| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $50,339 | - | 9 | - | $5,593 | $81,683 | 1 | - | true | false |
| 2 | 1 | What Happens in Vegas | $6,731 | -19% | 5 | - | $1,346 | $44,538 | 3 | Tuck | false | false |
| 3 | 3 | 21 | $1,321 | -49.4% | 5 | - | $264 | $31,365 | 5 | Tuck | false | false |
| 4 | 2 | Iron Man | $1,262 | -52.5% | 4 | - | $315 | $31,341 | 4 | - | false | false |
| 5 | 4 | Speed Racer | $507 | -54.7% | 4 | - | $126 | $4,039 | 3 | Tuck | false | false |
| 6 | 8 | Fados | $505 | -25.2% | 2 | - | $252 | $5,643 | 3 | - | false | false |
| 7 | 6 | Fool's Gold | $499 | -33.1% | 5 | - | $99 | $57,772 | 8 | Tuck | false | false |
| 8 | 5 | Obituary for Escobar | $415 | -62.5% | 17 | - | $24 | $562,699 | 12 | Cinears | false | false |
| 9 | 18 | Paper Prince | $405 | +122.5% | 4 | - | $101 | $12,178 | 8 | Art Vista | false | false |
| 10 | 15 | Vantage Point | $390 | -10.1% | 4 | - | $97 | $15,049 | 6 | Tuck | false | false |
| 11 | 7 | Step Up 2: The Streets | $365 | -49.9% | 3 | - | $121 | $14,456 | 6 | Mirius | false | false |
| 12 | 12 | Asterix at the Olympic Games | $307 | -35% | 7 | - | $43 | $157,144 | 13 | Pro Vision | false | false |
| 13 | 16 | Horton Hears a Who! | $304 | -28.8% | 6 | - | $50 | $67,781 | 11 | Tuck | false | false |
| 14 | 10 | Tears for Sale | $295 | -41.6% | 20 | - | $14 | $605,429 | 18 | Mirius | false | false |
| 15 | 31 | 10,000 BC | $241 | +534.2% | 5 | - | $48 | $85,295 | 11 | Tuck | false | false |
| 16 | 9 | The Spiderwick Chronicles | $214 | -65.4% | 6 | - | $35 | $20,690 | 7 | - | false | false |
| 17 | 20 | The Bucket List | $187 | +25.5% | 2 | - | $93 | $44,189 | 9 | Tuck | false | false |
| 18 | 22 | Love in the Time of Cholera | $172 | +38.7% | 3 | - | $57 | $40,899 | 13 | Mirius | false | false |
| 19 | - | I Am Legend | $151 | - | 5 | - | $30 | $66,396 | 21 | Tuck | false | false |
| 20 | 14 | The Water Horse | $114 | -74.1% | 4 | - | $28 | $14,131 | 10 | Tuck | false | false |
| 21 | 13 | Street Kings | $109 | -75.9% | 3 | - | $36 | $15,373 | 7 | Tuck | false | false |
| 22 | 40 | Nightwatching | $96 | +4,700% | 1 | - | $96 | $10,929 | 6 | Pro Vision | false | false |
| 23 | - | Aliens vs. Predator: Requiem | $89 | - | 4 | - | $22 | $46,883 | 23 | Tuck | false | false |
| 24 | 37 | Sukiyaki Western Django | $75 | +368.8% | 1 | - | $75 | $6,483 | 9 | N/A | false | false |
| 25 | 21 | Atonement | $73 | -48.6% | 3 | - | $24 | $36,206 | 12 | - | false | false |
| 26 | 35 | Paranoid Park | $73 | +170.4% | 1 | - | $73 | $5,797 | 4 | N/A | false | false |
| 27 | 17 | 27 Dresses | $63 | -77.4% | 5 | - | $12 | $42,948 | 15 | Tuck | false | false |
| 28 | 39 | No Country for Old Men | $52 | +550% | 2 | - | $26 | $45,182 | 13 | - | false | false |
| 29 | 27 | Juno | $50 | -31.5% | 3 | - | $16 | $17,480 | 16 | Pro Vision | false | false |
| 30 | 25 | Lust, Caution | $46 | -40.3% | 1 | - | $46 | $23,430 | 13 | N/A | false | false |
| 31 | 30 | Sleuth | $44 | -13.7% | 1 | - | $44 | $4,360 | 8 | - | false | false |
| 32 | 23 | Jumper | $38 | -54.2% | 5 | - | $7 | $70,615 | 16 | Tuck | false | false |
| 33 | 38 | Shadows | $35 | +150% | 2 | - | $17 | $6,985 | 7 | Mirius | false | false |
| 34 | 34 | Bratz | $34 | +17.2% | 2 | - | $17 | $5,857 | 20 | N/A | false | false |
| 35 | - | A Girl Cut in Two | $34 | - | 1 | - | $34 | $7,121 | 8 | - | false | false |
| 36 | 29 | Cloverfield | $23 | -59.6% | 2 | - | $11 | $22,242 | 16 | - | false | false |
| 37 | 36 | The Darjeeling Limited | $17 | -15% | 1 | - | $17 | $19,315 | 10 | Tuck | false | false |
| 38 | 26 | Eastern Promises | $12 | -84.4% | 1 | - | $12 | $13,784 | 11 | N/A | false | false |
| 39 | 33 | The Call of Wild | $11 | -65.6% | 1 | - | $11 | $3,294 | 6 | N/A | false | false |
| 40 | 32 | Goodbye Bafana | $6 | -83.8% | 2 | - | $3 | $577 | 4 | N/A | false | false |
