| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | National Treasure: Book of Secrets | $119,231 | -40% | 34 | - | $3,506 | $411,086 | 2 | N/A | false | false |
| 2 | 2 | I Am Legend | $75,612 | -43% | 35 | - | $2,160 | $670,550 | 3 | N/A | false | false |
| 3 | 3 | Alvin and the Chipmunks | $71,026 | -28.5% | 35 | - | $2,029 | $599,173 | 3 | N/A | false | false |
| 4 | - | Good Luck Chuck | $65,354 | - | 24 | - | $2,723 | $65,354 | 1 | N/A | true | false |
| 5 | - | Bridge to Terabithia | $49,588 | - | 16 | - | $3,099 | $49,588 | 1 | N/A | true | false |
| 6 | - | The Abandoned | $37,701 | - | 12 | - | $3,141 | $37,701 | 1 | N/A | true | false |
| 7 | 4 | The Game Plan | $37,533 | -29.2% | 34 | - | $1,103 | $560,660 | 4 | N/A | false | false |
| 8 | 7 | Alpha Dog | $8,989 | -62.6% | 13 | - | $691 | $48,227 | 2 | N/A | false | false |
| 9 | 6 | Enchanted | $8,764 | -64.4% | 34 | - | $257 | $757,305 | 7 | N/A | false | false |
| 10 | 5 | Aliens vs. Predator: Requiem | $7,105 | -78.9% | 35 | - | $203 | $589,379 | 4 | N/A | false | false |
| 11 | - | Whisper | $6,861 | - | 19 | - | $361 | $193,449 | 9 | N/A | false | false |
| 12 | 11 | The Painted Veil | $6,365 | +25.6% | 8 | - | $795 | $55,932 | 5 | N/A | false | false |
| 13 | 10 | El cantante | $5,352 | +4.7% | 25 | - | $214 | $153,759 | 4 | N/A | false | false |
| 14 | 8 | Black Book | $4,302 | -51.2% | 8 | - | $537 | $80,565 | 4 | N/A | false | false |
| 15 | 12 | Bee Movie | $2,197 | -39.6% | 43 | - | $51 | $422,103 | 6 | N/A | false | false |
| 16 | - | I Now Pronounce You Chuck & Larry | $1,645 | - | 32 | - | $51 | $221,397 | 9 | N/A | false | false |
| 17 | 9 | Fred Claus | $1,359 | -76.4% | 15 | - | $90 | $158,361 | 6 | N/A | false | false |
| 18 | - | Superbad | $1,247 | - | 1 | - | $1,247 | $156,897 | 8 | N/A | false | false |
