| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Casino Royale | $5,383,683 | - | 401 | - | $13,425 | $5,383,683 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Borat | $1,101,518 | -53.6% | 279 | -13 | $3,948 | $10,647,766 | 3 | 20th Century Fox International | false | false |
| 3 | - | Charlotte's Web | $971,560 | - | 346 | - | $2,807 | $989,355 | 1 | United International Pictures | true | false |
| 4 | 2 | Open Season | $691,952 | -31.5% | 231 | -1 | $2,995 | $2,037,099 | 2 | Sony Pictures Releasing | false | false |
| 5 | 5 | The Santa Clause 3: The Escape Clause | $373,343 | -32.6% | 212 | -13 | $1,761 | $3,008,374 | 4 | Buena Vista International | false | false |
| 6 | 3 | The Prestige | $276,042 | -56.4% | 183 | -13 | $1,508 | $3,858,313 | 4 | Warner Bros. | false | false |
| 7 | 4 | The Guardian | $248,596 | -58.2% | 207 | -1 | $1,200 | $1,080,003 | 2 | Buena Vista International | false | false |
| 8 | 11 | Little Miss Sunshine | $85,447 | -36.7% | 84 | -19 | $1,017 | $4,665,805 | 9 | 20th Century Fox International | false | false |
| 9 | 7 | Unaccompanied Minors | $85,276 | -45.9% | 104 | - | $819 | $298,018 | 2 | Roadshow Films | false | false |
| 10 | 6 | Jackass Number Two | $69,052 | -67.3% | 79 | -99 | $874 | $4,364,786 | 5 | United International Pictures | false | false |
| 11 | 8 | The Descent | $56,255 | -62.2% | 79 | -26 | $712 | $544,028 | 3 | Icon Film Distribution | false | false |
| 12 | 10 | The Departed | $54,246 | -60.7% | 51 | -36 | $1,063 | $8,868,606 | 9 | Warner Bros. | false | false |
| 13 | 12 | Deck the Halls | $50,495 | -61.3% | 136 | -17 | $371 | $509,743 | 3 | 20th Century Fox International | false | false |
| 14 | 16 | The Nativity Story | $47,115 | -44.6% | 108 | - | $436 | $189,845 | 2 | Roadshow Films | false | false |
| 15 | 9 | Saw III | $38,066 | -72.8% | 36 | -86 | $1,057 | $5,156,279 | 6 | Hoyts Distribution | false | false |
| 16 | 18 | Kenny | $35,247 | -38% | 36 | -33 | $979 | $5,903,451 | 17 | Madman Entertainment | false | false |
| 17 | 15 | The Black Dahlia | $33,460 | -61.2% | 44 | -8 | $760 | $344,324 | 3 | Roadshow Films | false | false |
| 18 | - | Baabul | $33,382 | - | 7 | - | $4,768 | $33,382 | 1 | Saini Enterprises | true | false |
| 19 | 13 | A Good Year | $31,497 | -74.2% | 44 | -113 | $715 | $2,482,902 | 5 | 20th Century Fox International | false | false |
| 20 | 19 | A Scanner Darkly | $30,288 | -44.3% | 18 | - | $1,682 | $110,851 | 2 | Warner Bros. | false | false |
