| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Music and Lyrics | $154,966 | - | 44 | - | $3,521 | $205,377 | 1 | Roadshow Films | true | false |
| 2 | 1 | The Pursuit of Happyness | $72,789 | -34.9% | 50 | - | $1,455 | $927,544 | 4 | Sony Pictures Releasing | false | false |
| 3 | - | The Good Shepherd | $65,320 | - | 29 | - | $2,252 | $65,320 | 1 | Paramount Pictures International | true | false |
| 4 | 2 | Blood Diamond | $60,214 | -32.5% | 40 | -2 | $1,505 | $855,416 | 5 | Warner Bros. | false | false |
| 5 | 3 | Epic Movie | $39,507 | -39.9% | 40 | - | $987 | $708,773 | 4 | 20th Century Fox International | false | false |
| 6 | 8 | The Queen | $31,559 | -17.6% | 51 | +33 | $618 | $1,455,978 | 9 | Icon Film Distribution | false | false |
| 7 | 9 | The History Boys | $30,970 | -13.6% | 10 | - | $3,097 | $208,410 | 4 | 20th Century Fox International | false | false |
| 8 | 4 | The Last King of Scotland | $30,810 | -33.4% | 20 | - | $1,540 | $104,849 | 2 | 20th Century Fox International | false | false |
| 9 | 7 | Casino Royale | $24,528 | -36.2% | 42 | -10 | $584 | $4,118,986 | 11 | Sony Pictures Releasing | false | false |
| 10 | 10 | Babel | $20,812 | -34.6% | 17 | - | $1,224 | $427,406 | 7 | United International Pictures | false | false |
| 11 | 5 | Rocky Balboa | $20,757 | -51.7% | 40 | - | $518 | $234,733 | 3 | 20th Century Fox International | false | false |
| 12 | 6 | Stranger Than Fiction | $20,043 | -52.6% | 20 | -1 | $1,002 | $168,461 | 3 | Roadshow Films | false | false |
| 13 | 12 | Apocalypto | $16,462 | -40.5% | 28 | -2 | $587 | $657,800 | 6 | Hoyts Distribution | false | false |
| 14 | 13 | Happy Feet | $16,149 | -41.1% | 70 | -1 | $230 | $2,955,540 | 8 | Roadshow Films | false | false |
| 15 | 11 | Dreamgirls | $13,111 | -54.9% | 26 | -7 | $504 | $450,638 | 5 | Paramount Pictures International | false | false |
| 16 | 15 | Open Season | $11,934 | -47.4% | 51 | -12 | $234 | $948,002 | 6 | Sony Pictures Releasing | false | false |
| 17 | 14 | A Prairie Home Companion | $11,888 | -52.3% | 24 | -3 | $495 | $90,013 | 3 | - | false | false |
| 18 | 18 | Little Miss Sunshine | $10,310 | -26.4% | 24 | - | $429 | $746,461 | 19 | 20th Century Fox International | false | false |
| 19 | 20 | The Valet | $9,555 | -11.6% | 18 | - | $530 | $463,167 | 9 | Rialto Distribution | false | false |
| 20 | - | Orchestra Seats | $9,410 | - | 7 | - | $1,344 | $9,410 | 1 | Rialto Distribution | true | false |
