| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Sex and the City | $73,611 | - | 6 | - | $12,268 | $136,557 | 1 | Tuck | true | false |
| 2 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $15,594 | -44.9% | 9 | - | $1,732 | $164,876 | 3 | - | false | false |
| 3 | - | The Incredible Hulk | $8,001 | - | 4 | - | $2,000 | $10,161 | 1 | - | true | false |
| 4 | - | The Happening | $5,833 | - | 3 | - | $1,944 | $7,044 | 1 | Tuck | true | false |
| 5 | 2 | What Happens in Vegas | $5,235 | -23.8% | 5 | - | $1,047 | $64,694 | 5 | Tuck | false | false |
| 6 | 5 | Horton Hears a Who! | $557 | -38.5% | 6 | - | $92 | $68,798 | 13 | Tuck | false | false |
| 7 | 3 | 21 | $477 | -72.8% | 5 | - | $95 | $34,956 | 7 | Tuck | false | false |
| 8 | 4 | Iron Man | $420 | -72.4% | 4 | - | $105 | $34,761 | 6 | - | false | false |
| 9 | 10 | Step Up 2: The Streets | $404 | +4.4% | 3 | - | $134 | $16,026 | 8 | Mirius | false | false |
| 10 | 16 | Love in the Time of Cholera | $288 | +55.7% | 3 | - | $96 | $40,913 | 15 | Mirius | false | false |
| 11 | 9 | Vantage Point | $212 | -55.3% | 4 | - | $53 | $16,299 | 8 | Tuck | false | false |
| 12 | 13 | Street Kings | $155 | -41.9% | 3 | - | $51 | $15,891 | 9 | Tuck | false | false |
| 13 | 17 | Paper Prince | $135 | -20.1% | 4 | - | $33 | $12,489 | 10 | Art Vista | false | false |
| 14 | - | 4 Months, 3 Weeks and 2 Days | $116 | - | 2 | - | $58 | $17,674 | 13 | Cinears | false | false |
| 15 | 14 | The Spiderwick Chronicles | $105 | -59.1% | 6 | - | $17 | $21,487 | 9 | - | false | false |
| 16 | 7 | Speed Racer | $105 | -79.7% | 4 | - | $26 | $5,482 | 5 | Tuck | false | false |
| 17 | 15 | The Water Horse | $98 | -48.1% | 4 | - | $24 | $15,078 | 12 | Tuck | false | false |
| 18 | 12 | Tears for Sale | $85 | -70.2% | 20 | - | $4 | $595,315 | 20 | Mirius | false | false |
| 19 | 24 | Alvin and the Chipmunks | $75 | +23% | 4 | - | $18 | $50,886 | 23 | Tuck | false | false |
| 20 | 11 | The Bucket List | $72 | -80.1% | 2 | - | $36 | $44,283 | 11 | Tuck | false | false |
| 21 | 19 | P.S. I Love You | $62 | -58.1% | 2 | - | $31 | $30,439 | 26 | Mirius | false | false |
| 22 | 6 | Obituary for Escobar | $53 | -91.6% | 17 | - | $3 | $535,218 | 14 | Cinears | false | false |
| 23 | - | 10,000 BC | $31 | - | 5 | - | $6 | $84,167 | 13 | Tuck | false | false |
| 24 | 25 | No Country for Old Men | $28 | -42.9% | 2 | - | $14 | $44,520 | 15 | - | false | false |
| 25 | 30 | Eastern Promises | $28 | +86.7% | 1 | - | $28 | $13,666 | 13 | N/A | false | false |
| 26 | - | I Am Legend | $16 | - | 5 | - | $3 | $67,556 | 23 | Tuck | false | false |
| 27 | - | It's Hard to Be Nice | $14 | - | 4 | - | $3 | $3,535 | 10 | N/A | false | false |
