| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Love in the Time of Cholera | $96,198 | - | 20 | - | $4,809 | $102,402 | 1 | N/A | true | false |
| 2 | - | Saw IV | $72,485 | - | 29 | - | $2,499 | $72,485 | 1 | N/A | true | false |
| 3 | 1 | National Treasure: Book of Secrets | $61,781 | -48.2% | 34 | - | $1,817 | $529,134 | 3 | N/A | false | false |
| 4 | - | American Gangster | $48,302 | - | 18 | - | $2,683 | $48,302 | 1 | N/A | true | false |
| 5 | 3 | Alvin and the Chipmunks | $45,508 | -35.9% | 35 | - | $1,300 | $676,879 | 4 | N/A | false | false |
| 6 | 4 | Good Luck Chuck | $39,686 | -39.3% | 24 | - | $1,653 | $142,495 | 2 | N/A | false | false |
| 7 | 5 | Bridge to Terabithia | $35,554 | -28.3% | 16 | - | $2,222 | $108,239 | 2 | N/A | false | false |
| 8 | 2 | I Am Legend | $35,444 | -53.1% | 35 | - | $1,012 | $741,805 | 4 | N/A | false | false |
| 9 | - | School for Scoundrels | $27,463 | - | 13 | - | $2,112 | $27,463 | 1 | N/A | true | false |
| 10 | 7 | The Game Plan | $23,247 | -38.1% | 34 | - | $683 | $601,190 | 5 | N/A | false | false |
| 11 | 6 | The Abandoned | $17,259 | -54.2% | 12 | - | $1,438 | $76,107 | 2 | N/A | false | false |
| 12 | 14 | Black Book | $4,023 | -6.5% | 8 | - | $502 | $86,809 | 5 | N/A | false | false |
| 13 | 9 | Enchanted | $3,711 | -57.7% | 34 | - | $109 | $765,456 | 8 | N/A | false | false |
| 14 | 11 | Whisper | $3,616 | -47.3% | 19 | - | $190 | $200,327 | 10 | N/A | false | false |
| 15 | 18 | Superbad | $3,613 | +189.7% | 4 | +3 | $903 | $161,155 | 9 | N/A | false | false |
| 16 | 12 | The Painted Veil | $2,997 | -52.9% | 8 | - | $374 | $61,438 | 6 | N/A | false | false |
| 17 | 17 | Fred Claus | $1,154 | -15.1% | 15 | - | $76 | $160,101 | 7 | N/A | false | false |
| 18 | - | The Heartbreak Kid | $990 | - | 23 | - | $43 | $465,115 | 13 | N/A | false | false |
| 19 | - | 1408 | $684 | - | 20 | - | $34 | $162,392 | 6 | N/A | false | false |
| 20 | 13 | El cantante | $677 | -87.4% | 25 | - | $27 | $157,063 | 5 | N/A | false | false |
| 21 | 15 | Bee Movie | $564 | -74.3% | 43 | - | $13 | $474,581 | 7 | N/A | false | false |
| 22 | - | Lions for Lambs | $430 | - | 14 | - | $30 | $123,364 | 11 | N/A | false | false |
| 23 | 16 | I Now Pronounce You Chuck & Larry | $365 | -77.8% | 32 | - | $11 | $222,866 | 10 | N/A | false | false |
| 24 | 10 | Aliens vs. Predator: Requiem | $254 | -96.4% | 35 | - | $7 | $594,220 | 5 | N/A | false | false |
