| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $359,112 | - | 93 | - | $3,861 | $359,112 | 1 | United International Pictures | true | false |
| 2 | 1 | What Happens in Vegas | $192,917 | -32.1% | 60 | - | $3,215 | $566,322 | 2 | NuMetro Distribution | false | false |
| 3 | 2 | Iron Man | $107,858 | -20.3% | 76 | - | $1,419 | $1,137,113 | 4 | United International Pictures | false | false |
| 4 | 4 | Made of Honor | $65,689 | -4.4% | 52 | -3 | $1,263 | $659,645 | 4 | United International Pictures | false | false |
| 5 | 3 | The Forbidden Kingdom | $61,537 | -40.3% | 46 | - | $1,337 | $198,932 | 2 | NuMetro Distribution | false | false |
| 6 | - | The Eye | $31,084 | - | 29 | - | $1,071 | $31,084 | 1 | NuMetro Distribution | true | false |
| 7 | 5 | Awake | $27,522 | -15.2% | 30 | - | $917 | $73,840 | 2 | Ster-Kinekor Pictures | false | false |
| 8 | 6 | Nim's Island | $21,878 | -15.2% | 36 | -4 | $607 | $398,477 | 5 | NuMetro Distribution | false | false |
| 9 | 7 | Mad Money | $18,923 | -24.3% | 34 | -9 | $556 | $504,800 | 6 | NuMetro Distribution | false | false |
| 10 | 9 | 88 Minutes | $15,165 | -20.5% | 20 | - | $758 | $87,696 | 3 | NuMetro Distribution | false | false |
| 11 | 8 | 21 | $11,420 | -40.3% | 14 | -6 | $815 | $87,008 | 3 | United International Pictures | false | false |
| 12 | 10 | The Game Plan | $10,203 | -26% | 19 | -8 | $537 | $1,392,650 | 10 | Ster-Kinekor Pictures | false | false |
| 13 | 11 | Bakgat! | $9,329 | -29.7% | 13 | -7 | $717 | $364,761 | 7 | Ster-Kinekor Pictures | false | false |
| 14 | - | Be Kind Rewind | $7,822 | - | 10 | - | $782 | $7,822 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 15 | Horton Hears a Who! | $7,500 | -6.2% | 22 | -5 | $340 | $1,022,212 | 9 | NuMetro Distribution | false | false |
| 16 | 12 | Dan in Real Life | $7,167 | -42.2% | 14 | -10 | $511 | $267,573 | 5 | Ster-Kinekor Pictures | false | false |
| 17 | 13 | First Sunday | $7,132 | -29.3% | 12 | -3 | $594 | $139,004 | 5 | United International Pictures | false | false |
| 18 | 14 | Step Up 2: The Streets | $5,360 | -36.8% | 19 | -2 | $282 | $1,539,565 | 11 | NuMetro Distribution | false | false |
| 19 | 18 | Death Defying Acts | $5,013 | -20.8% | 16 | - | $313 | $14,485 | 2 | United International Pictures | false | false |
| 20 | 21 | How She Move | $3,195 | +13.5% | 7 | -2 | $456 | $80,777 | 6 | United International Pictures | false | false |
| 21 | 19 | The Mist | $2,590 | -54.1% | 9 | -6 | $287 | $24,949 | 3 | Ster-Kinekor Pictures | false | false |
| 22 | 20 | Untraceable | $2,311 | -49.8% | 11 | -8 | $210 | $211,880 | 5 | United International Pictures | false | false |
| 23 | 22 | Vantage Point | $974 | -0.5% | 2 | -1 | $487 | $360,554 | 8 | United International Pictures | false | false |
| 24 | 24 | The Spiderwick Chronicles | $262 | -29.9% | 1 | - | $262 | $361,850 | 10 | United International Pictures | false | false |
