| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Enchanted | $93,908 | -25.3% | 32 | -8 | $2,934 | $309,000 | 2 | Walt Disney Pictures | false | false |
| 2 | 1 | The Golden Compass | $89,168 | -42.6% | 39 | - | $2,286 | $331,145 | 2 | Warner Bros. | false | false |
| 3 | - | Alvin and the Chipmunks | $80,000 | - | 32 | - | $2,500 | $98,209 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | Bee Movie | $56,528 | -45.4% | 42 | - | $1,345 | $443,836 | 3 | United International Pictures | false | false |
| 5 | 5 | Saw IV | $22,752 | -43.8% | 26 | -1 | $875 | $188,357 | 3 | Walt Disney Pictures | false | false |
| 6 | 4 | Beowulf | $22,239 | -50.2% | 25 | -12 | $889 | $543,911 | 5 | Warner Bros. | false | false |
| 7 | 6 | Michael Clayton | $13,518 | -38.5% | 8 | -5 | $1,689 | $84,561 | 3 | Bazuca Films | false | false |
| 8 | - | The Heartbreak Kid | $12,694 | - | 28 | - | $453 | $12,694 | 1 | United International Pictures | true | false |
| 9 | 7 | Che Kopete: La película | $6,385 | -69.7% | 17 | -17 | $375 | $830,795 | 6 | - | false | false |
| 10 | 8 | Resident Evil: Extinction | $4,131 | -50.8% | 10 | - | $413 | $381,233 | 8 | Sony Pictures Releasing | false | false |
| 11 | 9 | Knocked Up | $4,010 | -45.7% | 3 | -4 | $1,336 | $124,196 | 6 | United International Pictures | false | false |
| 12 | 11 | Lions for Lambs | $3,363 | -42.6% | 6 | -1 | $560 | $1,377,354 | 6 | 20th Century Fox International | false | false |
| 13 | 12 | I Now Pronounce You Chuck & Larry | $1,667 | -61.9% | 6 | -1 | $277 | $103,050 | 5 | United International Pictures | false | false |
| 14 | 15 | Inland Empire | $1,641 | +2.7% | 1 | - | $1,641 | $15,059 | 4 | N/A | false | false |
| 15 | 13 | Underdog | $922 | -76% | 9 | -7 | $102 | $465,204 | 9 | Walt Disney Pictures | false | false |
| 16 | 14 | Sicko | $653 | -74.5% | 1 | -2 | $653 | $4,399 | 2 | Transeuropa | false | false |
| 17 | 25 | Next | $637 | +405.6% | 1 | - | $637 | $107,328 | 7 | United International Pictures | false | false |
| 18 | 19 | Premonition | $339 | -69.8% | 1 | -1 | $339 | $258,777 | 11 | Bazuca Films | false | false |
| 19 | 18 | The Seeker: The Dark Is Rising | $288 | -75.7% | 1 | -3 | $288 | $200,218 | 8 | 20th Century Fox International | false | false |
| 20 | 22 | Saint Ange 2006 Re-release | $162 | -67% | 1 | - | $162 | $122,126 | 9 | Bazuca Films | false | false |
| 21 | 16 | The Bourne Ultimatum | $132 | -90.3% | 1 | -1 | $132 | $335,991 | 9 | United International Pictures | false | false |
