| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Departed | $1,034,349 | -24% | 217 | -59 | $4,766 | $5,471,006 | 3 | Warner Bros. | false | false |
| 2 | - | The Grudge 2 | $559,554 | - | 157 | - | $3,564 | $559,554 | 1 | Roadshow Films | true | false |
| 3 | 3 | The Devil Wears Prada | $528,650 | -27.9% | 284 | -13 | $1,861 | $11,329,249 | 6 | 20th Century Fox International | false | false |
| 4 | 4 | Little Miss Sunshine | $495,561 | -17.8% | 133 | +1 | $3,726 | $2,498,463 | 3 | 20th Century Fox International | false | false |
| 5 | 2 | BoyTown | $478,858 | -36.7% | 197 | -5 | $2,430 | $1,463,939 | 2 | Roadshow Films | false | false |
| 6 | 5 | Children of Men | $437,498 | -27.2% | 165 | +1 | $2,651 | $1,276,743 | 2 | United International Pictures | false | false |
| 7 | 8 | Kenny | $257,026 | -9.6% | 114 | -10 | $2,254 | $4,673,105 | 11 | Madman Entertainment | false | false |
| 8 | 6 | Crank | $230,053 | -29.7% | 136 | +3 | $1,691 | $705,463 | 2 | Hoyts Distribution | false | false |
| 9 | 7 | Step Up | $197,702 | -34.6% | 140 | -4 | $1,412 | $4,615,724 | 5 | United International Pictures | false | false |
| 10 | - | Trust the Man | $165,484 | - | 102 | - | $1,622 | $165,484 | 1 | Icon Film Distribution | true | false |
| 11 | 9 | Garfield: A Tail of Two Kitties | $122,255 | -29.2% | 193 | -6 | $633 | $5,170,340 | 8 | 20th Century Fox International | false | false |
| 12 | 12 | An Inconvenient Truth | $117,476 | +0.4% | 60 | +8 | $1,957 | $2,399,035 | 7 | United International Pictures | false | false |
| 13 | - | Mrs Palfrey at the Claremont | $81,234 | - | 26 | - | $3,124 | $81,234 | 1 | Rialto Distribution | true | false |
| 14 | - | Suburban Mayhem | $79,400 | - | 38 | - | $2,089 | $79,895 | 1 | Icon Film Distribution | true | false |
| 15 | 13 | Monster House | $66,473 | -42.1% | 115 | -62 | $578 | $6,031,131 | 7 | Sony Pictures Releasing | false | false |
| 16 | - | Fast Food Nation | $65,141 | - | 61 | - | $1,067 | $65,141 | 1 | Dendy Films | true | false |
| 17 | 15 | Don | $51,940 | -30.2% | 12 | - | $4,328 | $169,032 | 2 | MG Distribution | false | false |
| 18 | 10 | The Covenant | $51,707 | -61.9% | 80 | -25 | $646 | $655,948 | 3 | Sony Pictures Releasing | false | false |
| 19 | 17 | A Prairie Home Companion | $45,462 | -37.1% | 40 | +5 | $1,136 | $449,447 | 4 | Hoyts Distribution | false | false |
| 20 | 11 | World Trade Center | $43,072 | -67.5% | 100 | -94 | $430 | $1,669,623 | 4 | United International Pictures | false | false |
