| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Devil Wears Prada | $3,559,030 | - | 417 | - | $8,534 | $3,559,030 | 1 | 20th Century Fox International | true | false |
| 2 | - | World Trade Center | $1,980,379 | - | 325 | - | $6,093 | $1,980,379 | 1 | United International Pictures | true | false |
| 3 | 2 | Scoop | $1,022,504 | -31.8% | 351 | -1 | $2,913 | $3,144,859 | 2 | Medusa Distribuzione | false | false |
| 4 | 1 | Miami Vice | $817,453 | -47.8% | 292 | -6 | $2,799 | $2,968,698 | 2 | United International Pictures | false | false |
| 5 | 3 | Pirates of the Caribbean: Dead Man's Chest | $490,352 | -56.8% | 219 | -128 | $2,239 | $24,048,628 | 5 | Buena Vista International | false | false |
| 6 | 5 | Click | $372,270 | -46.9% | 154 | -38 | $2,417 | $2,458,704 | 3 | Sony Pictures Releasing | false | false |
| 7 | - | Monster House | $369,450 | - | 195 | - | $1,894 | $369,450 | 1 | Sony Pictures Releasing | true | false |
| 8 | - | N (Io e Napoleone) | $325,457 | - | 13 | - | $25,035 | $325,457 | 1 | Medusa Distribuzione | true | false |
| 9 | 8 | Golden Door | $291,607 | -22.5% | 116 | -6 | $2,513 | $1,954,463 | 4 | 01 Distribution | false | false |
| 10 | 4 | The Break-Up | $272,134 | -62.3% | 151 | -107 | $1,802 | $5,019,440 | 4 | United International Pictures | false | false |
| 11 | 6 | The Black Dahlia | $237,576 | -63.5% | 151 | -166 | $1,573 | $2,617,360 | 3 | 01 Distribution | false | false |
| 12 | 7 | Perfume: The Story of a Murderer | $181,066 | -59.1% | 136 | -71 | $1,331 | $3,461,857 | 4 | Medusa Distribuzione | false | false |
| 13 | 10 | Cars | $127,450 | -53% | 115 | -65 | $1,108 | $16,204,509 | 8 | Buena Vista International | false | false |
| 14 | 11 | Little Miss Sunshine | $105,620 | -31.1% | 53 | -13 | $1,992 | $866,038 | 4 | 20th Century Fox International | false | false |
| 15 | 12 | Baciami piccina | $54,738 | -63.2% | 54 | -72 | $1,013 | $632,826 | 3 | Medusa Distribuzione | false | false |
| 16 | 17 | Water 2006 Re-release | $52,141 | +12.9% | 18 | +1 | $2,896 | $133,912 | 2 | Warner Bros. | false | false |
| 17 | 13 | The Queen | $52,001 | -55.6% | 36 | -46 | $1,444 | $2,136,143 | 5 | BIM Distribuzione | false | false |
| 18 | 9 | Lady in the Water | $46,840 | -83.1% | 60 | -113 | $780 | $1,067,315 | 3 | Warner Bros. | false | false |
| 19 | 14 | Comedy of Power | $34,619 | -42.8% | 26 | -18 | $1,331 | $129,200 | 2 | BIM Distribuzione | false | false |
| 20 | - | 12:08 East of Bucharest | $29,085 | - | 12 | - | $2,423 | $63,712 | 2 | Istituto Luce | false | false |
