| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: At World's End | $1,182,571 | -38.9% | 181 | +1 | $6,533 | $8,710,155 | 3 | Buena Vista International | false | false |
| 2 | - | Premonition | $124,948 | - | 38 | - | $3,288 | $189,599 | 1 | RCV Film Distribution | true | false |
| 3 | - | Death Proof | $95,892 | - | 30 | - | $3,196 | $95,892 | 1 | A-Film Distribution | true | false |
| 4 | 3 | Fracture | $75,162 | -27.7% | 51 | - | $1,473 | $872,301 | 4 | RCV Film Distribution | false | false |
| 5 | 4 | Zodiac | $66,985 | -20.3% | 19 | - | $3,525 | $182,836 | 2 | Warner Bros. | false | false |
| 6 | 2 | Spider-Man 3 | $63,330 | -41.8% | 95 | -8 | $666 | $4,079,205 | 6 | Sony Pictures Releasing | false | false |
| 7 | 5 | Mr. Bean's Holiday | $59,294 | -23.9% | 99 | -1 | $598 | $6,265,247 | 11 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | The Messengers | $46,016 | -27.3% | 20 | - | $2,300 | $150,353 | 2 | Benelux Film Distributors | false | false |
| 9 | 7 | The Reef | $40,539 | -15.2% | 85 | - | $476 | $643,233 | 4 | Independent Films | false | false |
| 10 | 10 | The Lives of Others | $32,767 | -14.1% | 31 | +2 | $1,057 | $1,818,143 | 15 | Cinemien | false | false |
| 11 | 9 | Next | $29,872 | -32.8% | 56 | -9 | $533 | $1,082,947 | 7 | RCV Film Distribution | false | false |
| 12 | 8 | The Number 23 | $28,795 | -35.7% | 22 | -2 | $1,308 | $421,734 | 4 | Paradiso Entertainment | false | false |
| 13 | 11 | Pan's Labyrinth | $21,705 | -25.6% | 21 | - | $1,033 | $567,968 | 7 | Paradiso Entertainment | false | false |
| 14 | 12 | The Reaping | $21,332 | -17.9% | 30 | -1 | $711 | $494,918 | 5 | Warner Bros. | false | false |
| 15 | - | Cashback | $15,684 | - | 13 | - | $1,206 | $36,967 | 1 | Moonlight Films | true | false |
| 16 | 16 | Happily N'Ever After | $12,997 | -2.1% | 66 | - | $196 | $405,310 | 7 | Independent Films | false | false |
| 17 | 13 | Perfect Stranger | $10,940 | -25.7% | 17 | -6 | $643 | $769,398 | 9 | Sony Pictures Releasing | false | false |
| 18 | 17 | Dark Blue Almost Black | $9,925 | -19.7% | 5 | - | $1,985 | $90,476 | 4 | A-Film Distribution | false | false |
| 19 | 14 | The Hoax | $8,356 | -43% | 15 | - | $557 | $97,953 | 3 | Independent Films | false | false |
| 20 | 15 | Wild Hogs | $7,896 | -41.5% | 22 | -18 | $358 | $1,333,102 | 9 | Buena Vista International | false | false |
| 21 | - | Jesus Camp | $2,083 | - | 2 | - | $1,041 | $2,083 | 1 | A-Film Distribution | true | false |
