| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Incredible Hulk | $1,234,376 | -44.3% | 556 | -1 | $2,220 | $4,573,453 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | Sex and the City | $1,064,771 | -47.9% | 352 | -7 | $3,024 | $4,321,944 | 2 | TriPictures | false | false |
| 3 | 3 | The Happening | $739,328 | -38.3% | 373 | -14 | $1,982 | $6,779,353 | 3 | 20th Century Fox International | false | false |
| 4 | 4 | Indiana Jones and the Kingdom of the Crystal Skull | $628,155 | -21.7% | 338 | -124 | $1,858 | $29,439,447 | 6 | Universal Pictures International (UPI) | false | false |
| 5 | - | Forgetting Sarah Marshall | $613,538 | - | 252 | - | $2,434 | $613,538 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | Rivales | $313,300 | - | 240 | - | $1,305 | $313,300 | 1 | N/A | true | false |
| 7 | 5 | Made of Honor | $230,307 | -33.6% | 278 | -31 | $828 | $5,649,515 | 5 | Sony Pictures Releasing | false | false |
| 8 | 8 | The Ugly Duckling and Me! | $170,925 | +9.8% | 147 | -1 | $1,162 | $487,349 | 2 | Filmax | false | false |
| 9 | 9 | Before the Devil Knows You're Dead | $137,963 | -2.8% | 99 | -6 | $1,393 | $2,676,571 | 6 | Baditri | false | false |
| 10 | 7 | The Mist | $120,636 | -24.2% | 166 | -65 | $726 | $3,099,324 | 5 | Notro Films | false | false |
| 11 | - | Timecrimes | $111,066 | - | 77 | - | $1,442 | $111,066 | 1 | N/A | true | false |
| 12 | 6 | What Happens in Vegas | $107,971 | -32.7% | 189 | -52 | $571 | $11,568,055 | 8 | 20th Century Fox International | false | false |
| 13 | 10 | Quiet Chaos | $76,595 | -12.1% | 59 | -1 | $1,298 | $220,643 | 2 | Alta Films | false | false |
| 14 | 11 | Emotional Arithmetic | $59,418 | -13.9% | 42 | -1 | $1,414 | $637,459 | 4 | Golem Distribución | false | false |
| 15 | 12 | Margot at the Wedding | $53,209 | -13.7% | 24 | - | $2,217 | $150,695 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | 15 | 3:19 2008 Re-release | $36,397 | -32.1% | 70 | -9 | $519 | $136,036 | 2 | N/A | false | false |
| 17 | 16 | Chef's Special | $34,312 | -19.6% | 60 | -23 | $571 | $7,665,779 | 12 | Warner Bros. | false | false |
| 18 | 14 | Leatherheads | $31,286 | -41.9% | 69 | -27 | $453 | $888,551 | 4 | Universal Pictures International (UPI) | false | false |
| 19 | 17 | 88 Minutes | $29,375 | -19.1% | 71 | -32 | $413 | $3,791,308 | 9 | Filmax | false | false |
| 20 | 18 | Iron Man | $25,938 | -17.3% | 84 | -30 | $308 | $11,612,712 | 9 | Sony Pictures Releasing | false | false |
| 21 | 13 | Pretextos | $25,570 | -54.9% | 27 | -14 | $947 | $278,350 | 3 | Golem Distribución | false | false |
| 22 | 19 | Grace Is Gone | $18,507 | -25.4% | 26 | -12 | $711 | $164,855 | 3 | Notro Films | false | false |
| 23 | 24 | Courthouse on Horseback | $13,464 | +1.2% | 13 | - | $1,035 | $292,737 | 6 | Karma Films | false | false |
| 24 | 20 | An American Crime | $12,460 | -39% | 28 | -18 | $445 | $154,110 | 3 | Filmax | false | false |
| 25 | 22 | Prom Night | $11,203 | -29% | 33 | -24 | $339 | $1,817,795 | 7 | Sony Pictures Releasing | false | false |
| 26 | 25 | Horton Hears a Who! | $11,008 | -11.9% | 59 | +44 | $186 | $11,076,177 | 16 | 20th Century Fox International | false | false |
| 27 | 28 | Island of Lost Souls | $9,703 | -16% | 36 | -5 | $269 | $408,900 | 7 | - | false | false |
| 28 | 27 | 21 | $8,902 | -25% | 21 | -18 | $423 | $6,734,148 | 12 | Sony Pictures Releasing | false | false |
| 29 | 35 | Late Bloomers | $8,823 | +15.3% | 13 | +1 | $678 | $388,949 | 8 | - | false | false |
| 30 | 29 | Elegy | $8,657 | -21.3% | 16 | -10 | $541 | $3,837,773 | 11 | On Pictures | false | false |
| 31 | 34 | The Princess of Nebraska | $7,762 | -5.8% | 6 | - | $1,293 | $21,621 | 2 | Karma Films | false | false |
| 32 | 37 | The Edge of Heaven | $7,381 | +4.3% | 8 | -2 | $922 | $1,292,669 | 16 | Golem Distribución | false | false |
| 33 | 32 | A Thousand Years of Good Prayers | $7,363 | -20.4% | 21 | -2 | $350 | $1,129,316 | 11 | Karma Films | false | false |
| 34 | 26 | Rudy: The Return of the Racing Pig | $6,957 | -42.7% | 41 | -3 | $169 | $407,216 | 10 | - | false | false |
| 35 | 31 | Speed Racer | $6,561 | -32.7% | 54 | -31 | $121 | $2,000,492 | 8 | Warner Bros. | false | false |
| 36 | 36 | It's All Gone Pete Tong 2008 Re-release | $5,938 | -17.3% | 12 | -3 | $494 | $21,434 | 2 | - | false | false |
| 37 | - | Sultanes del Sur | $5,899 | - | 113 | - | $52 | $254,407 | 7 | Filmax | false | false |
| 38 | 40 | Death Sentence | $5,433 | -10.7% | 19 | -14 | $285 | $1,227,609 | 7 | TriPictures | false | false |
| 39 | 23 | 12 | $5,253 | -64.6% | 16 | -12 | $328 | $98,568 | 3 | - | false | false |
| 40 | 39 | Street Kings | $5,060 | -24.5% | 18 | +9 | $281 | $4,100,461 | 10 | 20th Century Fox International | false | false |
| 41 | 44 | A Girl Cut in Two | $4,798 | +9.6% | 16 | - | $299 | $493,500 | 7 | Wanda Visión S.A. | false | false |
| 42 | 43 | Lars and the Real Girl | $4,552 | -8.6% | 6 | -1 | $758 | $271,281 | 10 | Versus Entertainment | false | false |
| 43 | 45 | Alexandra | $4,063 | +7.2% | 5 | - | $812 | $80,429 | 5 | Sagrera TV | false | false |
| 44 | 47 | The Savages | $3,738 | +2.3% | 9 | -4 | $415 | $946,145 | 13 | 20th Century Fox International | false | false |
| 45 | 51 | 8 Dates | $3,590 | +23.8% | 4 | - | $897 | $1,326,025 | 11 | Alta Films | false | false |
| 46 | 42 | Wonderful Town | $3,535 | -31.1% | 2 | - | $1,767 | $12,700 | 2 | N/A | false | false |
| 47 | 41 | Drillbit Taylor | $3,194 | -39.1% | 12 | -8 | $266 | $418,417 | 7 | Universal Pictures International (UPI) | false | false |
| 48 | 52 | Bab'Aziz: The Prince That Contemplated His Soul | $3,061 | +14.7% | 3 | - | $1,020 | $241,759 | 17 | Karma Films | false | false |
| 49 | 49 | The Water Horse | $3,042 | -7.3% | 11 | -7 | $276 | $3,433,352 | 17 | Sony Pictures Releasing | false | false |
| 50 | - | The Contract | $2,986 | - | 9 | - | $331 | $1,389,179 | 13 | Filmax | false | false |
| 51 | 48 | The Yacoubian Building | $2,936 | -13.1% | 2 | - | $1,468 | $32,527 | 5 | Barton Films | false | false |
| 52 | 50 | Be Kind Rewind | $2,857 | -7.3% | 4 | +3 | $714 | $516,023 | 12 | Universal Pictures International (UPI) | false | false |
| 53 | - | The Dead Girl | $2,711 | - | 15 | - | $180 | $143,879 | 5 | Filmax | false | false |
| 54 | 46 | Before the Fall | $2,131 | -42.5% | 1 | - | $2,131 | $328,946 | 10 | Universal Pictures International (UPI) | false | false |
| 55 | 55 | The Duchess of Langeais | $2,094 | +6.4% | 4 | -3 | $523 | $182,701 | 9 | Baditri | false | false |
| 56 | 56 | Days of Darkness | $1,748 | -5.8% | 4 | -2 | $437 | $366,615 | 12 | Golem Distribución | false | false |
| 57 | 54 | The Counterfeiters | $1,582 | -26% | 5 | -5 | $316 | $3,806,912 | 16 | Wanda Visión S.A. | false | false |
| 58 | 62 | Fool's Gold | $1,512 | +20% | 5 | -1 | $302 | $2,907,651 | 10 | Warner Bros. | false | false |
| 59 | 58 | Cashback | $1,488 | +2.9% | 4 | - | $372 | $202,782 | 12 | - | false | false |
| 60 | 71 | Rendition | $1,324 | +200.2% | 4 | +1 | $331 | $1,328,472 | 11 | TriPictures | false | false |
| 61 | 53 | Honeydripper | $1,269 | -48.7% | 3 | -2 | $423 | $81,313 | 7 | Golem Distribución | false | false |
| 62 | 61 | The Spiderwick Chronicles | $1,145 | -9.9% | 8 | -2 | $143 | $5,642,734 | 16 | Universal Pictures International (UPI) | false | false |
| 63 | 60 | The Kite Runner | $1,139 | -15.3% | 3 | - | $379 | $1,837,956 | 17 | Universal Pictures International (UPI) | false | false |
| 64 | 64 | Untraceable | $935 | +1.7% | 3 | - | $311 | $1,853,046 | 13 | Universal Pictures International (UPI) | false | false |
| 65 | 59 | Franklin and the Turtle Lake Treasure | $909 | -36.3% | 8 | -3 | $113 | $751,772 | 19 | Wanda Visión S.A. | false | false |
| 66 | 66 | The Ruins | $832 | +13.5% | 3 | - | $277 | $783,765 | 11 | Universal Pictures International (UPI) | false | false |
| 67 | 65 | Things We Lost in the Fire | $801 | -3.3% | 5 | -2 | $160 | $310,079 | 10 | Universal Pictures International (UPI) | false | false |
| 68 | 73 | Buddha Collapsed Out of Shame | $747 | +70.9% | 3 | +1 | $249 | $478,189 | 18 | Wanda Visión S.A. | false | false |
| 69 | - | Cowards | $662 | - | 7 | - | $94 | $1,473,892 | 10 | Filmax | false | false |
| 70 | 57 | Encarnacion | $660 | -56.7% | 4 | -1 | $165 | $30,795 | 4 | Wanda Visión S.A. | false | false |
| 71 | 76 | Into the Wild | $477 | +90% | 2 | +1 | $238 | $772,338 | 23 | Universal Pictures International (UPI) | false | false |
| 72 | 75 | Caramel | $273 | -23.3% | 1 | - | $273 | $1,848,875 | 24 | Alta Films | false | false |
| 73 | 67 | Definitely, Maybe | $227 | -62% | 4 | -5 | $56 | $297,053 | 8 | Universal Pictures International (UPI) | false | false |
| 74 | 80 | No Country for Old Men | $100 | +31.6% | 1 | - | $100 | $10,785,397 | 21 | Universal Pictures International (UPI) | false | false |
