| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | National Treasure: Book of Secrets | $288,304 | -31.8% | 71 | -19 | $4,060 | $917,049 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Charlie Wilson's War | $246,381 | - | 40 | - | $6,159 | $246,381 | 1 | United International Pictures | true | false |
| 3 | 2 | Enchanted | $231,861 | -16.7% | 87 | -6 | $2,665 | $2,114,540 | 4 | Walt Disney Pictures | false | false |
| 4 | 3 | I Am Legend | $159,873 | -24.2% | 79 | - | $2,023 | $1,812,012 | 5 | Warner Bros. | false | false |
| 5 | 5 | Aliens vs. Predator: Requiem | $87,021 | -5.7% | 36 | -4 | $2,417 | $452,956 | 3 | 20th Century Fox International | false | false |
| 6 | - | 1408 | $84,420 | - | 32 | - | $2,638 | $84,420 | 1 | United International Pictures | true | false |
| 7 | 4 | Love in the Time of Cholera | $69,336 | -32.7% | 30 | -3 | $2,311 | $221,945 | 2 | 20th Century Fox International | false | false |
| 8 | 7 | Alvin and the Chipmunks | $68,922 | +1.1% | 54 | -8 | $1,276 | $534,392 | 4 | 20th Century Fox International | false | false |
| 9 | 6 | American Gangster | $60,051 | -32.6% | 52 | -2 | $1,154 | $634,897 | 4 | United International Pictures | false | false |
| 10 | - | Hitman | $54,623 | - | 25 | - | $2,184 | $54,623 | 1 | 20th Century Fox International | true | false |
| 11 | 11 | The Heartbreak Kid | $31,046 | +11% | 28 | -1 | $1,108 | $837,667 | 12 | United International Pictures | false | false |
| 12 | 8 | The Golden Compass | $27,827 | -39.7% | 48 | -32 | $579 | $1,326,928 | 7 | Distribution Company | false | false |
| 13 | - | I Do: How to Get Married and Stay Single | $22,354 | - | 7 | - | $3,193 | $22,354 | 1 | Alfa Films | true | false |
| 14 | 9 | I Could Never Be Your Woman | $19,635 | -45.8% | 18 | -11 | $1,090 | $263,952 | 4 | CDI Films | false | false |
| 15 | 17 | Gone Baby Gone | $19,110 | +101.9% | 14 | +5 | $1,365 | $364,067 | 10 | Walt Disney Pictures | false | false |
| 16 | 12 | Sleuth | $15,711 | -43.3% | 10 | -1 | $1,571 | $119,810 | 3 | Sony Pictures Releasing | false | false |
| 17 | 10 | Giants of Valdes | $12,992 | -60.2% | 16 | -17 | $812 | $60,645 | 2 | Primer Plano Film Group | false | false |
| 18 | 13 | Bordertown | $11,460 | -57.3% | 22 | -10 | $520 | $50,120 | 2 | Distribution Company | false | false |
| 19 | 16 | My Best Friend | $7,710 | -37.5% | 7 | -3 | $1,101 | $102,201 | 4 | Alfa Films | false | false |
| 20 | 19 | 4 Months, 3 Weeks and 2 Days | $6,947 | +51.4% | 12 | +6 | $578 | $188,718 | 8 | Pachamama Cine | false | false |
| 21 | 15 | Bee Movie | $5,745 | -53.6% | 21 | -20 | $273 | $1,455,063 | 8 | United International Pictures | false | false |
| 22 | - | Goya's Ghosts | $5,537 | - | 4 | - | $1,384 | $5,537 | 1 | Alfa Films | true | false |
| 23 | 22 | Beowulf | $2,516 | -19.3% | 12 | -9 | $209 | $832,492 | 10 | Warner Bros. | false | false |
| 24 | 31 | The Assassination of Jesse James by the Coward Robert Ford | $2,379 | +158% | 8 | - | $297 | $146,833 | 9 | Warner Bros. | false | false |
| 25 | 21 | Café Lumière 2007 Re-release | $1,971 | -40% | 2 | - | $985 | $44,597 | 7 | 791 Cine | false | false |
| 26 | 18 | August Rush | $1,902 | -68.4% | 5 | -7 | $380 | $67,455 | 3 | Distribution Company | false | false |
| 27 | 14 | Bridge to Terabithia | $1,780 | -86% | 7 | -23 | $254 | $90,328 | 3 | United International Pictures | false | false |
| 28 | 23 | The Hitcher | $1,682 | -41.3% | 5 | -1 | $336 | $134,748 | 8 | Distribution Company | false | false |
| 29 | 32 | Lions for Lambs | $1,627 | +80.6% | 6 | -3 | $271 | $500,379 | 11 | 20th Century Fox International | false | false |
| 30 | 35 | Superbad | $1,417 | +193.4% | 10 | +4 | $141 | $389,338 | 10 | Sony Pictures Releasing | false | false |
| 31 | 30 | Open Season | $1,131 | +21% | 1 | - | $1,131 | $545,537 | 69 | Sony Pictures Releasing | false | false |
| 32 | 20 | The Flock | $1,085 | -74.3% | 6 | -9 | $180 | $183,459 | 8 | CDI Films | false | false |
| 33 | 24 | Retribution | $1,054 | -57.4% | 3 | -1 | $351 | $112,539 | 7 | Pachamama Cine | false | false |
| 34 | 27 | After the Wedding | $526 | -64.2% | 2 | -1 | $263 | $103,639 | 10 | Alfa Films | false | false |
| 35 | 36 | Whisper | $459 | +37.4% | 2 | +1 | $229 | $109,620 | 9 | Alfa Films | false | false |
| 36 | 48 | Underdog | $427 | +427.2% | 5 | +3 | $85 | $838,091 | 17 | Walt Disney Pictures | false | false |
| 37 | - | La señal | $362 | - | 3 | - | $120 | $1,096,646 | 20 | Walt Disney Pictures | false | false |
| 38 | 26 | Days of Glory | $339 | -79.8% | 2 | -1 | $169 | $18,222 | 4 | Alfa Films | false | false |
| 39 | 29 | Saw IV | $323 | -67.6% | 2 | -2 | $161 | $995,886 | 13 | Walt Disney Pictures | false | false |
| 40 | 28 | Hechos, No Palabras | $203 | -83% | 1 | - | $203 | $2,352 | 3 | Primer Plano Film Group | false | false |
| 41 | - | ¿De quién es el portaligas? | $160 | - | 2 | - | $80 | $85,560 | 19 | Primer Plano Film Group | false | false |
| 42 | - | City in Heat | $140 | - | 3 | - | $46 | $32,202 | 45 | Alfa Films | false | false |
| 43 | 43 | Michael Clayton | $138 | -33.7% | 1 | - | $138 | $551,193 | 16 | Alfa Films | false | false |
| 44 | - | The Aerial | $137 | - | 2 | - | $68 | $16,831 | 41 | Pachamama Cine | false | false |
| 45 | - | Who Says It's Easy? | $129 | - | 2 | - | $64 | $1,248,127 | 51 | Primer Plano Film Group | false | false |
| 46 | - | Rendition | $128 | - | 1 | - | $128 | $415,857 | 13 | Distribution Company | false | false |
| 47 | 39 | Lights in the Dusk | $124 | -47% | 1 | - | $124 | $50,663 | 18 | Alfa Films | false | false |
| 48 | - | A Stray Girlfriend | $114 | - | 2 | - | $57 | $47,582 | 34 | Primer Plano Film Group | false | false |
| 49 | - | The Other | $98 | - | 1 | - | $98 | $116,309 | 38 | Distribution Company | false | false |
| 50 | 41 | 12:08 East of Bucharest | $98 | -56.8% | 1 | - | $98 | $86,363 | 39 | Zeta Films | false | false |
| 51 | - | Kept and Dreamless | $95 | - | 2 | - | $47 | $18,616 | 40 | Primer Plano Film Group | false | false |
| 52 | 34 | Shortbus | $90 | -85.1% | 1 | -1 | $90 | $29,428 | 13 | Distribution Company | false | false |
| 53 | - | The Bow | $89 | - | 1 | - | $89 | $918,194 | 53 | Alfa Films | false | false |
| 54 | 47 | Fierro | $83 | - | 3 | +1 | $27 | $152,955 | 12 | Primer Plano Film Group | false | false |
| 55 | 45 | The Death of Mr. Lazarescu | $73 | -46.7% | 1 | - | $73 | $22,819 | 56 | Zeta Films | false | false |
| 56 | 42 | Encarnacion | $72 | -66.8% | 2 | - | $36 | $39,839 | 16 | Distribution Company | false | false |
| 57 | 51 | Black Book | $56 | +21.7% | 1 | - | $56 | $464,556 | 23 | Pachamama Cine | false | false |
| 58 | - | Incorregibles | $55 | - | 2 | - | $27 | $2,307,024 | 30 | Argentina Sono Film S.A.C.I. | false | false |
| 59 | - | Argentina latente | $50 | - | 1 | - | $50 | $32,631 | 36 | Primer Plano Film Group | false | false |
| 60 | 53 | Vitus | $45 | +18.4% | 1 | - | $45 | $47,663 | 11 | CDI Films | false | false |
| 61 | - | M | $41 | - | 2 | - | $20 | $5,279 | 22 | 791 Cine | false | false |
| 62 | 40 | Shattered | $39 | -83.2% | 1 | -3 | $39 | $320,874 | 12 | Distribution Company | false | false |
| 63 | - | Isidoro, la película | $33 | - | 2 | - | $16 | $678,736 | 30 | Pachamama Cine | false | false |
| 64 | - | Música nocturna | $32 | - | 1 | - | $32 | $25,238 | 11 | Primer Plano Film Group | false | false |
| 65 | - | When She Jumped | $29 | - | 1 | - | $29 | $6,541 | 13 | Primer Plano Film Group | false | false |
| 66 | - | Hacer patria | $21 | - | 1 | - | $21 | $8,858 | 25 | Distribution Company | false | false |
| 67 | - | Fotografías | $16 | - | 1 | - | $16 | $5,004 | 33 | Primer Plano Film Group | false | false |
| 68 | 38 | Sicko | $11 | -95.8% | 1 | - | $11 | $66,785 | 19 | Alfa Films | false | false |
| 69 | - | Pulqui, un instante en la patria de la felicidad | $7 | - | 1 | - | $7 | $1,683 | 29 | Primer Plano Film Group | false | false |
