| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hancock | $82,418 | - | 8 | - | $10,302 | $83,151 | 1 | ACME | true | false |
| 2 | 1 | Wanted | $31,264 | -59.2% | 6 | - | $5,210 | $168,773 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Kung Fu Panda | $17,820 | -30.6% | 9 | - | $1,980 | $429,676 | 5 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | The Chronicles of Narnia: Prince Caspian | $9,668 | -52.9% | 6 | - | $1,611 | $116,867 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 5 | Sex and the City | $8,051 | -41.7% | 6 | - | $1,341 | $260,744 | 5 | Garsu Pasaulio Irasai | false | false |
| 6 | - | Pathology | $7,740 | - | 4 | - | $1,935 | $11,553 | 1 | ACME | true | false |
| 7 | 4 | Forgetting Sarah Marshall | $7,495 | -50.9% | 6 | - | $1,249 | $93,170 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | - | Nim's Island | $4,900 | - | 5 | - | $980 | $6,965 | 1 | ACME | true | false |
| 9 | 8 | The Orphanage | $2,501 | -49.1% | 3 | - | $833 | $30,854 | 3 | ACME | false | false |
| 10 | 6 | The Happening | $2,281 | -72.8% | 5 | - | $456 | $132,055 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 11 | What Happens in Vegas | $1,958 | -21.1% | 4 | - | $489 | $279,831 | 8 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | Lost in Beijing | $911 | -61.4% | 1 | - | $911 | $5,519 | 2 | N/A | false | false |
| 13 | 7 | Never Back Down | $612 | -88.8% | 4 | - | $153 | $12,829 | 2 | ACME | false | false |
| 14 | 14 | The Ruins | $488 | +18.4% | 1 | - | $488 | $77,047 | 13 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | The Incredible Hulk | $344 | -87.3% | 2 | - | $172 | $50,376 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 9 | Indiana Jones and the Kingdom of the Crystal Skull | $229 | -94% | 2 | - | $114 | $266,108 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | 13 | Speed Racer | $156 | -62.2% | 6 | - | $26 | $45,663 | 8 | Garsu Pasaulio Irasai | false | false |
| 18 | 17 | Iron Man | $70 | -68.5% | 1 | - | $70 | $158,882 | 10 | Universal Pictures International (UPI) | false | false |
| 19 | - | Loss | $66 | - | 1 | - | $66 | $272,047 | 26 | Universal Pictures International (UPI) | false | false |
| 20 | - | Fool's Gold | $54 | - | 2 | - | $27 | $95,143 | 9 | Garsu Pasaulio Irasai | false | false |
