| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Casino Royale | $620,941 | -38.7% | 131 | -1 | $4,740 | $5,661,104 | 4 | Sony Pictures Releasing | false | false |
| 2 | 2 | Happy Feet | $532,639 | -22.6% | 170 | +1 | $3,133 | $1,426,315 | 2 | Warner Bros. | false | false |
| 3 | - | The Holiday | $483,047 | - | 94 | - | $5,138 | $606,866 | 1 | United International Pictures | true | false |
| 4 | - | Eragon | $328,533 | - | 113 | - | $2,907 | $328,533 | 1 | 20th Century Fox International | true | false |
| 5 | - | Deja Vu | $322,335 | - | 70 | - | $4,604 | $355,996 | 1 | Buena Vista International | true | false |
| 6 | 4 | Perfume: The Story of a Murderer | $147,985 | -27.5% | 49 | - | $3,020 | $445,200 | 2 | RCV Film Distribution | false | false |
| 7 | 3 | Crusade in Jeans | $145,850 | -40.4% | 131 | -3 | $1,113 | $1,899,146 | 5 | Benelux Film Distributors | false | false |
| 8 | - | Happy Family | $130,782 | - | 57 | - | $2,294 | $130,782 | 1 | RCV Film Distribution | true | false |
| 9 | 6 | Flushed Away | $88,711 | -32.2% | 163 | - | $544 | $571,215 | 3 | United International Pictures | false | false |
| 10 | 5 | The Departed | $62,593 | -60.9% | 38 | -23 | $1,647 | $2,014,351 | 6 | Warner Bros. | false | false |
| 11 | 9 | The Queen | $59,232 | -24.2% | 23 | - | $2,575 | $302,116 | 3 | A-Film Distribution | false | false |
| 12 | - | Plop in de stad | $48,168 | - | 100 | - | $481 | $57,350 | 1 | Independent Films | true | false |
| 13 | 10 | Babel | $46,497 | -27.4% | 19 | -10 | $2,447 | $1,132,316 | 7 | Independent Films | false | false |
| 14 | 7 | Black Book | $35,022 | -72.3% | 59 | -31 | $593 | $8,947,168 | 14 | A-Film Distribution | false | false |
| 15 | 12 | The Page Turner | $30,375 | -13.8% | 18 | +1 | $1,687 | $130,792 | 3 | Benelux Film Distributors | false | false |
| 16 | 8 | Borat | $26,591 | -77.8% | 21 | -44 | $1,266 | $2,997,541 | 7 | 20th Century Fox International | false | false |
| 17 | 19 | The Science of Sleep | $9,854 | -7.6% | 9 | -1 | $1,094 | $76,842 | 4 | A-Film Distribution | false | false |
| 18 | 16 | An Inconvenient Truth | $8,838 | -42% | 23 | - | $384 | $474,239 | 10 | United International Pictures | false | false |
| 19 | 18 | Little Miss Sunshine | $8,810 | -30.7% | 12 | -1 | $734 | $311,999 | 8 | 20th Century Fox International | false | false |
| 20 | - | A Christmoose Carol 2006 Re-release | $7,116 | - | 13 | - | $547 | $9,448 | 1 | Buena Vista International | true | false |
