| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Natale in crociera | $4,448,843 | -19.6% | 581 | - | $7,657 | $12,010,731 | 2 | Filmauro | false | false |
| 2 | 2 | A Beautiful Wife | $3,241,895 | -21.6% | 494 | -19 | $6,562 | $8,940,546 | 2 | Medusa Distribuzione | false | false |
| 3 | - | National Treasure: Book of Secrets | $1,728,317 | - | 297 | - | $5,819 | $1,728,317 | 1 | Walt Disney Pictures | true | false |
| 4 | 3 | The Golden Compass | $1,547,193 | -26.7% | 376 | -3 | $4,114 | $4,352,118 | 2 | 01 Distribution | false | false |
| 5 | - | Bee Movie | $1,063,474 | - | 351 | - | $3,029 | $1,063,610 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | Lions for Lambs | $694,576 | - | 135 | - | $5,145 | $694,576 | 1 | 20th Century Fox International | true | false |
| 7 | - | Love in the Time of Cholera | $561,268 | - | 177 | - | $3,171 | $561,268 | 1 | 01 Distribution | true | false |
| 8 | 4 | Enchanted | $540,576 | -61.8% | 239 | -150 | $2,261 | $6,239,285 | 3 | Walt Disney Pictures | false | false |
| 9 | 5 | Eastern Promises | $435,951 | -28.1% | 153 | +7 | $2,849 | $1,311,350 | 2 | Eagle Pictures | false | false |
| 10 | 10 | Irina Palm | $133,535 | -15.6% | 46 | +6 | $2,902 | $626,032 | 3 | Teodora Film | false | false |
| 11 | 6 | Winx Club: The Secret of the Lost Kingdom | $87,435 | -79.6% | 127 | -109 | $688 | $6,216,127 | 4 | 01 Distribution | false | false |
| 12 | - | The Assassination of Jesse James by the Coward Robert Ford | $78,069 | - | 77 | - | $1,013 | $78,069 | 1 | Warner Bros. | true | false |
| 13 | - | Caramel | $61,719 | - | 15 | - | $4,114 | $61,719 | 1 | Archibald | true | false |
| 14 | 9 | In the Valley of Elah | $61,419 | -67.7% | 26 | -59 | $2,362 | $1,885,378 | 4 | Mikado Film | false | false |
| 15 | 15 | Days of Darkness | $58,536 | -38.2% | 36 | - | $1,626 | $375,715 | 3 | BIM Distribuzione | false | false |
| 16 | 12 | Paranoid Park | $51,213 | -61.9% | 27 | -38 | $1,896 | $612,153 | 3 | Lucky Red | false | false |
| 17 | 17 | Across the Universe | $22,837 | -48.3% | 12 | -10 | $1,903 | $746,782 | 5 | Sony Pictures Releasing | false | false |
| 18 | 11 | Lezioni di cioccolato | $18,834 | -87.6% | 13 | -87 | $1,448 | $3,487,628 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 19 | Don't Waste Your Time, Johnny! | $14,334 | -53.5% | 6 | -15 | $2,389 | $393,565 | 4 | Medusa Distribuzione | false | false |
| 20 | 23 | Days and Clouds | $13,501 | -39.3% | 11 | -5 | $1,227 | $5,321,329 | 9 | Warner Bros. | false | false |
| 21 | 20 | Ratatouille | $13,141 | -52.1% | 17 | -13 | $773 | $25,033,728 | 10 | Walt Disney Pictures | false | false |
| 22 | 7 | Hitman | $7,563 | -97.6% | 4 | -181 | $1,890 | $1,902,198 | 3 | 20th Century Fox International | false | false |
| 23 | 21 | Conversations with My Gardener | $5,164 | -81.2% | 5 | -13 | $1,032 | $372,519 | 5 | BIM Distribuzione | false | false |
| 24 | 16 | August Rush | $4,843 | -91.6% | 6 | -49 | $807 | $1,511,583 | 4 | Medusa Distribuzione | false | false |
| 25 | 24 | I Viceré | $3,923 | -81.3% | 3 | -9 | $1,307 | $2,262,266 | 7 | 01 Distribution | false | false |
| 26 | 14 | 1408 | $3,595 | -96.6% | 2 | -63 | $1,797 | $5,349,727 | 5 | Lucky Red | false | false |
| 27 | 27 | Come tu mi vuoi | $3,019 | -56.5% | 3 | -7 | $1,006 | $10,178,742 | 7 | Medusa Distribuzione | false | false |
| 28 | 35 | Elizabeth: The Golden Age | $2,624 | -44.7% | 3 | -1 | $874 | $6,405,233 | 9 | Universal Pictures International (UPI) | false | false |
| 29 | 44 | The Romance of Astrea and Celadon | $2,266 | +25.9% | 1 | -1 | $2,266 | $259,501 | 17 | BIM Distribuzione | false | false |
| 30 | 25 | The Edge of Heaven | $2,129 | -80.7% | 2 | -7 | $1,064 | $643,436 | 7 | BIM Distribuzione | false | false |
| 31 | 41 | The Wind Blows Round | $2,039 | -21.9% | 1 | - | $2,039 | $352,168 | 34 | Aranciafilm | false | false |
| 32 | 22 | Beowulf | $1,896 | -92.3% | 1 | -13 | $1,896 | $4,950,890 | 6 | Warner Bros. | false | false |
| 33 | - | Terapia Roosevelt | $1,531 | - | 1 | - | $1,531 | $205,673 | 30 | Independent Films | false | false |
| 34 | 33 | The Hideout | $1,149 | -80.5% | 2 | -4 | $574 | $1,569,094 | 6 | 01 Distribution | false | false |
| 35 | 31 | Jellyfish | $1,111 | -81.9% | 3 | -3 | $370 | $210,558 | 6 | Sacher Distribuzione | false | false |
| 36 | 8 | Matrimonio alle Bahamas | $1,026 | -99.6% | 1 | -152 | $1,026 | $14,099,429 | 6 | Medusa Distribuzione | false | false |
| 37 | 36 | Little Boy Red | $993 | -77.5% | 2 | -2 | $496 | $112,106 | 6 | N/A | false | false |
| 38 | - | XXY | $976 | - | 1 | - | $976 | $432,690 | 27 | Teodora Film | false | false |
| 39 | - | Civico zero | $946 | - | 1 | - | $946 | $29,445 | 5 | Istituto Luce | false | false |
| 40 | 47 | Welcome to the Roses 2007 Re-release | $805 | -33.6% | 1 | - | $805 | $348,168 | 10 | Moviemax | false | false |
| 41 | 13 | Milan Palermo - The Return | $773 | -99.4% | 1 | -107 | $773 | $5,687,348 | 5 | Walt Disney Pictures | false | false |
| 42 | 40 | The Ball | $725 | -77.7% | 2 | +1 | $362 | $306,304 | 39 | Independent Films | false | false |
| 43 | 43 | Factory Girl | $719 | -64.3% | 1 | -3 | $719 | $216,537 | 5 | Moviemax | false | false |
| 44 | 18 | The Heartbreak Kid | $680 | -98.1% | 1 | -25 | $680 | $8,422,223 | 7 | Universal Pictures International (UPI) | false | false |
| 45 | 34 | The Nightmare Before Christmas 2008 3D Release | $526 | -89% | 1 | -3 | $526 | $82,133 | 4 | Walt Disney Pictures | false | false |
| 46 | - | Open Season | $451 | - | 1 | - | $451 | $4,338,099 | 55 | Sony Pictures Releasing | false | false |
| 47 | 30 | Fracture | $323 | -95.1% | 1 | -5 | $323 | $3,351,435 | 8 | Eagle Pictures | false | false |
| 48 | - | Regular Lovers | $230 | - | 1 | - | $230 | $111,594 | 1 | Istituto Luce | true | false |
| 49 | - | A Mighty Heart | $227 | - | 1 | - | $227 | $43,758 | 6 | Universal Pictures International (UPI) | false | false |
| 50 | - | Una ballata bianca | $59 | - | 1 | - | $59 | $1,074 | 3 | Independent Films | false | false |
