| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Apocalypto | $373,037 | - | 81 | - | $4,605 | $373,037 | 1 | A-Film Distribution | true | false |
| 2 | 2 | Casino Royale | $343,624 | -54.5% | 122 | -6 | $2,816 | $9,288,341 | 8 | Sony Pictures Releasing | false | false |
| 3 | 3 | Saw III | $311,542 | -52.5% | 61 | +1 | $5,107 | $1,172,489 | 2 | Independent Films | false | false |
| 4 | 4 | The Holiday | $294,893 | -54.1% | 96 | - | $3,071 | $3,812,858 | 5 | United International Pictures | false | false |
| 5 | 1 | Happy Feet | $238,690 | -79.4% | 169 | -2 | $1,412 | $6,249,144 | 6 | Warner Bros. | false | false |
| 6 | 7 | Deja Vu | $197,261 | -42.9% | 70 | -1 | $2,818 | $2,099,848 | 5 | Buena Vista International | false | false |
| 7 | 11 | Perfume: The Story of a Murderer | $117,177 | -35.6% | 50 | -2 | $2,343 | $1,310,198 | 6 | RCV Film Distribution | false | false |
| 8 | 5 | Crusade in Jeans | $101,718 | -74.9% | 97 | -34 | $1,048 | $1,973,967 | 9 | Benelux Film Distributors | false | false |
| 9 | 8 | Eragon | $95,977 | -69.9% | 97 | -16 | $989 | $1,973,967 | 5 | 20th Century Fox International | false | false |
| 10 | 12 | Happy Family | $77,577 | -54.2% | 58 | - | $1,337 | $908,594 | 5 | RCV Film Distribution | false | false |
| 11 | 13 | Black Book | $64,401 | -17.8% | 53 | +9 | $1,215 | $9,202,808 | 18 | A-Film Distribution | false | false |
| 12 | 6 | Charlotte's Web | $62,629 | -83.2% | 94 | -16 | $666 | $1,357,095 | 4 | United International Pictures | false | false |
| 13 | 15 | The Illusionist | $60,935 | -12.2% | 15 | - | $4,062 | $185,356 | 2 | Independent Films | false | false |
| 14 | 17 | The Queen | $50,536 | -23.2% | 23 | +2 | $2,197 | $665,321 | 7 | A-Film Distribution | false | false |
| 15 | 9 | Flushed Away | $50,521 | -80.7% | 109 | -1 | $463 | $1,547,109 | 7 | United International Pictures | false | false |
| 16 | 16 | Babel | $47,549 | -29.5% | 21 | - | $2,264 | $1,417,653 | 11 | Independent Films | false | false |
| 17 | 14 | The Departed | $37,569 | -48.1% | 21 | -7 | $1,789 | $2,342,010 | 10 | Warner Bros. | false | false |
| 18 | 10 | Plop in de stad | $36,838 | -82.1% | 101 | - | $364 | $777,086 | 5 | Independent Films | false | false |
| 19 | 18 | The Page Turner | $21,825 | -29.8% | 20 | +1 | $1,091 | $312,619 | 7 | Benelux Film Distributors | false | false |
| 20 | 19 | Borat | $11,043 | -45% | 11 | -1 | $1,003 | $3,110,885 | 11 | 20th Century Fox International | false | false |
