| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Click | $3,356,944 | - | 402 | - | $8,350 | $3,356,944 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Hoodwinked! | $3,295,946 | - | 435 | - | $7,576 | $3,295,946 | 1 | Momentum Pictures | true | false |
| 3 | - | World Trade Center | $3,115,067 | - | 411 | - | $7,579 | $3,115,067 | 1 | United International Pictures | true | false |
| 4 | 1 | Children of Men | $1,787,905 | -26.7% | 372 | +2 | $4,806 | $5,563,942 | 2 | United International Pictures | false | false |
| 5 | 2 | The Queen | $1,500,704 | -13% | 345 | -4 | $4,349 | $8,059,586 | 3 | Pathé | false | false |
| 6 | 3 | Talladega Nights: The Ballad of Ricky Bobby | $627,803 | -51.3% | 341 | -63 | $1,841 | $5,451,934 | 3 | Sony Pictures Releasing | false | false |
| 7 | 6 | Little Miss Sunshine | $531,487 | -24.2% | 171 | -2 | $3,108 | $4,100,340 | 4 | 20th Century Fox International | false | false |
| 8 | 4 | Little Man | $427,387 | -50.8% | 272 | -43 | $1,571 | $7,557,340 | 5 | Sony Pictures Releasing | false | false |
| 9 | 5 | You, Me and Dupree | $362,849 | -55.6% | 247 | -97 | $1,469 | $14,718,859 | 6 | United International Pictures | false | false |
| 10 | 7 | The Black Dahlia | $236,805 | -62.8% | 169 | -161 | $1,401 | $2,936,490 | 3 | Entertainment Film Distributors | false | false |
| 11 | 9 | Dirty Sanchez: The Movie | $207,104 | -57.6% | 188 | -20 | $1,101 | $973,024 | 2 | Pathé | false | false |
| 12 | - | Life and Lyrics | $178,813 | - | 70 | - | $2,554 | $178,813 | 1 | United International Pictures | true | false |
| 13 | 12 | An Inconvenient Truth | $168,175 | -27% | 66 | +2 | $2,548 | $816,121 | 3 | United International Pictures | false | false |
| 14 | 11 | Monster House | $144,296 | -39.4% | 263 | -62 | $548 | $12,033,803 | 8 | Sony Pictures Releasing | false | false |
| 15 | 8 | Trust the Man | $136,712 | -74.4% | 196 | -67 | $697 | $995,692 | 2 | Icon Film Distribution | false | false |
| 16 | 14 | Cars | $130,742 | -34.2% | 225 | -70 | $581 | $30,225,967 | 10 | Buena Vista International | false | false |
| 17 | 10 | Clerks II | $124,674 | -70.6% | 165 | -80 | $755 | $785,520 | 2 | United International Pictures | false | false |
| 18 | 15 | Volver | $124,196 | -33.4% | 53 | -14 | $2,343 | $4,624,250 | 6 | Pathé | false | false |
| 19 | 18 | Garfield: A Tail of Two Kitties | $103,342 | -29.2% | 203 | -48 | $509 | $11,953,337 | 11 | 20th Century Fox International | false | false |
| 20 | 17 | Pirates of the Caribbean: Dead Man's Chest | $83,793 | -42.7% | 78 | -48 | $1,074 | $97,027,561 | 13 | Buena Vista International | false | false |
