| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Spider-Man 3 | $4,372,391 | -60.5% | 425 | -333 | $10,287 | $16,893,309 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | I Could Never Be Your Woman | $584,949 | - | 173 | - | $3,381 | $584,949 | 1 | N/A | true | false |
| 3 | - | The Hills Have Eyes 2 | $558,008 | - | 249 | - | $2,240 | $558,008 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Premonition | $447,642 | -38% | 251 | -1 | $1,783 | $3,681,880 | 3 | DeAPlaneta | false | false |
| 5 | 3 | Music and Lyrics | $253,917 | -42.6% | 292 | -15 | $869 | $3,862,794 | 4 | Warner Bros. | false | false |
| 6 | 5 | The Number 23 | $209,841 | -38.7% | 243 | -37 | $863 | $3,447,454 | 4 | - | false | false |
| 7 | 6 | Perfect Stranger | $186,603 | -33.6% | 224 | -58 | $833 | $5,174,484 | 5 | Sony Pictures Releasing | false | false |
| 8 | 4 | Fur: An Imaginary Portrait of Diane Arbus | $183,249 | -50.3% | 151 | -4 | $1,213 | $619,110 | 2 | TriPictures | false | false |
| 9 | 7 | Curse of the Golden Flower | $160,826 | -38.7% | 99 | -1 | $1,624 | $1,462,900 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | Who Says It's Easy? | $119,857 | -49.4% | 81 | -1 | $1,479 | $414,730 | 2 | On Pictures | false | false |
| 11 | - | City in Heat | $113,064 | - | 66 | - | $1,713 | $113,064 | 1 | Alta Films | true | false |
| 12 | 11 | La Vie En Rose | $110,236 | -37.1% | 86 | -2 | $1,281 | $1,259,052 | 4 | Alta Films | false | false |
| 13 | - | Comedy of Power | $107,250 | - | 31 | - | $3,459 | $107,250 | 1 | Wanda Visión S.A. | true | false |
| 14 | 12 | The Good Shepherd | $107,129 | -29.4% | 98 | -10 | $1,093 | $4,184,880 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | Wild Hogs | $105,821 | -41% | 182 | -64 | $581 | $3,844,964 | 5 | Buena Vista International | false | false |
| 16 | 9 | Sunshine | $92,804 | -51.6% | 202 | -79 | $459 | $2,729,116 | 4 | 20th Century Fox International | false | false |
| 17 | 13 | The Lives of Others | $88,665 | -27.5% | 78 | -3 | $1,136 | $5,611,856 | 13 | Alta Films | false | false |
| 18 | 14 | Charlotte's Web | $78,769 | -32.4% | 107 | -7 | $736 | $860,636 | 3 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | 300 | $72,596 | -37% | 98 | -51 | $740 | $20,304,716 | 8 | Warner Bros. | false | false |
| 20 | 17 | Shooter | $67,810 | -36.1% | 80 | -57 | $847 | $2,637,021 | 5 | Universal Pictures International (UPI) | false | false |
| 21 | 67 | The Final Inquiry | $58 | -25.6% | 1 | -2 | $58 | $182,848 | 6 | Sony Pictures Releasing | false | false |
| 22 | 61 | The Pursuit of Happyness | $30 | -94.9% | 1 | -2 | $30 | $8,791,433 | 15 | Sony Pictures Releasing | false | false |
