| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Norbit | $201,905 | - | 45 | - | $4,486 | $201,905 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Music and Lyrics | $126,563 | -18.3% | 44 | - | $2,876 | $387,620 | 2 | Roadshow Films | false | false |
| 3 | - | Notes on a Scandal | $79,032 | - | 20 | - | $3,951 | $79,032 | 1 | 20th Century Fox International | true | false |
| 4 | - | Hannibal Rising | $53,191 | - | 27 | - | $1,970 | $53,191 | 1 | Roadshow Films | true | false |
| 5 | 2 | The Pursuit of Happyness | $49,420 | -32.1% | 48 | -2 | $1,029 | $976,573 | 5 | Sony Pictures Releasing | false | false |
| 6 | 4 | Blood Diamond | $48,067 | -20.2% | 39 | -1 | $1,232 | $902,655 | 6 | Warner Bros. | false | false |
| 7 | 3 | The Good Shepherd | $46,855 | -28.3% | 29 | - | $1,615 | $135,431 | 2 | Paramount Pictures International | false | false |
| 8 | 7 | The History Boys | $27,493 | -11.2% | 10 | - | $2,749 | $241,316 | 5 | 20th Century Fox International | false | false |
| 9 | 6 | The Queen | $25,009 | -20.8% | 15 | -36 | $1,667 | $1,455,002 | 10 | Icon Film Distribution | false | false |
| 10 | 8 | The Last King of Scotland | $22,414 | -27.3% | 20 | - | $1,120 | $137,301 | 3 | 20th Century Fox International | false | false |
| 11 | - | Letters from Iwo Jima | $19,901 | - | 7 | - | $2,843 | $19,901 | 1 | Warner Bros. | true | false |
| 12 | 10 | Babel | $16,792 | -19.3% | 16 | -1 | $1,049 | $440,855 | 8 | United International Pictures | false | false |
| 13 | 5 | Epic Movie | $16,159 | -59.1% | 34 | -6 | $475 | $712,689 | 5 | 20th Century Fox International | false | false |
| 14 | 9 | Casino Royale | $13,632 | -44.4% | 22 | -20 | $619 | $4,015,455 | 12 | Sony Pictures Releasing | false | false |
| 15 | 18 | Little Miss Sunshine | $12,155 | +17.9% | 27 | +3 | $450 | $741,483 | 20 | 20th Century Fox International | false | false |
| 16 | 20 | Orchestra Seats | $11,173 | +18.7% | 9 | +2 | $1,241 | $22,255 | 2 | Rialto Distribution | false | false |
| 17 | 14 | Happy Feet | $11,085 | -31.4% | 68 | -2 | $163 | $2,878,445 | 9 | Roadshow Films | false | false |
| 18 | 19 | The Valet | $10,600 | +10.9% | 14 | -4 | $757 | $461,999 | 10 | Rialto Distribution | false | false |
| 19 | 16 | Open Season | $9,103 | -23.7% | 46 | -5 | $197 | $928,795 | 7 | Sony Pictures Releasing | false | false |
| 20 | 13 | Apocalypto | $8,711 | -47.1% | 16 | -12 | $544 | $655,346 | 7 | Hoyts Distribution | false | false |
