| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: Dead Man's Chest | $1,976,765 | -52.3% | 554 | -291 | $3,568 | $21,962,465 | 3 | Buena Vista International | false | false |
| 2 | 2 | The Break-Up | $1,124,039 | -35.1% | 290 | -7 | $3,875 | $3,535,896 | 2 | United International Pictures | false | false |
| 3 | - | The Black Dahlia | $1,079,985 | - | 318 | - | $3,396 | $1,079,985 | 1 | 01 Distribution | true | false |
| 4 | - | Click | $885,687 | - | 194 | - | $4,565 | $885,687 | 1 | Sony Pictures Releasing | true | false |
| 5 | 3 | Perfume: The Story of a Murderer | $755,256 | -28% | 325 | -10 | $2,323 | $2,335,396 | 2 | Medusa Distribuzione | false | false |
| 6 | - | Lady in the Water | $472,610 | - | 174 | - | $2,716 | $472,610 | 1 | Warner Bros. | true | false |
| 7 | 4 | Cars | $460,907 | -37.6% | 209 | -60 | $2,205 | $15,897,512 | 6 | Buena Vista International | false | false |
| 8 | 6 | Golden Door | $334,540 | -10% | 119 | +9 | $2,811 | $912,927 | 2 | 01 Distribution | false | false |
| 9 | - | Baciami piccina | $270,227 | - | 170 | - | $1,589 | $271,393 | 1 | Medusa Distribuzione | true | false |
| 10 | 5 | The Queen | $196,437 | -50% | 105 | -83 | $1,870 | $1,859,417 | 3 | BIM Distribuzione | false | false |
| 11 | 10 | Little Miss Sunshine | $172,828 | +5% | 64 | -4 | $2,700 | $446,247 | 2 | 20th Century Fox International | false | false |
| 12 | - | Clerks II | $117,685 | - | 115 | - | $1,023 | $117,685 | 1 | Mikado Film | true | false |
| 13 | 7 | The Missing Star | $100,028 | -65.2% | 70 | -129 | $1,428 | $2,648,820 | 4 | 01 Distribution | false | false |
| 14 | - | Snakes on a Plane | $84,356 | - | 105 | - | $803 | $84,356 | 1 | Mediafilm | true | false |
| 15 | 11 | The Ant Bully | $79,477 | -51.7% | 131 | -16 | $606 | $288,378 | 2 | Warner Bros. | false | false |
| 16 | 14 | Thank You for Smoking | $58,539 | -36% | 16 | -24 | $3,658 | $1,520,188 | 5 | Lucky Red | false | false |
| 17 | 8 | The Stone Merchant | $55,553 | -69.6% | 34 | -120 | $1,633 | $984,776 | 3 | Medusa Distribuzione | false | false |
| 18 | 12 | Lucky Number Slevin | $40,492 | -72.9% | 31 | -42 | $1,306 | $4,486,090 | 7 | Moviemax | false | false |
| 19 | 9 | Superman Returns | $35,405 | -78.7% | 31 | -107 | $1,142 | $6,859,237 | 5 | Warner Bros. | false | false |
| 20 | 17 | Belle toujours | $12,033 | -45.2% | 8 | -7 | $1,504 | $171,009 | 4 | Mikado Film | false | false |
