| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Devil Wears Prada | $3,334,980 | -6.3% | 420 | +3 | $7,940 | $8,501,752 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | World Trade Center | $1,555,557 | -21.5% | 333 | +8 | $4,671 | $4,307,526 | 2 | United International Pictures | false | false |
| 3 | - | The Unknown Woman | $942,542 | - | 297 | - | $3,173 | $942,542 | 1 | Medusa Distribuzione | true | false |
| 4 | 3 | Scoop | $711,400 | -30.4% | 230 | -121 | $3,093 | $4,263,062 | 3 | Medusa Distribuzione | false | false |
| 5 | 4 | Miami Vice | $535,804 | -34.5% | 195 | -97 | $2,747 | $3,797,359 | 3 | United International Pictures | false | false |
| 6 | - | The Hoax | $440,432 | - | 293 | - | $1,503 | $440,432 | 1 | Eagle Pictures | true | false |
| 7 | 8 | N (Io e Napoleone) | $376,336 | +15.6% | 207 | +194 | $1,818 | $869,319 | 2 | Medusa Distribuzione | false | false |
| 8 | - | Fur: An Imaginary Portrait of Diane Arbus | $319,618 | - | 195 | - | $1,639 | $319,618 | 1 | Nexo | true | false |
| 9 | 5 | Pirates of the Caribbean: Dead Man's Chest | $294,616 | -39.9% | 130 | -89 | $2,266 | $24,664,790 | 6 | Buena Vista International | false | false |
| 10 | 7 | Monster House | $292,973 | -20.7% | 175 | -20 | $1,674 | $760,348 | 2 | Sony Pictures Releasing | false | false |
| 11 | 6 | Click | $252,889 | -32.1% | 95 | -59 | $2,661 | $2,841,039 | 4 | Sony Pictures Releasing | false | false |
| 12 | 9 | Golden Door | $206,736 | -29.1% | 97 | -19 | $2,131 | $2,293,156 | 5 | 01 Distribution | false | false |
| 13 | 10 | The Break-Up | $94,036 | -65.4% | 55 | -96 | $1,709 | $5,233,534 | 5 | United International Pictures | false | false |
| 14 | 14 | Little Miss Sunshine | $93,814 | -11.2% | 34 | -19 | $2,759 | $1,016,864 | 5 | 20th Century Fox International | false | false |
| 15 | 13 | Cars | $92,513 | -27.4% | 61 | -54 | $1,516 | $16,456,342 | 9 | Buena Vista International | false | false |
| 16 | 11 | The Black Dahlia | $89,179 | -62.5% | 55 | -96 | $1,621 | $2,822,578 | 4 | 01 Distribution | false | false |
| 17 | 12 | Perfume: The Story of a Murderer | $72,932 | -59.7% | 39 | -97 | $1,870 | $3,639,053 | 5 | Medusa Distribuzione | false | false |
| 18 | - | A Scanner Darkly | $69,418 | - | 43 | - | $1,614 | $69,418 | 1 | Warner Bros. | true | false |
| 19 | 16 | Water 2006 Re-release | $52,136 | <0.1% | 17 | -1 | $3,066 | $219,127 | 3 | Warner Bros. | false | false |
| 20 | - | Down in the Valley | $43,793 | - | 116 | - | $377 | $43,793 | 1 | Buena Vista International | true | false |
