| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | I Am Legend | $115,174 | -25.2% | 40 | +2 | $2,879 | $885,771 | 3 | Warner Bros. | false | false |
| 2 | 3 | The Game Plan | $84,982 | +6.1% | 22 | +1 | $3,862 | $360,579 | 3 | Walt Disney Pictures | false | false |
| 3 | - | The Bucket List | $81,711 | - | 19 | - | $4,300 | $81,711 | 1 | Warner Bros. | true | false |
| 4 | 2 | Aliens vs. Predator: Requiem | $69,579 | -31.5% | 33 | - | $2,108 | $244,527 | 2 | 20th Century Fox International | false | false |
| 5 | 4 | Enchanted | $56,456 | -6.2% | 33 | -2 | $1,710 | $1,254,070 | 8 | Walt Disney Pictures | false | false |
| 6 | 5 | National Treasure: Book of Secrets | $50,760 | -7.4% | 38 | -2 | $1,335 | $909,813 | 6 | Walt Disney Pictures | false | false |
| 7 | 6 | Love in the Time of Cholera | $45,395 | -7.7% | 24 | -3 | $1,891 | $251,191 | 3 | 20th Century Fox International | false | false |
| 8 | 7 | Alvin and the Chipmunks | $34,003 | -3.4% | 27 | -4 | $1,259 | $750,252 | 7 | 20th Century Fox International | false | false |
| 9 | - | Hannibal Rising | $25,839 | - | 11 | - | $2,349 | $25,839 | 1 | United International Pictures | true | false |
| 10 | - | School for Scoundrels | $20,768 | - | 14 | - | $1,483 | $20,768 | 1 | Bazuca Films | true | false |
| 11 | 12 | Private Fears in Public Places | $10,018 | +22.7% | 4 | -1 | $2,504 | $27,366 | 2 | Four Films | false | false |
| 12 | 18 | Michael Clayton | $9,259 | +71.2% | 10 | +8 | $925 | $164,663 | 9 | Bazuca Films | false | false |
| 13 | 8 | The Heartbreak Kid | $8,646 | -17.2% | 10 | +2 | $864 | $454,732 | 7 | United International Pictures | false | false |
| 14 | 11 | The Golden Compass | $7,401 | -18.5% | 6 | -5 | $1,233 | $798,151 | 8 | Warner Bros. | false | false |
| 15 | 13 | 30 Days of Night | $6,688 | -16.8% | 10 | - | $668 | $96,421 | 4 | Sony Pictures Releasing | false | false |
| 16 | 17 | Beowulf | $5,372 | -4.6% | 1 | -1 | $5,372 | $658,224 | 11 | Warner Bros. | false | false |
| 17 | 10 | Gone Baby Gone | $5,000 | -48.5% | 4 | - | $1,250 | $20,678 | 2 | Walt Disney Pictures | false | false |
| 18 | 9 | Lonely Hearts | $3,667 | -62.9% | 6 | -2 | $611 | $21,551 | 2 | Bazuca Films | false | false |
| 19 | 15 | Chile puede | $3,633 | -41.9% | 3 | -5 | $1,211 | $351,227 | 5 | Warner Bros. | false | false |
| 20 | 23 | Bee Movie | $2,950 | +103.7% | 1 | -2 | $2,950 | $671,431 | 9 | United International Pictures | false | false |
| 21 | 16 | 1408 | $2,197 | -63.8% | 5 | -3 | $439 | $167,183 | 6 | United International Pictures | false | false |
| 22 | 28 | Bridge to Terabithia | $2,135 | +1,209.8% | 4 | +2 | $533 | $48,570 | 5 | United International Pictures | false | false |
| 23 | 19 | Sleuth | $2,117 | -34.9% | 1 | - | $2,117 | $19,000 | 4 | Sony Pictures Releasing | false | false |
| 24 | 22 | Pulentos, la película | $1,188 | -34.1% | 3 | -4 | $396 | $143,810 | 6 | Bazuca Films | false | false |
| 25 | 21 | Hitman | $905 | -53.7% | 2 | -3 | $452 | $92,962 | 4 | 20th Century Fox International | false | false |
| 26 | 25 | The Assassination of Jesse James by the Coward Robert Ford | $890 | -17.4% | 2 | +1 | $445 | $52,501 | 6 | Warner Bros. | false | false |
| 27 | 14 | Lie with Me | $849 | -87.3% | 4 | -6 | $212 | $13,261 | 2 | - | false | false |
| 28 | 27 | Shattered | $695 | +240.7% | 3 | +1 | $231 | $53,126 | 4 | Bazuca Films | false | false |
| 29 | - | Saw IV | $166 | - | 1 | - | $166 | $286,824 | 9 | Walt Disney Pictures | false | false |
| 30 | 24 | Priceless | $58 | -94.8% | 1 | -2 | $58 | $36,491 | 4 | Transeuropa | false | false |
| 31 | 20 | Venus | $30 | -99% | 1 | -5 | $30 | $24,433 | 3 | Transeuropa | false | false |
