| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 27 Dresses | $196,836 | - | 50 | - | $3,936 | $196,836 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | National Treasure: Book of Secrets | $111,589 | -30.9% | 85 | +3 | $1,312 | $1,093,745 | 4 | Ster-Kinekor Pictures | false | false |
| 3 | 2 | The Bucket List | $84,338 | -38.9% | 40 | +1 | $2,108 | $268,968 | 2 | NuMetro Distribution | false | false |
| 4 | - | Atonement | $60,291 | - | 18 | - | $3,349 | $60,291 | 1 | United International Pictures | true | false |
| 5 | 4 | I Am Legend | $59,646 | -26.4% | 62 | -4 | $962 | $1,700,008 | 6 | NuMetro Distribution | false | false |
| 6 | 3 | Good Luck Chuck | $53,270 | -44.6% | 31 | - | $1,718 | $192,700 | 2 | United International Pictures | false | false |
| 7 | 5 | Alvin and the Chipmunks | $40,780 | -32% | 48 | -5 | $849 | $858,970 | 6 | NuMetro Distribution | false | false |
| 8 | 6 | Saw IV | $35,165 | -39.9% | 39 | -1 | $901 | $230,403 | 3 | Ster-Kinekor Pictures | false | false |
| 9 | 7 | Enchanted | $27,243 | -35.6% | 48 | -7 | $567 | $1,331,469 | 7 | Ster-Kinekor Pictures | false | false |
| 10 | 16 | Talk to Me | $25,254 | +102.5% | 26 | - | $971 | $43,821 | 2 | United International Pictures | false | false |
| 11 | 8 | Arthur and the Invisibles | $24,057 | -38.3% | 30 | - | $801 | $66,254 | 2 | Ster-Kinekor Pictures | false | false |
| 12 | - | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $24,054 | - | 3 | - | $8,018 | $24,054 | 1 | Walt Disney Pictures | true | false |
| 13 | 9 | Elizabeth: The Golden Age | $20,330 | -47.1% | 27 | -11 | $752 | $159,618 | 3 | United International Pictures | false | false |
| 14 | 10 | We Own the Night | $13,641 | -35.4% | 25 | -4 | $545 | $449,741 | 5 | United International Pictures | false | false |
| 15 | 11 | Hitman | $12,959 | -25.4% | 23 | -6 | $563 | $702,662 | 8 | NuMetro Distribution | false | false |
| 16 | 14 | Into the Wild | $11,255 | -21.4% | 10 | - | $1,125 | $33,284 | 2 | United International Pictures | false | false |
| 17 | 13 | Gone Baby Gone | $9,779 | -39.7% | 8 | - | $1,222 | $35,791 | 2 | Ster-Kinekor Pictures | false | false |
| 18 | 18 | Aliens vs. Predator: Requiem | $9,247 | -20.3% | 17 | -4 | $543 | $253,720 | 5 | NuMetro Distribution | false | false |
| 19 | 17 | August Rush | $9,143 | -22.5% | 12 | +8 | $761 | $257,138 | 6 | NuMetro Distribution | false | false |
| 20 | 20 | The Jane Austen Book Club | $6,901 | -33.1% | 10 | +1 | $690 | $160,072 | 5 | Ster-Kinekor Pictures | false | false |
| 21 | 15 | American Gangster | $6,726 | -51% | 12 | -7 | $560 | $773,857 | 9 | United International Pictures | false | false |
| 22 | - | P2 | $6,698 | - | 10 | - | $669 | $21,036 | - | NuMetro Distribution | - | false |
| 23 | 23 | This Christmas | $4,969 | +8.5% | 9 | +1 | $552 | $174,182 | 7 | Ster-Kinekor Pictures | false | false |
| 24 | 21 | Bee Movie | $2,884 | -66.7% | 15 | -10 | $192 | $1,301,338 | 8 | United International Pictures | false | false |
| 25 | 24 | 30 Days of Night | $1,281 | -29.5% | 3 | -1 | $427 | $269,828 | 8 | United International Pictures | false | false |
