| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Casino Royale | $1,012,190 | -21.5% | 132 | - | $7,668 | $4,851,143 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | Happy Feet | $687,840 | - | 169 | - | $4,070 | $797,386 | 1 | Warner Bros. | true | false |
| 3 | 2 | Crusade in Jeans | $244,630 | -15% | 134 | +131 | $1,825 | $1,769,725 | 4 | Benelux Film Distributors | false | false |
| 4 | - | Perfume: The Story of a Murderer | $204,044 | - | 49 | - | $4,164 | $227,027 | 1 | RCV Film Distribution | true | false |
| 5 | 3 | The Departed | $160,166 | -23.9% | 61 | +57 | $2,625 | $1,938,461 | 5 | Warner Bros. | false | false |
| 6 | 4 | Flushed Away | $130,937 | -37.3% | 163 | +1 | $803 | $470,154 | 2 | United International Pictures | false | false |
| 7 | 6 | Black Book | $126,401 | -19.3% | 90 | -2 | $1,404 | $8,957,272 | 13 | A-Film Distribution | false | false |
| 8 | 5 | Borat | $119,955 | -33.4% | 65 | - | $1,845 | $2,963,171 | 6 | 20th Century Fox International | false | false |
| 9 | 7 | The Queen | $78,143 | -10.8% | 23 | - | $3,397 | $223,350 | 2 | A-Film Distribution | false | false |
| 10 | 8 | Babel | $64,050 | -25.1% | 29 | -7 | $2,208 | $1,080,678 | 6 | Independent Films | false | false |
| 11 | 9 | The Devil Wears Prada | $40,355 | -14.9% | 43 | -21 | $938 | $4,035,457 | 9 | 20th Century Fox International | false | false |
| 12 | 12 | The Page Turner | $35,249 | +5.6% | 17 | - | $2,073 | $101,358 | 2 | Benelux Film Distributors | false | false |
| 13 | 13 | Dhoom 2 | $25,068 | -17.8% | 3 | - | $8,356 | $66,441 | 2 | - | false | false |
| 14 | 10 | XTC Just Don't Do It | $24,056 | -37.3% | 50 | -27 | $481 | $2,825,558 | 10 | RCV Film Distribution | false | false |
| 15 | 18 | Waiter | $17,261 | +13.2% | 15 | -3 | $1,150 | $825,829 | 11 | A-Film Distribution | false | false |
| 16 | 16 | An Inconvenient Truth | $15,251 | -16.6% | 23 | +4 | $663 | $463,946 | 9 | United International Pictures | false | false |
| 17 | 11 | The Texas Chainsaw Massacre: The Beginning | $14,185 | -58.9% | 17 | -9 | $834 | $261,387 | 4 | RCV Film Distribution | false | false |
| 18 | 15 | Little Miss Sunshine | $12,704 | -31.3% | 13 | - | $977 | $301,143 | 7 | 20th Century Fox International | false | false |
| 19 | 19 | The Science of Sleep | $10,666 | -29% | 10 | - | $1,066 | $64,042 | 3 | A-Film Distribution | false | false |
| 20 | - | The Nativity Story | $10,028 | - | 33 | - | $303 | $10,028 | 1 | Benelux Film Distributors | true | false |
