| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Game Plan | $358,882 | - | 39 | - | $9,202 | $775,064 | 2 | N/A | false | false |
| 2 | - | National Treasure: Book of Secrets | $275,811 | - | 57 | - | $4,838 | $1,169,547 | 3 | N/A | false | false |
| 3 | - | Alvin and the Chipmunks | $214,184 | - | 44 | - | $4,867 | $804,300 | 3 | N/A | false | false |
| 4 | - | Enchanted | $199,710 | - | 57 | - | $3,503 | $2,098,199 | 5 | N/A | false | false |
| 5 | - | Aliens vs. Predator: Requiem | $192,706 | - | 38 | - | $5,071 | $502,582 | 2 | N/A | false | false |
| 6 | - | Puras joyitas | $138,951 | - | 28 | - | $4,962 | $732,791 | 4 | N/A | false | false |
| 7 | 1 | Bee Movie | $66,160 | -6.2% | 54 | -19 | $1,225 | $714,222 | 4 | N/A | false | false |
| 8 | - | Fred Claus | $61,521 | - | 39 | - | $1,577 | $708,529 | 4 | N/A | false | false |
| 9 | - | The Heartbreak Kid | $51,977 | - | 26 | - | $1,999 | $727,947 | 5 | N/A | false | false |
| 10 | - | The Last Mimzy | $32,439 | - | 12 | - | $2,703 | $32,439 | 1 | N/A | true | false |
| 11 | - | I Now Pronounce You Chuck & Larry | $29,578 | - | 29 | - | $1,019 | $338,502 | 4 | N/A | false | false |
| 12 | - | The Golden Compass | $25,813 | - | 21 | - | $1,229 | $385,249 | 5 | N/A | false | false |
| 13 | - | Hairspray | $15,764 | - | 9 | - | $1,751 | $77,610 | 3 | N/A | false | false |
| 14 | - | The Lives of Others | $7,947 | - | 2 | - | $3,973 | $69,826 | 7 | N/A | false | false |
| 15 | - | The Darjeeling Limited | $5,742 | - | 1 | - | $5,742 | $11,302 | 2 | N/A | false | false |
| 16 | - | Ni tan largos... ni tan cortos | $4,435 | - | 2 | - | $2,217 | $359,267 | 9 | N/A | false | false |
| 17 | - | Knocked Up | $1,868 | - | 4 | - | $467 | $456,281 | 8 | N/A | false | false |
| 18 | - | Bratz | $1,028 | - | 8 | - | $128 | $45,151 | 4 | N/A | false | false |
| 19 | - | Beowulf | $171 | - | 1 | - | $171 | $744,764 | 7 | N/A | false | false |
