| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | 300 | $201,721 | -24.9% | 72 | +8 | $2,801 | $3,430,674 | 4 | Warner Bros. | false | false |
| 2 | 2 | Meet the Robinsons | $161,553 | -15.2% | 108 | +9 | $1,495 | $1,499,484 | 4 | Buena Vista International | false | false |
| 3 | 3 | Perfect Stranger | $137,386 | -27.4% | 50 | - | $2,747 | $63,826 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | The Lives of Others | $124,353 | - | 21 | - | $5,921 | $124,353 | 1 | Alfa Films | true | false |
| 5 | - | Disturbia | $98,310 | - | 30 | - | $3,277 | $98,310 | 1 | United International Pictures | true | false |
| 6 | - | Happily N'Ever After | $80,181 | - | 33 | - | $2,429 | $80,181 | 1 | Distribution Company | true | false |
| 7 | 4 | Wild Hogs | $67,528 | -28.5% | 41 | +1 | $1,647 | $180,279 | 2 | Buena Vista International | false | false |
| 8 | - | Trust the Man | $59,923 | - | 21 | - | $2,853 | $59,923 | 1 | Pachamama Cine | true | false |
| 9 | - | Sunshine | $46,952 | - | 20 | - | $2,347 | $46,952 | 1 | 20th Century Fox International | true | false |
| 10 | 8 | The Number 23 | $43,988 | -10.2% | 27 | - | $1,629 | $581,539 | 5 | Distribution Company | false | false |
| 11 | 5 | Music and Lyrics | $43,576 | -22% | 30 | - | $1,452 | $728,709 | 6 | Warner Bros. | false | false |
| 12 | 6 | TMNT | $35,301 | -33.7% | 51 | +2 | $692 | $241,476 | 3 | Distribution Company | false | false |
| 13 | 7 | The Reaping | $30,734 | -38.3% | 28 | -5 | $1,097 | $216,540 | 3 | Warner Bros. | false | false |
| 14 | 9 | Shooter | $30,057 | -22.1% | 30 | - | $1,001 | $189,797 | 3 | United International Pictures | false | false |
| 15 | - | El amor y la ciudad | $27,940 | - | 16 | - | $1,746 | $27,940 | 1 | Primer Plano Film Group | true | false |
| 16 | 10 | Scoop | $22,005 | -19.7% | 17 | -6 | $1,294 | $350,151 | 5 | CDI Films | false | false |
| 17 | 11 | Arthur and the Invisibles | $16,764 | -29.9% | 39 | -4 | $429 | $102,965 | 3 | Alfa Films | false | false |
| 18 | 13 | Paris, I Love You | $14,997 | -23% | 15 | +1 | $999 | $263,566 | 6 | Impacto Cine | false | false |
| 19 | 14 | Epic Movie | $13,768 | -11.8% | 18 | -2 | $764 | $166,262 | 4 | 20th Century Fox International | false | false |
| 20 | 19 | The Wicker Man | $10,145 | +15.3% | 18 | -1 | $563 | $210,981 | 7 | Distribution Company | false | false |
| 21 | 12 | Who Says It's Easy? | $9,763 | -50.1% | 22 | -5 | $443 | $1,276,452 | 11 | Primer Plano Film Group | false | false |
| 22 | 16 | Apocalypto | $8,529 | -29.2% | 26 | - | $328 | $827,080 | 12 | 20th Century Fox International | false | false |
| 23 | 15 | The Queen | $8,320 | -42.9% | 18 | -3 | $462 | $816,354 | 9 | Distribution Company | false | false |
| 24 | 18 | Ghost Rider | $8,189 | -26.2% | 27 | -11 | $303 | $553,175 | 6 | Sony Pictures Releasing | false | false |
| 25 | 17 | Pathfinder | $6,406 | -46% | 11 | -3 | $582 | $145,651 | 5 | 20th Century Fox International | false | false |
| 26 | 21 | Letters from Iwo Jima | $6,404 | -4% | 12 | -1 | $533 | $300,886 | 10 | Warner Bros. | false | false |
| 27 | 46 | Stranger Than Fiction | $4,177 | +1,360.5% | 6 | +5 | $696 | $172,024 | 7 | Sony Pictures Releasing | false | false |
| 28 | 23 | Blood Diamond | $3,933 | -29.8% | 10 | -2 | $393 | $881,015 | 11 | Warner Bros. | false | false |
| 29 | 36 | Crank | $3,384 | +508.6% | 7 | +5 | $483 | $150,798 | 7 | Alfa Films | false | false |
| 30 | 29 | The Last King of Scotland | $2,726 | +4.1% | 10 | +2 | $272 | $158,449 | 10 | 20th Century Fox International | false | false |
| 31 | 20 | Norbit | $2,536 | -65% | 12 | -6 | $211 | $240,953 | 7 | United International Pictures | false | false |
| 32 | 24 | Rocky Balboa | $2,518 | -51.5% | 15 | -7 | $167 | $404,657 | 8 | 20th Century Fox International | false | false |
| 33 | 25 | Notes on a Scandal | $2,196 | -54% | 7 | -2 | $313 | $184,776 | 7 | 20th Century Fox International | false | false |
| 34 | 27 | Babel | $1,925 | -50.1% | 9 | -12 | $213 | $1,729,865 | 14 | United International Pictures | false | false |
| 35 | 22 | The Education of Fairies | $1,594 | -74.8% | 9 | -9 | $177 | $74,705 | 4 | Buena Vista International | false | false |
| 36 | 28 | Hoodwinked! | $1,203 | -68.4% | 10 | -11 | $120 | $808,756 | 11 | Alfa Films | false | false |
| 37 | - | Funny Ha Ha 2007 Re-release | $1,075 | - | 1 | - | $1,075 | $1,075 | 1 | 791 Cine | true | false |
| 38 | 37 | City in Heat | $1,038 | +98.1% | 3 | +1 | $346 | $31,107 | 5 | Alfa Films | false | false |
| 39 | 26 | Captain Alatriste: The Spanish Musketeer | $642 | -85.6% | 2 | -13 | $321 | $31,932 | 3 | 20th Century Fox International | false | false |
| 40 | 44 | Charlotte's Web | $480 | +62.7% | 5 | +2 | $96 | $298,671 | 13 | United International Pictures | false | false |
| 41 | 39 | See No Evil | $431 | -2% | 1 | - | $431 | $65,464 | 9 | Alfa Films | false | false |
| 42 | 35 | Flags of Our Fathers | $387 | -43.1% | 6 | - | $64 | $206,955 | 13 | Warner Bros. | false | false |
| 43 | 31 | Pan's Labyrinth | $375 | -72.3% | 2 | -3 | $187 | $187,916 | 16 | Warner Bros. | false | false |
| 44 | 43 | C.R.A.Z.Y. | $334 | -4% | 1 | -1 | $334 | $47,581 | 6 | Alfa Films | false | false |
| 45 | 41 | The Good Shepherd | $327 | -24.3% | 2 | - | $163 | $362,924 | 9 | United International Pictures | false | false |
| 46 | 45 | Happy Feet | $227 | -22.8% | 4 | +1 | $56 | $1,377,614 | 20 | Warner Bros. | false | false |
| 47 | 38 | Time to Leave | $161 | -65.1% | 1 | -1 | $161 | $61,209 | 8 | Alfa Films | false | false |
| 48 | 32 | Night at the Museum | $144 | -87.3% | 4 | -4 | $36 | $3,210,707 | 14 | 20th Century Fox International | false | false |
| 49 | 40 | The Departed | $100 | -76.9% | 1 | -1 | $100 | $2,011,780 | 23 | Warner Bros. | false | false |
| 50 | 30 | Pura sangre | $93 | -95.8% | 1 | -3 | $93 | $266,106 | 3 | Primer Plano Film Group | false | false |
| 51 | 47 | Flushed Away | $19 | -91% | 1 | -2 | $19 | $1,581,004 | 16 | United International Pictures | false | false |
