| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Pursuit of Happyness | $3,123,856 | - | 512 | - | $6,101 | $3,123,856 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Night at the Museum | $1,680,918 | -38.1% | 807 | -23 | $2,082 | $19,320,340 | 4 | 20th Century Fox International | false | false |
| 3 | 2 | My Führer | $1,292,470 | -49.5% | 389 | +124 | $3,322 | $4,401,050 | 2 | X Verleih AG | false | false |
| 4 | - | John Tucker Must Die | $1,255,574 | - | 402 | - | $3,123 | $1,255,574 | 1 | 20th Century Fox International | true | false |
| 5 | - | The Other Boy | $946,576 | - | 250 | - | $3,786 | $946,756 | 1 | Constantin Film | true | false |
| 6 | 3 | Deja Vu | $717,306 | -50.6% | 595 | -6 | $1,205 | $9,875,599 | 4 | Buena Vista International | false | false |
| 7 | 4 | The Holiday | $605,351 | -54% | 535 | -9 | $1,131 | $14,669,877 | 6 | United International Pictures | false | false |
| 8 | 5 | Casino Royale | $604,060 | -51.2% | 413 | -127 | $1,462 | $48,468,450 | 9 | Sony Pictures Releasing | false | false |
| 9 | 9 | Babel | $531,613 | -6.3% | 113 | -1 | $4,704 | $4,117,785 | 5 | TOBIS Film | false | false |
| 10 | 6 | The Queen | $483,707 | -33.9% | 153 | - | $3,161 | $1,462,674 | 2 | Concorde Filmverleih | false | false |
| 11 | 10 | Charlotte's Web | $389,568 | -25% | 398 | -2 | $978 | $2,147,206 | 3 | United International Pictures | false | false |
| 12 | 7 | The Departed | $309,085 | -48.7% | 336 | -79 | $919 | $10,030,352 | 7 | Warner Bros. | false | false |
| 13 | - | The Singer (Quand j'étais chanteur) | $271,140 | - | 59 | - | $4,595 | $271,140 | 1 | Prokino Filmverleih | true | false |
| 14 | 12 | Happy Feet | $200,929 | -30.2% | 496 | -101 | $405 | $7,939,951 | 8 | Warner Bros. | false | false |
| 15 | 8 | Eragon | $200,813 | -65.5% | 424 | -264 | $473 | $13,298,510 | 6 | 20th Century Fox International | false | false |
