| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Music and Lyrics | $494,240 | - | 95 | - | $5,202 | $636,782 | 1 | Warner Bros. | true | false |
| 2 | - | Hannibal Rising | $234,471 | - | 82 | - | $2,859 | $284,268 | 1 | Benelux Film Distributors | true | false |
| 3 | 1 | Night at the Museum | $190,587 | -60.5% | 101 | - | $1,887 | $2,572,586 | 4 | 20th Century Fox International | false | false |
| 4 | 7 | The Lives of Others | $139,112 | -14.5% | 22 | - | $6,323 | $375,566 | 2 | Cinemien | false | false |
| 5 | 4 | Blood Diamond | $120,253 | -38.8% | 74 | -5 | $1,625 | $2,815,389 | 7 | Warner Bros. | false | false |
| 6 | 3 | Dreamgirls | $98,353 | -57% | 41 | +1 | $2,398 | $843,333 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | - | La Vie En Rose | $69,944 | - | 29 | - | $2,411 | $76,556 | 1 | RCV Film Distribution | true | false |
| 8 | 5 | Kicks | $69,226 | -62.8% | 35 | - | $1,977 | $436,629 | 2 | Independent Films | false | false |
| 9 | 10 | The Departed | $61,729 | -41.5% | 50 | -3 | $1,234 | $2,740,212 | 18 | Warner Bros. | false | false |
| 10 | 2 | Ernst, Bobbie en de geslepen Onix | $60,287 | -80% | 107 | - | $563 | $1,558,573 | 4 | Independent Films | false | false |
| 11 | 8 | The Good Shepherd | $55,144 | -55.5% | 45 | -14 | $1,225 | $684,888 | 4 | Benelux Film Distributors | false | false |
| 12 | - | Freedom Writers | $54,169 | - | 20 | - | $2,708 | $56,668 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | 14 | The Last King of Scotland | $43,756 | -39.2% | 15 | - | $2,917 | $419,664 | 5 | 20th Century Fox International | false | false |
| 14 | 9 | The Pursuit of Happyness | $43,176 | -64.1% | 33 | - | $1,308 | $1,303,751 | 6 | Sony Pictures Releasing | false | false |
| 15 | 6 | Barnyard | $40,467 | -76.4% | 74 | - | $546 | $901,643 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 13 | The Prestige | $38,558 | -52.3% | 26 | -4 | $1,483 | $757,704 | 5 | Warner Bros. | false | false |
| 17 | 15 | The Queen | $37,602 | -45.6% | 26 | - | $1,446 | $1,324,256 | 15 | A-Film Distribution | false | false |
| 18 | 18 | Babel | $33,191 | -36.9% | 32 | -1 | $1,037 | $2,116,465 | 19 | Independent Films | false | false |
| 19 | 16 | Notes on a Scandal | $27,619 | -50% | 12 | - | $2,301 | $201,222 | 3 | 20th Century Fox International | false | false |
| 20 | 11 | Arthur and the Invisibles | $18,796 | -78.7% | 78 | -7 | $240 | $707,611 | 6 | Independent Films | false | false |
