307 | 7 | United International Pictures | false | false |
