| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Game Plan | $283,944 | -20.9% | 39 | - | $7,280 | $1,240,547 | 3 | N/A | false | false |
| 2 | - | The Orphanage | $175,654 | - | 41 | - | $4,284 | $212,632 | 1 | N/A | true | false |
| 3 | 2 | National Treasure: Book of Secrets | $160,388 | -41.8% | 56 | -1 | $2,864 | $1,484,991 | 4 | N/A | false | false |
| 4 | - | Good Luck Chuck | $123,397 | - | 25 | - | $4,935 | $123,397 | 1 | N/A | true | false |
| 5 | 3 | Alvin and the Chipmunks | $112,695 | -47.4% | 42 | -2 | $2,683 | $1,003,188 | 4 | N/A | false | false |
| 6 | 5 | Aliens vs. Predator: Requiem | $96,728 | -49.8% | 36 | -2 | $2,686 | $716,851 | 3 | N/A | false | false |
| 7 | 6 | Puras joyitas | $94,990 | -31.6% | 29 | +1 | $3,275 | $931,236 | 5 | N/A | false | false |
| 8 | 4 | Enchanted | $88,256 | -55.8% | 52 | -5 | $1,697 | $2,284,908 | 6 | N/A | false | false |
| 9 | - | Lions for Lambs | $83,312 | - | 30 | - | $2,777 | $83,312 | 1 | N/A | true | false |
| 10 | 7 | Bee Movie | $25,291 | -61.8% | 40 | -14 | $632 | $764,346 | 5 | N/A | false | false |
| 11 | 9 | The Heartbreak Kid | $25,246 | -51.4% | 19 | -7 | $1,328 | $789,722 | 6 | N/A | false | false |
| 12 | - | The Assassination of Jesse James by the Coward Robert Ford | $20,360 | - | 10 | - | $2,036 | $21,758 | 1 | N/A | true | false |
| 13 | 11 | I Now Pronounce You Chuck & Larry | $14,469 | -51.1% | 16 | -13 | $904 | $370,613 | 5 | N/A | false | false |
| 14 | 12 | The Golden Compass | $9,684 | -62.5% | 19 | -2 | $509 | $412,763 | 6 | N/A | false | false |
| 15 | 14 | The Lives of Others | $6,571 | -17.3% | 2 | - | $3,285 | $80,421 | 8 | N/A | false | false |
| 16 | 10 | The Last Mimzy | $6,405 | -80.3% | 11 | -1 | $582 | $51,367 | 2 | N/A | false | false |
| 17 | 8 | Fred Claus | $5,913 | -90.4% | 14 | -25 | $422 | $742,531 | 5 | N/A | false | false |
| 18 | 15 | The Darjeeling Limited | $5,463 | -4.9% | 1 | - | $5,463 | $20,523 | 3 | N/A | false | false |
| 19 | 13 | Hairspray | $3,445 | -78.1% | 3 | -6 | $1,148 | $87,407 | 4 | N/A | false | false |
| 20 | - | The 11th Hour | $2,081 | - | 2 | - | $1,040 | $2,081 | 1 | N/A | true | false |
| 21 | 19 | Beowulf | $2,015 | +1,078.4% | 1 | - | $2,015 | $747,257 | 8 | N/A | false | false |
| 22 | 16 | Ni tan largos... ni tan cortos | $1,865 | -57.9% | 2 | - | $932 | $363,244 | 10 | N/A | false | false |
