| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum | $10,128,399 | - | 784 | - | $12,918 | $10,128,399 | 1 | 20th Century Fox International | true | false |
| 2 | - | Deja Vu | $3,353,581 | - | 601 | - | $5,580 | $3,353,581 | 1 | Buena Vista International | true | false |
| 3 | 2 | Casino Royale | $2,527,556 | +43.3% | 628 | -150 | $4,024 | $43,227,248 | 6 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Holiday | $2,028,014 | +22.1% | 545 | +5 | $3,721 | $8,903,835 | 3 | United International Pictures | false | false |
| 5 | 1 | Eragon | $1,740,433 | -9.8% | 788 | -10 | $2,208 | $10,225,477 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | The Departed | $865,250 | +6% | 418 | -15 | $2,069 | $7,531,604 | 4 | Warner Bros. | false | false |
| 7 | 5 | Happy Feet | $685,682 | +29.5% | 694 | -10 | $988 | $6,449,480 | 5 | Warner Bros. | false | false |
| 8 | 7 | Babel | $621,943 | +74.9% | 107 | - | $5,812 | $1,417,973 | 2 | TOBIS Film | false | false |
| 9 | 6 | Flushed Away | $536,453 | +17.8% | 623 | -66 | $861 | $4,021,405 | 4 | United International Pictures | false | false |
| 10 | 8 | Apocalypto | $234,066 | -1.8% | 280 | -2 | $835 | $1,427,551 | 3 | Constantin Film | false | false |
| 11 | 15 | Vitus | $219,228 | +96.8% | 71 | -1 | $3,087 | $494,684 | 2 | S&W Entertainment Limited | false | false |
| 12 | - | Grave Decisions | $177,172 | - | 60 | - | $2,952 | $9,987,123 | 20 | Movienet | false | false |
| 13 | - | Hoodwinked! | $177,043 | - | 365 | - | $485 | $305,055 | 1 | Kinowelt Filmverleih | true | false |
| 14 | 13 | The Ugly Duckling and Me! | $175,579 | +53.8% | 300 | +1 | $585 | $457,441 | 2 | Warner Bros. | false | false |
| 15 | - | Little Miss Sunshine | $151,426 | - | 55 | - | $2,753 | $1,600,374 | 5 | 20th Century Fox International | false | false |
