| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $3,188,774 | -32.5% | 463 | -8 | $6,887 | $9,511,124 | 2 | 20th Century Fox International | false | false |
| 2 | - | Hannibal Rising | $2,859,156 | - | 365 | - | $7,833 | $2,859,156 | 1 | Filmauro | true | false |
| 3 | - | The Holiday | $1,988,456 | - | 316 | - | $6,292 | $1,988,456 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Manual of Love 2 | $1,185,663 | -55.9% | 27 | -467 | $43,913 | $23,400,827 | 4 | Filmauro | false | false |
| 5 | 4 | A Dinner for Them to Meet | $942,007 | -30.9% | 260 | -2 | $3,623 | $2,778,431 | 2 | Medusa Distribuzione | false | false |
| 6 | - | Arthur and the Invisibles | $929,878 | - | 345 | - | $2,695 | $929,878 | 1 | 01 Distribution | true | false |
| 7 | 3 | The Pursuit of Happyness | $727,059 | -53.6% | 198 | -141 | $3,672 | $18,986,163 | 5 | Medusa Distribuzione | false | false |
| 8 | 5 | Blood Diamond | $638,352 | -46.5% | 183 | -83 | $3,488 | $4,540,899 | 3 | Warner Bros. | false | false |
| 9 | 6 | Step Up | $522,467 | -55.6% | 177 | -61 | $2,951 | $4,371,142 | 3 | Medusa Distribuzione | false | false |
| 10 | - | Mi fido di te | $302,537 | - | 103 | - | $2,937 | $302,537 | 1 | Medusa Distribuzione | true | false |
| 11 | - | Breaking and Entering | $143,990 | - | 77 | - | $1,870 | $143,990 | 1 | Buena Vista International | true | false |
| 12 | 7 | Miss Potter | $129,540 | -44.1% | 54 | -92 | $2,398 | $462,757 | 2 | Eagle Pictures | false | false |
| 13 | 8 | Bobby | $118,280 | -46.5% | 33 | -43 | $3,584 | $1,618,217 | 4 | 01 Distribution | false | false |
| 14 | - | Inland Empire | $107,228 | - | 24 | - | $4,467 | $107,228 | 1 | BIM Distribuzione | true | false |
| 15 | - | The Page Turner | $72,326 | - | 16 | - | $4,520 | $72,326 | 1 | Mikado Film | true | false |
| 16 | 14 | The Science of Sleep | $61,437 | -22.9% | 26 | -9 | $2,362 | $686,372 | 4 | Mikado Film | false | false |
| 17 | 12 | Black Book | $50,205 | -62.9% | 34 | -35 | $1,476 | $245,925 | 2 | DNC Entertainment | false | false |
| 18 | 15 | The Boss of It All | $38,459 | -42.2% | 12 | -15 | $3,204 | $1,224,987 | 6 | Lucky Red | false | false |
| 19 | 10 | Stranger Than Fiction | $29,004 | -81.3% | 26 | -70 | $1,115 | $256,744 | 2 | Sony Pictures Releasing | false | false |
| 20 | 18 | Little Red Flowers | $27,700 | -24.7% | 15 | -1 | $1,846 | $295,370 | 5 | Istituto Luce | false | false |
