| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Quantum of Solace | $259,998 | - | 55 | - | $4,727 | $259,998 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | El Regalo | $41,490 | -32.3% | 35 | +1 | $1,185 | $403,225 | 6 | - | false | false |
| 3 | 1 | Mamma Mia! | $33,308 | -47.7% | 37 | +1 | $900 | $267,910 | 4 | United International Pictures | false | false |
| 4 | 4 | Mirrors | $31,173 | -42.1% | 25 | -1 | $1,246 | $412,344 | 6 | 20th Century Fox International | false | false |
| 5 | 3 | The Nightmare Before Christmas 2009 3D Release | $30,563 | -45.9% | 3 | - | $10,187 | $133,235 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | REC | $23,770 | -37.3% | 15 | -2 | $1,584 | $74,473 | 2 | CDI Films | false | false |
| 7 | 8 | Space Chimps | $17,365 | -34.8% | 20 | - | $868 | $198,008 | 6 | Bazuca Films | false | false |
| 8 | 6 | The Other Boleyn Girl | $15,526 | -51.1% | 14 | +2 | $1,109 | $55,833 | 2 | Bazuca Films | false | false |
| 9 | 9 | Nim's Island | $14,052 | -46.7% | 12 | - | $1,171 | $44,217 | 2 | United International Pictures | false | false |
| 10 | 11 | Journey to the Center of the Earth | $13,075 | -46.9% | 24 | -5 | $544 | $1,437,124 | 14 | Warner Bros. | false | false |
| 11 | 7 | Blindness | $10,641 | -60.8% | 23 | -3 | $462 | $73,223 | 3 | 20th Century Fox International | false | false |
| 12 | 10 | Tropic Thunder | $9,230 | -64.1% | 15 | -5 | $615 | $178,263 | 5 | United International Pictures | false | false |
| 13 | 12 | 88 Minutes | $8,030 | -59.5% | 15 | -2 | $535 | $53,873 | 3 | Bazuca Films | false | false |
| 14 | 14 | Before the Devil Knows You're Dead | $6,386 | -48.8% | 9 | +1 | $709 | $82,756 | 5 | Bazuca Films | false | false |
| 15 | 13 | Nights in Rodanthe | $6,309 | -49.7% | 15 | +2 | $420 | $1,322,989 | 6 | Warner Bros. | false | false |
| 16 | - | My Blueberry Nights | $5,961 | - | 7 | - | $851 | $5,961 | 1 | Bazuca Films | true | false |
| 17 | 15 | Awake | $5,778 | -44.7% | 11 | -1 | $525 | $57,777 | 4 | Bazuca Films | false | false |
| 18 | 22 | Babylon A.D. | $2,220 | -19.8% | 6 | -2 | $370 | $99,584 | 8 | 20th Century Fox International | false | false |
| 19 | 16 | The Diving Bell and the Butterfly | $2,008 | -72% | 5 | - | $401 | $10,756 | 2 | Transeuropa | false | false |
| 20 | 17 | The Mist | $1,660 | -62.5% | 6 | -6 | $276 | $198,873 | 9 | Bazuca Films | false | false |
| 21 | 18 | Death at a Funeral | $1,013 | -76.6% | 1 | -1 | $1,013 | $160,002 | 12 | Impacto Cine | false | false |
| 22 | 20 | You Don't Mess with the Zohan | $722 | -80% | 3 | -6 | $240 | $527,900 | 9 | Sony Pictures Releasing | false | false |
