| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Wanted | $1,509,477 | - | 393 | - | $3,840 | $2,194,357 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Un'estate al mare | $1,358,677 | -34.1% | 569 | -7 | $2,387 | $4,779,720 | 2 | Medusa Distribuzione | false | false |
| 3 | 6 | Sex and the City | $504,311 | +292.7% | 61 | -78 | $8,267 | $10,362,860 | 6 | 01 Distribution | false | false |
| 4 | 2 | The Incredible Hulk | $457,190 | -48.9% | 341 | -128 | $1,340 | $5,271,194 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | - | Boogeyman 2 | $198,928 | - | 187 | - | $1,063 | $199,030 | 1 | Eagle Pictures | true | false |
| 6 | - | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | $175,646 | - | 34 | - | $5,166 | $175,646 | 1 | Mikado Film | true | false |
| 7 | 3 | Street Kings | $163,000 | -52.5% | 209 | -38 | $779 | $690,457 | 2 | 20th Century Fox International | false | false |
| 8 | 4 | The Happening | $129,408 | -54.1% | 114 | -80 | $1,135 | $3,653,047 | 4 | 20th Century Fox International | false | false |
| 9 | 5 | Made of Honor | $80,695 | -60.7% | 102 | -111 | $791 | $2,609,674 | 4 | Sony Pictures Releasing | false | false |
| 10 | 9 | Il Divo | $74,561 | -34% | 65 | -61 | $1,147 | $6,637,979 | 6 | Lucky Red | false | false |
| 11 | 8 | Gomorrah | $70,859 | -42.1% | 71 | -79 | $998 | $15,165,608 | 8 | 01 Distribution | false | false |
| 12 | 7 | Indiana Jones and the Kingdom of the Crystal Skull | $53,226 | -58.2% | 58 | -76 | $917 | $17,777,345 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Go Go Tales | $47,147 | -26.2% | 27 | -16 | $1,746 | $224,370 | 3 | Mediafilm | false | false |
| 14 | 13 | Impy's Island | $34,118 | -26.3% | 92 | -39 | $370 | $102,850 | 2 | Mediafilm | false | false |
| 15 | 14 | Once | $29,473 | -14.9% | 24 | -5 | $1,228 | $550,836 | 6 | Sacher Distribuzione | false | false |
| 16 | - | Man About Town | $25,412 | - | 51 | - | $498 | $25,412 | 1 | Warner Bros. | true | false |
| 17 | 22 | Don't Waste Your Time, Johnny! | $23,799 | +150.8% | 6 | +4 | $3,966 | $593,486 | 32 | Medusa Distribuzione | false | false |
| 18 | 18 | The Year My Parents Went on Vacation | $20,277 | -11.6% | 16 | -4 | $1,267 | $285,104 | 5 | Lucky Red | false | false |
| 19 | 16 | 12 | $20,199 | -21.8% | 16 | +1 | $1,262 | $62,537 | 2 | 01 Distribution | false | false |
| 20 | 19 | The Rest of the Night 2008 Re-release | $18,864 | -14.9% | 23 | -4 | $820 | $222,054 | 4 | 01 Distribution | false | false |
| 21 | 17 | Things We Lost in the Fire | $14,069 | -43.3% | 21 | -19 | $669 | $382,067 | 4 | Teodora Film | false | false |
| 22 | - | Il peso dell'aria | $12,070 | - | 4 | - | $3,017 | $15,573 | 1 | - | true | false |
| 23 | 33 | Non pensarci | $10,938 | +114.8% | 6 | +3 | $1,823 | $2,202,575 | 14 | 01 Distribution | false | false |
| 24 | - | Perfect Creature | $8,701 | - | 10 | - | $870 | $8,701 | 1 | 20th Century Fox International | true | false |
| 25 | 23 | Ho ammazzato Berlusconi | $8,422 | -8.8% | 4 | - | $2,105 | $52,795 | 3 | Independent Films | false | false |
| 26 | 30 | The Darjeeling Limited | $8,299 | +56.6% | 8 | +4 | $1,037 | $1,075,753 | 10 | 20th Century Fox International | false | false |
| 27 | - | The Kite Runner | $7,108 | - | 5 | - | $1,421 | $12,765,905 | 15 | Filmauro | false | false |
| 28 | 26 | Tutta la vita davanti | $6,727 | -9.2% | 4 | -3 | $1,681 | $6,063,455 | 15 | Medusa Distribuzione | false | false |
| 29 | 27 | Woman's Hearts | $6,281 | -15.1% | 4 | -2 | $1,570 | $48,540 | 4 | N/A | false | false |
| 30 | 29 | In Bruges | $5,821 | -1.7% | 6 | -2 | $970 | $702,352 | 8 | Mikado Film | false | false |
| 31 | - | The Game Plan | $5,595 | - | 15 | - | $373 | $5,595 | 1 | Walt Disney Pictures | true | false |
| 32 | 12 | The Ruins | $5,012 | -89.3% | 14 | -36 | $358 | $79,180 | 2 | Universal Pictures International (UPI) | false | false |
| 33 | 21 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $4,839 | -50.7% | 7 | -1 | $691 | $42,171 | 3 | Walt Disney Pictures | false | false |
| 34 | - | Lower City 2008 Re-release | $4,680 | - | 5 | - | $936 | $4,680 | 1 | - | true | false |
| 35 | 25 | Savage Grace | $4,153 | -47.1% | 12 | -3 | $346 | $45,565 | 3 | BIM Distribuzione | false | false |
| 36 | 49 | The Other Boleyn Girl | $4,100 | +223.3% | 7 | +4 | $585 | $2,127,712 | 11 | Universal Pictures International (UPI) | false | false |
| 37 | 34 | Italian Dream | $3,978 | -12.4% | 6 | -1 | $663 | $12,489 | 2 | Lucky Red | false | false |
| 38 | 24 | The Night of the Sunflowers | $3,934 | -53.8% | 6 | -5 | $655 | $52,334 | 4 | Istituto Luce | false | false |
| 39 | 20 | Tuttifrutti | $3,923 | -79.1% | 2 | -19 | $1,961 | $116,776 | 8 | N/A | false | false |
| 40 | - | Quiet Chaos | $3,736 | - | 5 | - | $747 | $8,405,766 | 22 | 01 Distribution | false | false |
| 41 | - | Into the Wild | $3,726 | - | 4 | - | $931 | $7,972,426 | 24 | BIM Distribuzione | false | false |
| 42 | - | No Country for Old Men | $3,521 | - | 2 | - | $1,760 | $9,017,291 | 20 | Universal Pictures International (UPI) | false | false |
| 43 | - | Irina Palm | $3,059 | - | 5 | - | $611 | $2,597,453 | 31 | Teodora Film | false | false |
| 44 | 36 | Elite Squad | $3,029 | -29.9% | 5 | -3 | $605 | $216,603 | 5 | Mikado Film | false | false |
| 45 | 31 | The Wind Blows Round | $2,996 | -42.5% | 1 | -2 | $2,996 | $668,827 | 62 | Aranciafilm | false | false |
| 46 | - | The Right Distance | $2,858 | - | 3 | - | $952 | $1,491,000 | 38 | 01 Distribution | false | false |
| 47 | - | Dr. Plonk | $2,643 | - | 4 | - | $660 | $2,643 | 1 | Fandango | true | false |
| 48 | 28 | Wild Blood | $2,568 | -62.3% | 9 | -9 | $285 | $919,271 | 7 | 01 Distribution | false | false |
| 49 | - | Be Kind Rewind | $2,564 | - | 3 | - | $854 | $217,279 | 7 | BIM Distribuzione | false | false |
| 50 | - | Gravehopping | $2,357 | - | 1 | - | $2,357 | $2,357 | 1 | N/A | true | false |
