| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | I Am Legend | $491,146 | - | 81 | - | $6,063 | $491,146 | 1 | N/A | true | false |
| 2 | 1 | The Game Plan | $211,741 | -25.4% | 40 | +1 | $5,293 | $1,603,316 | 4 | N/A | false | false |
| 3 | 2 | The Orphanage | $139,435 | -20.6% | 41 | - | $3,400 | $490,854 | 2 | N/A | false | false |
| 4 | 4 | Good Luck Chuck | $87,061 | -29.4% | 26 | +1 | $3,348 | $296,225 | 2 | N/A | false | false |
| 5 | 3 | National Treasure: Book of Secrets | $85,802 | -46.5% | 55 | -1 | $1,560 | $1,663,606 | 5 | N/A | false | false |
| 6 | 5 | Alvin and the Chipmunks | $70,627 | -37.3% | 42 | - | $1,681 | $1,131,070 | 5 | N/A | false | false |
| 7 | 7 | Puras joyitas | $68,464 | -27.9% | 29 | - | $2,360 | $1,077,019 | 6 | N/A | false | false |
| 8 | 8 | Enchanted | $38,447 | -56.4% | 45 | -7 | $854 | $2,371,854 | 7 | N/A | false | false |
| 9 | 9 | Lions for Lambs | $36,811 | -55.8% | 18 | -12 | $2,045 | $164,627 | 2 | N/A | false | false |
| 10 | 6 | Aliens vs. Predator: Requiem | $29,593 | -69.4% | 26 | -10 | $1,138 | $815,133 | 4 | N/A | false | false |
| 11 | - | Prey | $26,567 | - | 11 | - | $2,415 | $26,567 | 1 | N/A | true | false |
| 12 | 10 | Bee Movie | $12,596 | -50.2% | 32 | -8 | $393 | $788,474 | 6 | N/A | false | false |
| 13 | 11 | The Heartbreak Kid | $7,234 | -71.3% | 12 | -7 | $602 | $818,422 | 7 | N/A | false | false |
| 14 | 19 | Hairspray | $6,961 | +102.1% | 7 | +4 | $994 | $97,207 | 5 | N/A | false | false |
| 15 | 15 | The Lives of Others | $5,884 | -10.5% | 2 | - | $2,942 | $89,286 | 9 | N/A | false | false |
| 16 | 12 | The Assassination of Jesse James by the Coward Robert Ford | $4,849 | -76.2% | 7 | -3 | $692 | $39,368 | 2 | N/A | false | false |
| 17 | 18 | The Darjeeling Limited | $4,326 | -20.8% | 1 | - | $4,326 | $27,951 | 4 | N/A | false | false |
| 18 | 13 | I Now Pronounce You Chuck & Larry | $4,010 | -72.3% | 9 | -7 | $445 | $387,591 | 6 | N/A | false | false |
| 19 | 14 | The Golden Compass | $3,524 | -63.6% | 14 | -5 | $251 | $430,814 | 7 | N/A | false | false |
| 20 | 16 | The Last Mimzy | $3,214 | -49.8% | 9 | -2 | $357 | $56,470 | 3 | N/A | false | false |
