| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | I Am Legend | $154,075 | -50.7% | 38 | - | $4,054 | $603,604 | 2 | Warner Bros. | false | false |
| 2 | - | Aliens vs. Predator: Requiem | $101,554 | - | 33 | - | $3,077 | $101,554 | 1 | 20th Century Fox International | true | false |
| 3 | 3 | The Game Plan | $80,093 | +3.7% | 21 | - | $3,813 | $209,412 | 2 | Walt Disney Pictures | false | false |
| 4 | 2 | Enchanted | $60,203 | -22.9% | 35 | +3 | $1,720 | $1,080,587 | 7 | Walt Disney Pictures | false | false |
| 5 | 4 | National Treasure: Book of Secrets | $54,825 | -21.7% | 40 | +4 | $1,370 | $773,646 | 5 | Walt Disney Pictures | false | false |
| 6 | 5 | Love in the Time of Cholera | $49,194 | -28.8% | 27 | - | $1,822 | $156,582 | 2 | 20th Century Fox International | false | false |
| 7 | 6 | Alvin and the Chipmunks | $35,218 | -34.7% | 31 | -1 | $1,136 | $645,058 | 6 | 20th Century Fox International | false | false |
| 8 | 9 | The Heartbreak Kid | $10,439 | -37.9% | 8 | -4 | $1,304 | $410,856 | 6 | United International Pictures | false | false |
| 9 | - | Lonely Hearts | $9,876 | - | 8 | - | $1,234 | $9,876 | 1 | Bazuca Films | true | false |
| 10 | - | Gone Baby Gone | $9,713 | - | 4 | - | $2,428 | $10,328 | 1 | Walt Disney Pictures | true | false |
| 11 | 8 | The Golden Compass | $9,081 | -58.5% | 11 | -6 | $825 | $736,062 | 7 | Warner Bros. | false | false |
| 12 | - | Private Fears in Public Places | $8,163 | - | 5 | - | $1,632 | $8,163 | 1 | Four Films | true | false |
| 13 | 10 | 30 Days of Night | $8,039 | -46.6% | 10 | -6 | $803 | $83,834 | 3 | Sony Pictures Releasing | false | false |
| 14 | - | Lie with Me | $6,691 | - | 10 | - | $669 | $6,691 | 1 | - | true | false |
| 15 | 7 | Chile puede | $6,248 | -79% | 8 | -24 | $781 | $319,781 | 4 | Warner Bros. | false | false |
| 16 | 17 | 1408 | $6,067 | +5.1% | 8 | +3 | $758 | $149,073 | 5 | United International Pictures | false | false |
| 17 | 15 | Beowulf | $5,633 | -15.4% | 2 | -1 | $2,816 | $612,753 | 10 | Warner Bros. | false | false |
| 18 | 19 | Michael Clayton | $5,408 | +25.7% | 2 | - | $2,704 | $144,271 | 8 | Bazuca Films | false | false |
| 19 | 20 | Sleuth | $3,250 | -16.4% | 1 | - | $3,250 | $15,785 | 3 | Sony Pictures Releasing | false | false |
| 20 | 12 | Venus | $3,117 | -74.5% | 6 | - | $519 | $19,488 | 2 | Transeuropa | false | false |
| 21 | 11 | Hitman | $1,954 | -84.7% | 5 | -12 | $390 | $84,374 | 3 | 20th Century Fox International | false | false |
| 22 | 18 | Pulentos, la película | $1,803 | -59.4% | 7 | -2 | $257 | $132,007 | 5 | Bazuca Films | false | false |
| 23 | 16 | Bee Movie | $1,448 | -75.5% | 3 | -5 | $482 | $624,895 | 8 | United International Pictures | false | false |
| 24 | 13 | Priceless | $1,111 | -84.6% | 3 | -4 | $370 | $34,076 | 3 | Transeuropa | false | false |
| 25 | - | The Assassination of Jesse James by the Coward Robert Ford | $1,077 | - | 1 | - | $1,077 | $50,675 | 5 | Warner Bros. | false | false |
| 26 | 21 | Underdog | $322 | -60.7% | 1 | -1 | $322 | $506,231 | 14 | Walt Disney Pictures | false | false |
| 27 | 14 | Shattered | $204 | -97% | 2 | -11 | $102 | $52,309 | 3 | Bazuca Films | false | false |
| 28 | 23 | Bridge to Terabithia | $163 | - | 2 | +1 | $81 | $42,960 | 4 | United International Pictures | false | false |
| 29 | - | I Now Pronounce You Chuck & Larry | $21 | - | 1 | - | $21 | $154,650 | 10 | United International Pictures | false | false |
