| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | What Happens in Vegas | $529,568 | +26.8% | 70 | -3 | $7,565 | $1,155,803 | 2 | 20th Century Fox International | false | false |
| 2 | - | Made of Honor | $253,265 | - | 42 | - | $6,030 | $266,029 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Iron Man | $213,312 | -5.1% | 64 | -1 | $3,333 | $1,173,154 | 3 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | The Wave | $135,596 | +67.8% | 23 | +1 | $5,895 | $456,087 | 3 | Rialto Distribution | false | false |
| 5 | 4 | Welcome to the Sticks | $83,124 | +34.4% | 18 | - | $4,618 | $4,861,216 | 12 | Pathé | false | false |
| 6 | 5 | Fool's Gold | $60,943 | +10.1% | 34 | -8 | $1,792 | $672,016 | 4 | Warner Bros. | false | false |
| 7 | 16 | The Game Plan | $48,261 | +234.6% | 25 | -3 | $1,930 | $184,389 | 3 | Walt Disney Pictures | false | false |
| 8 | 8 | Street Kings | $43,937 | +48.5% | 15 | -2 | $2,929 | $616,383 | 5 | 20th Century Fox International | false | false |
| 9 | 14 | Summer | $37,501 | +113.2% | 32 | -3 | $1,171 | $432,915 | 5 | Walt Disney Pictures | false | false |
| 10 | 13 | Once | $36,456 | +95.5% | 6 | - | $6,076 | $354,847 | 6 | Ascot Elite Entertainment Group | false | false |
| 11 | 6 | 27 Dresses | $34,009 | +10% | 12 | -1 | $2,834 | $1,367,033 | 14 | 20th Century Fox International | false | false |
| 12 | 10 | Shine a Light | $32,470 | +48.2% | 12 | - | $2,705 | $301,820 | 5 | Filmcoopi | false | false |
| 13 | - | Nim's Island | $31,535 | - | 7 | - | $4,505 | $217,974 | 6 | Ascot Elite Entertainment Group | false | false |
| 14 | - | Horton Hears a Who! | $30,634 | - | 18 | - | $1,701 | $1,992,110 | 10 | 20th Century Fox International | false | false |
| 15 | 17 | Cherry Blossoms | $30,338 | +113.3% | 14 | +1 | $2,167 | $550,812 | 8 | Ascot Elite Entertainment Group | false | false |
| 16 | - | Days and Clouds | $28,449 | - | 10 | - | $2,844 | $382,167 | 29 | Filmcoopi | false | false |
| 17 | - | The Drummer | $28,078 | - | 9 | - | $3,119 | $28,078 | 1 | Filmcoopi | true | false |
| 18 | 7 | Step Up 2: The Streets | $25,355 | -15.9% | 17 | -12 | $1,491 | $3,219,461 | 10 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | Lemon Tree | $23,777 | +43.4% | 5 | - | $4,755 | $76,770 | 3 | Agora Films | false | false |
| 20 | 18 | Cash | $22,903 | +73.5% | 7 | - | $3,271 | $129,140 | 4 | Pathé | false | false |
| 21 | 12 | The Other Boleyn Girl | $21,250 | +10.5% | 14 | -1 | $1,517 | $867,286 | 11 | Universal Pictures International (UPI) | false | false |
| 22 | 9 | Speed Racer | $16,940 | -26.6% | 29 | -24 | $584 | $54,135 | 2 | Warner Bros. | false | false |
| 23 | 21 | No Country for Old Men | $11,313 | +74.7% | 7 | +1 | $1,616 | $2,191,539 | 17 | Universal Pictures International (UPI) | false | false |
| 24 | 20 | Vantage Point | $10,566 | -4.4% | 6 | - | $1,761 | $445,672 | 12 | Walt Disney Pictures | false | false |
| 25 | - | Superhero Movie | $8,772 | - | 1 | - | $8,772 | $8,772 | 1 | Ascot Elite Entertainment Group | true | false |
| 26 | - | Untraceable | $8,388 | - | 6 | - | $1,398 | $513,894 | 11 | Universal Pictures International (UPI) | false | false |
| 27 | 22 | Definitely, Maybe | $1,624 | -32.7% | 3 | +1 | $541 | $488,777 | 8 | Universal Pictures International (UPI) | false | false |
| 28 | 23 | The Spiderwick Chronicles | $1,403 | +71.7% | 2 | -3 | $701 | $432,931 | 9 | Universal Pictures International (UPI) | false | false |
