| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | The Departed | $1,981,503 | -3.9% | 422 | +381 | $4,695 | $6,172,581 | 2 | Medusa Distribuzione | false | false |
| 2 | 1 | Over the Hedge | $1,825,934 | -12.1% | 450 | -2 | $4,057 | $5,936,404 | 2 | United International Pictures | false | false |
| 3 | 3 | The Devil Wears Prada | $1,451,514 | -23.8% | 313 | -75 | $4,637 | $14,683,299 | 4 | 20th Century Fox International | false | false |
| 4 | - | The Lazarus Child | $879,651 | - | 250 | - | $3,518 | $879,651 | 1 | Eagle Pictures | true | false |
| 5 | 6 | Babel | $642,454 | +9% | 256 | -14 | $2,509 | $1,909,009 | 2 | 01 Distribution | false | false |
| 6 | 4 | The Unknown Woman | $547,708 | -21.9% | 233 | -62 | $2,350 | $3,260,758 | 3 | Medusa Distribuzione | false | false |
| 7 | 5 | World Trade Center | $433,887 | -37% | 166 | -84 | $2,613 | $6,527,644 | 4 | United International Pictures | false | false |
| 8 | - | Trust the Man | $372,038 | - | 100 | - | $3,720 | $374,345 | 1 | Moviemax | true | false |
| 9 | - | Our Country | $343,042 | - | 140 | - | $2,450 | $343,159 | 1 | 01 Distribution | true | false |
| 10 | 7 | Scoop | $207,001 | -35.6% | 71 | -53 | $2,915 | $5,324,667 | 5 | Medusa Distribuzione | false | false |
| 11 | - | Secret Journey | $204,190 | - | 102 | - | $2,001 | $206,326 | 1 | Medusa Distribuzione | true | false |
| 12 | 8 | Fascisti su Marte | $176,841 | -2.2% | 68 | +15 | $2,600 | $597,158 | 2 | Fandango | false | false |
| 13 | - | Any Reason Not to Marry? | $120,332 | - | 54 | - | $2,228 | $120,332 | 1 | Warner Bros. | true | false |
| 14 | - | Salvatore - Questa è la vita | $106,327 | - | 54 | - | $1,969 | $176,564 | 1 | Buena Vista International | true | false |
| 15 | 12 | Golden Door | $73,669 | -31.4% | 36 | -18 | $2,046 | $2,681,705 | 7 | 01 Distribution | false | false |
| 16 | 9 | Those Happy Days | $59,290 | -67% | 84 | -40 | $705 | $439,050 | 2 | Filmauro | false | false |
| 17 | 11 | N (Io e Napoleone) | $54,698 | -52.6% | 30 | -28 | $1,823 | $1,253,693 | 4 | Medusa Distribuzione | false | false |
| 18 | 18 | Little Miss Sunshine | $50,206 | -2.6% | 18 | +1 | $2,789 | $1,228,378 | 7 | 20th Century Fox International | false | false |
| 19 | 13 | Pirates of the Caribbean: Dead Man's Chest | $48,280 | -50.7% | 36 | -26 | $1,341 | $25,164,472 | 8 | Buena Vista International | false | false |
| 20 | - | Talladega Nights: The Ballad of Ricky Bobby | $30,062 | - | 30 | - | $1,002 | $30,062 | 1 | Sony Pictures Releasing | true | false |
