| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | National Treasure: Book of Secrets | $198,861 | - | 34 | - | $5,848 | $198,861 | 1 | N/A | true | false |
| 2 | - | I Am Legend | $132,635 | - | 35 | - | $3,789 | $528,839 | 2 | N/A | false | false |
| 3 | - | Alvin and the Chipmunks | $99,269 | - | 35 | - | $2,836 | $477,967 | 2 | N/A | false | false |
| 4 | - | The Game Plan | $53,027 | - | 34 | - | $1,559 | $494,476 | 3 | N/A | false | false |
| 5 | - | Aliens vs. Predator: Requiem | $33,679 | - | 35 | - | $962 | $562,357 | 3 | N/A | false | false |
| 6 | - | Enchanted | $24,628 | - | 34 | - | $724 | $735,478 | 6 | N/A | false | false |
| 7 | - | Alpha Dog | $24,028 | - | 13 | - | $1,848 | $24,028 | 1 | N/A | true | false |
| 8 | - | Black Book | $8,810 | - | 8 | - | $1,101 | $71,651 | 3 | N/A | false | false |
| 9 | - | Fred Claus | $5,754 | - | 15 | - | $383 | $154,154 | 5 | N/A | false | false |
| 10 | - | El cantante | $5,112 | - | 25 | - | $204 | $142,407 | 3 | N/A | false | false |
| 11 | - | The Painted Veil | $5,066 | - | 8 | - | $633 | $46,738 | 4 | N/A | false | false |
| 12 | - | Bee Movie | $3,638 | - | 43 | - | $84 | $418,578 | 5 | N/A | false | false |
| 13 | - | 1408 | $1,560 | - | 20 | - | $78 | $160,685 | 4 | N/A | false | false |
| 14 | - | Beowulf | $1,049 | - | 41 | - | $25 | $160,685 | 8 | N/A | false | false |
| 15 | - | The Golden Compass | $51 | - | 47 | - | $1 | $439,681 | 6 | N/A | false | false |
