| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Pursuit of Happyness | $312,180 | - | 28 | - | $11,149 | $331,655 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Blood Diamond | $301,616 | -26.8% | 51 | - | $5,914 | $1,328,439 | 3 | Warner Bros. | false | false |
| 3 | - | Charlotte's Web | $217,731 | - | 54 | - | $4,032 | $271,113 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 1 | Rocky Balboa | $206,435 | -51% | 50 | - | $4,128 | $796,461 | 2 | 20th Century Fox International | false | false |
| 5 | 3 | The Departed | $137,460 | -12.2% | 70 | -4 | $1,963 | $2,982,566 | 7 | Warner Bros. | false | false |
| 6 | - | Odette Toulemonde | $132,521 | - | 16 | - | $8,282 | $132,521 | 1 | Alternative Films | true | false |
| 7 | - | The Texas Chainsaw Massacre: The Beginning | $99,014 | - | 28 | - | $3,536 | $142,034 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 8 | 4 | John Tucker Must Die | $86,861 | -34.3% | 30 | - | $2,895 | $1,223,290 | 6 | 20th Century Fox International | false | false |
| 9 | 5 | The Illusionist | $85,883 | -32% | 17 | - | $5,051 | $424,719 | 3 | Belga Films | false | false |
| 10 | 9 | The Lives of Others | $82,615 | +7.2% | 18 | - | $4,589 | $187,424 | 2 | ABC Distribution | false | false |
| 11 | - | The Last King of Scotland | $74,054 | - | 15 | - | $4,936 | $75,446 | 1 | 20th Century Fox International | true | false |
| 12 | 8 | Happy Feet | $71,590 | -22.3% | 82 | -8 | $873 | $4,452,866 | 10 | Warner Bros. | false | false |
| 13 | 7 | Treasured Island | $63,104 | -36.7% | 19 | -6 | $3,321 | $177,488 | 2 | Victory Productions | false | false |
| 14 | 10 | Arthur and the Invisibles | $55,590 | -26% | 45 | - | $1,235 | $2,382,268 | 9 | United International Pictures | false | false |
| 15 | 11 | Babel | $51,120 | -26.3% | 31 | -3 | $1,649 | $2,205,730 | 13 | Belga Films | false | false |
| 16 | 6 | The Holiday | $49,086 | -53.4% | 46 | -9 | $1,067 | $2,759,483 | 8 | United International Pictures | false | false |
| 17 | 20 | The Prestige | $46,966 | +155.9% | 19 | +1 | $2,471 | $661,447 | 5 | Warner Bros. | false | false |
| 18 | - | Inland Empire | $37,919 | - | 11 | - | $3,447 | $39,552 | 1 | Cinéart | true | false |
| 19 | - | Ex Drummer | $37,501 | - | 11 | - | $3,409 | $87,573 | 2 | AF-Media | false | false |
| 20 | 14 | Deja Vu | $37,382 | -37.7% | 17 | -7 | $2,198 | $2,113,210 | 9 | Buena Vista International | false | false |
