| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hancock | $1,189,185 | - | 93 | - | $12,786 | $1,244,358 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Kung Fu Panda | $601,910 | - | 74 | - | $8,133 | $635,475 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | The Chronicles of Narnia: Prince Caspian | $223,999 | +54.2% | 31 | - | $7,225 | $467,042 | 2 | Walt Disney Pictures | false | false |
| 4 | 3 | Indiana Jones and the Kingdom of the Crystal Skull | $145,595 | +68.6% | 41 | -23 | $3,551 | $5,371,271 | 7 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | Sex and the City | $138,812 | +33.4% | 42 | -35 | $3,305 | $3,251,683 | 6 | Warner Bros. | false | false |
| 6 | 5 | Welcome to the Sticks | $138,348 | +122.6% | 18 | -7 | $7,686 | $5,305,336 | 19 | Pathé | false | false |
| 7 | 20 | The Incredible Hulk | $107,598 | +2,482.1% | 26 | +22 | $4,138 | $146,252 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 4 | 21 | $77,003 | +11.4% | 122 | +96 | $631 | $695,013 | 5 | Walt Disney Pictures | false | false |
| 9 | 6 | The Happening | $59,789 | +4.8% | 27 | -17 | $2,214 | $528,772 | 4 | 20th Century Fox International | false | false |
| 10 | 8 | Made of Honor | $55,212 | +66.6% | 16 | -14 | $3,450 | $886,191 | 8 | Walt Disney Pictures | false | false |
| 11 | 7 | Forgetting Sarah Marshall | $51,501 | +38.6% | 20 | -1 | $2,575 | $336,747 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | 2 Alone in Paris | $41,996 | +103.8% | 7 | - | $5,999 | $84,315 | 2 | JMH Distribution | false | false |
| 13 | 11 | Street Kings | $33,869 | +71.3% | 13 | +1 | $2,605 | $731,496 | 12 | 20th Century Fox International | false | false |
| 14 | 9 | What Happens in Vegas | $27,751 | +27% | 10 | -13 | $2,775 | $2,180,599 | 9 | 20th Century Fox International | false | false |
| 15 | 13 | Waltz with Bashir | $22,283 | +133.6% | 5 | - | $4,456 | $40,373 | 2 | Frenetic Films | false | false |
| 16 | - | Wanted | $18,201 | - | 4 | - | $4,550 | $21,123 | 1 | Universal Pictures International (UPI) | true | false |
| 17 | 12 | The Wave | $16,158 | +49.8% | 10 | -12 | $1,615 | $866,893 | 10 | Rialto Distribution | false | false |
| 18 | 14 | The Nanny Diaries | $16,092 | +102.4% | 8 | - | $2,011 | $96,389 | 4 | Ascot Elite Entertainment Group | false | false |
| 19 | 16 | The Game Plan | $15,742 | +187.2% | 18 | - | $874 | $387,568 | 10 | Walt Disney Pictures | false | false |
| 20 | - | I Always Wanted to Be a Gangster | $13,538 | - | 4 | - | $3,384 | $110,389 | 12 | Frenetic Films | false | false |
| 21 | 22 | Iron Man | $1,291 | -48.2% | 2 | -3 | $645 | $1,361,378 | 10 | Universal Pictures International (UPI) | false | false |
