| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cloverfield | $95,123 | - | 28 | - | $3,397 | $95,123 | 1 | United International Pictures | true | false |
| 2 | - | Sweeney Todd: The Demon Barber of Fleet Street | $94,751 | - | 15 | - | $6,316 | $94,751 | 1 | Warner Bros. | true | false |
| 3 | - | The Water Horse | $94,381 | - | 24 | - | $3,932 | $94,381 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | The Game Plan | $79,010 | -7% | 20 | -2 | $3,950 | $503,820 | 4 | Walt Disney Pictures | false | false |
| 5 | 1 | I Am Legend | $71,829 | -37.6% | 39 | -1 | $1,841 | $1,025,852 | 4 | Warner Bros. | false | false |
| 6 | 3 | The Bucket List | $61,493 | -24.7% | 18 | -1 | $3,416 | $193,794 | 2 | Warner Bros. | false | false |
| 7 | - | 27 Dresses | $51,880 | - | 25 | - | $2,075 | $51,880 | 1 | 20th Century Fox International | true | false |
| 8 | 4 | Aliens vs. Predator: Requiem | $34,007 | -51.1% | 32 | -1 | $1,062 | $339,076 | 3 | 20th Century Fox International | false | false |
| 9 | 5 | Enchanted | $26,191 | -53.6% | 30 | -3 | $873 | $1,316,441 | 9 | Walt Disney Pictures | false | false |
| 10 | 6 | National Treasure: Book of Secrets | $19,939 | -60.7% | 25 | -13 | $797 | $957,666 | 7 | Walt Disney Pictures | false | false |
| 11 | 7 | Love in the Time of Cholera | $16,956 | -62.6% | 10 | -14 | $1,695 | $296,556 | 4 | 20th Century Fox International | false | false |
| 12 | 8 | Alvin and the Chipmunks | $13,517 | -60.2% | 22 | -5 | $614 | $789,315 | 8 | 20th Century Fox International | false | false |
| 13 | 9 | Hannibal Rising | $9,519 | -63.2% | 9 | -2 | $1,057 | $51,490 | 2 | United International Pictures | false | false |
| 14 | 12 | Michael Clayton | $5,931 | -35.9% | 4 | -6 | $1,482 | $175,959 | 10 | Bazuca Films | false | false |
| 15 | 11 | Private Fears in Public Places | $5,133 | -48.8% | 3 | -1 | $1,711 | $35,563 | 3 | Four Films | false | false |
| 16 | 16 | Beowulf | $4,062 | -24.4% | 1 | - | $4,062 | $665,119 | 12 | Warner Bros. | false | false |
| 17 | - | Le Sauvage | $2,935 | - | 6 | - | $489 | $2,935 | 1 | Four Films | true | false |
| 18 | 13 | The Heartbreak Kid | $2,470 | -71.4% | 4 | -6 | $617 | $465,002 | 8 | United International Pictures | false | false |
| 19 | 10 | School for Scoundrels | $2,050 | -90.1% | 5 | -9 | $410 | $35,343 | 2 | Bazuca Films | false | false |
| 20 | 21 | 1408 | $1,943 | -11.6% | 4 | -1 | $485 | $171,763 | 7 | United International Pictures | false | false |
| 21 | 19 | Chile puede | $1,732 | -52.3% | 1 | -2 | $1,732 | $354,717 | 6 | Warner Bros. | false | false |
| 22 | 22 | Bridge to Terabithia | $1,713 | -19.8% | 4 | - | $428 | $54,108 | 6 | United International Pictures | false | false |
| 23 | 15 | 30 Days of Night | $1,522 | -77.2% | 4 | -6 | $380 | $102,749 | 5 | Sony Pictures Releasing | false | false |
| 24 | 25 | Hitman | $1,411 | +55.9% | 3 | +1 | $470 | $95,676 | 5 | 20th Century Fox International | false | false |
| 25 | 14 | The Golden Compass | $1,353 | -81.7% | 3 | -3 | $451 | $804,248 | 9 | Warner Bros. | false | false |
| 26 | 20 | Bee Movie | $721 | -75.6% | 1 | - | $721 | $673,669 | 10 | United International Pictures | false | false |
| 27 | 23 | Sleuth | $394 | -81.4% | 1 | - | $394 | $20,159 | 5 | Sony Pictures Releasing | false | false |
| 28 | 24 | Pulentos, la película | $220 | -81.5% | 2 | -1 | $110 | $145,009 | 7 | Bazuca Films | false | false |
| 29 | 18 | Lonely Hearts | $132 | -96.4% | 1 | -5 | $132 | $23,435 | 3 | Bazuca Films | false | false |
| 30 | 27 | Lie with Me | $34 | -96% | 1 | -3 | $34 | $13,835 | 3 | - | false | false |
